Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

Zaid, Nurul Amirah Mohd; Sekar, Mahendran; Bonam, Srinivasa Reddy; Gan, Siew Hua; Lum, Pei Teng; Begum, M. Yasmin; Rani, Nur Najihah Izzati Mat; Vaijanathappa, Jaishree; Wu, Yuan Seng; Subramaniyan, Vetriselvan; Fuloria, Neeraj Kumar; Fuloria, Shivkanya

doi:10.2147/dddt.s326332

Cited by 63 publications

(41 citation statements)

References 260 publications

(440 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may also be related to the fact that, in contrast to the Gujjar and Bakarwal populations, which frequently intermarry, the Kashmiri community is strongly endogamous due to its geographical location. Similar results were reported by [ 8 ] from the North-West Frontier Province, Pakistan, [ 33 , 50 , 51 ] and from the Western Himalayas of Jammu and Kashmir.…”

Section: Resultssupporting

confidence: 89%

Keeping Healthy in Your Skin—Plants and Fungi Used by Indigenous Himalayan Communities to Treat Dermatological Ailments

Haq

Khoja

Lone³

et al. 2023

Plants

View full text Add to dashboard Cite

Dermatological ailments are a major health problem, especially when related to human immune deficiency syndrome and acquired immune deficiency. The goal of this study was to identify the medicinal plants used by the indigenous peoples of the Northwestern Himalayas to treat dermatological diseases. Several field trips were conducted in the spring and summer seasons of 2020–2021 to collect the plants of dermatological value and information about their use through open-ended semi-structured interviews (n = 53) and group discussions (n = 33). The current investigation found 64 ethnomedicinal plants belonging to 34 families commonly used to treat a variety of dermatological ailments. The main growth form was herbs (80%), followed by trees (8%) and ferns (6%). It was found that leaves (51%) were the most commonly used plant part, followed by roots and the whole plant. Wound healing was the most dominant application, with 18 plant species used, followed by skin burns cured by 11 plant species and skin boils by eight plant species. Out of the total (18%) of medicinal plants with cosmetic uses, i.e., roots of Jurinea dolomiaea, Rheum webbianum, and Rheum spiciforme were crushed into powder and mixed with turmeric, and the paste is applied topically for glowing skin. Among the various preparation methods, paste (38%) was the most common way of preparation, followed by poultice (29%) and infusion (9%). Between ethnic groups, the maximum homogeneity was between Gujjar and Bakarwal ethnic groups (23 species, 36%), followed by Gujjars and Kashmiri (14 species, 22%). Bakarwals and Gujjar people live in the same geographical location, and they graze their animals in pastures, practice extensive transhumance pastoralism, and pass through different ecological landscapes, thus having sufficient experiences with certain plants and retaining more knowledge. The species identified with the highest utilization based on the number of citations and use value included Ficus carica, Cichorium intybus, Euphorbia wallichii, Pinus wallichiana, Plantago major, Jurinea dolomiaea, and Artemisia absinthium. The findings of this study demonstrate that people who reside in the Northwestern Himalayas region still rely on medicinal plants.

show abstract

Section: Resultssupporting

confidence: 89%

Keeping Healthy in Your Skin—Plants and Fungi Used by Indigenous Himalayan Communities to Treat Dermatological Ailments

Haq

Khoja

Lone³

et al. 2023

Plants

View full text Add to dashboard Cite

show abstract

“…Phyto-compounds, extracted from plants, are generally characterized by reduced side effects in long-term treatments and low production costs. In addition, complementary approaches based on natural compounds are gaining increasing attention due to superior patient compliance compared to traditional synthetic drugs [27][28][29]. Our data have shown that CINNA administration is able to reduce LPS-induced IL-1β and IL-6 release in human PBMCs, and consistently also in THP-1 macrophages.…”

Section: Discussionmentioning

confidence: 70%

SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia.

Vezzani,

Perrone,

Carinci

et al. 2023

Preprint

View full text Add to dashboard Cite

Introduction: The recent pandemic outbursts, due to SARS-CoV-2, has highlighted once more the central role of the inflammatory process in the propagation of viral infection. In fact, the main consequence of COVID-19 is the induction of a diffuse pro-inflammatory state, also defined as cytokine storm, that affects different organs, but mostly the lungs. Therefore, despite the progress in the vaccination campaign, the high mutability of this virus also requires effective pharmaceutical approaches aimed to reduce the inflammatory spread. Methods The effect of SARS-CoV-2 infection on IL-1β and IL-6 levels was assessed by performing ELISA on patients' serum and stimulated-PBMCs. The therapeutic potential of cinnamaldehyde on COVID-19 was evaluated in vitro, testing the effects on THP-1 macrophages' inflammatory state, and on the viral replication in Calu-3 and Vero6 cells. Moreover, we assessed the effect of cinnamaldehyde also in vivo generating a lung-inflammatory model by intranasal administration of LPS. Results In this study we highlight that COVID-19 patients have higher IL-1β and IL-6 plasma levels compared to non-COVID-19 pneumonia patients, showing that human mononuclear cells (PBMCs) isolated from SARS-CoV-2 infected patients are more prone to release pro-inflammatory cytokines upon stimuli. Furthermore, we demonstrated how cinnamaldehyde, a natural compound easily tolerated by the majority of human beings, significantly reduces SARS-CoV-2-related inflammation by inhibiting IL-1β release by macrophages, and viral replication in epithelial cells. In addition, we confirmed the ability of aerosol-administered cinnamaldehyde to in vivo reduce IL-1β release in a lung-inflammatory model. Conclusion The obtained results suggest the possible use of cinnamaldehyde suitable as a co-adjuvant preventive treatment for COVID-19 disease together with vaccination, but also as a promising dietary supplement to reduce, more broadly, viral induced inflammation.

show abstract

“…Fruits are rich in antioxidants and are considered to be more antioxidant than vitamin C [78] . Natural products, because of their antioxidant nature can be beneficial in skin disorders through their antimicrobial, wound healing, and antiinflammatory properties [79] . The role of amla phytochemicals in alleviating eye problems, skin disorders, and allergy is yet to be determined; however, antioxidants/antiinflammatory phytochemicals in amla can be beneficial in eye disorders like conjunctivitis and inhibit progress of diabetic retinopathy [80] .…”

Section: Resultsmentioning

confidence: 99%

Medicinal plants and their uses by a folk medicinal practitioner of Matlab Upazila in Chandpur district, Bangladesh

Ahmed¹,

Jahan²,

Rahmatullah³

2023

J. Med. Plants Stud.

View full text Add to dashboard Cite

Background: Bangladesh is a small developing country with the majority population still residing in villages; most villages lack many modern amenities like proper drinking water facilities, sanitation, and conventional (allopathic) doctors and hospitals. On the other hand, although it is getting lost with possibly every passing day, villagers have a long history of traditional medicinal practitioners, who are also known as folk medicinal practitioners or Kavirajes (in Bengali). Kavirajes for the most part use medicinal plants, which are locally available for treatment and thus saves the villagers from costly conventional treatment, the medicines of which are neither readily available nor affordable. Once common, Kavirajes are fast disappearing along with loss of their folk medicinal knowledge. This loss is irreparable because plants and their phytochemicals still form the basis for discovery of modern drugs. For more than a decade, we had been conducting ethnomedicinal surveys among folk and tribal medicinal practitioners of Bangladesh. Methods and Findings: Interviews were conducted of the only folk medicinal practitioner (FMP) in Matlab Upazila. Prior permission was obtained from the FMP. Interviews were conducted with the help of a semi-structured questionnaire, extensive discussions, and field trips to areas frequented by the FMP to collect medicinal plants. Information was noted carefully. Plants were pictured, and plant samples identified by a trained botanist following collection, drying and mounting onto herbarium sheets. We could obtain information on only ten formulations, which were used for treatment of respiratory disorders, gastrointestinal tract disorders, pain, dengue, diabetes, acne, fever, eye problems, jaundice, gonorrhea, sexual problems, and debility. Conclusions: The richness of folk medicinal practice can be glimpsed from the diversity of illnesses treated with just twelve medicinal plant species. Some of these plants urgently need scientific attention before plants and FMPs disappear altogether. The phytochemicals present in the plants can be sources of potential drugs, lead compounds, or scaffolds for better drugs.

show abstract

Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

Cited by 63 publications

References 260 publications

Keeping Healthy in Your Skin—Plants and Fungi Used by Indigenous Himalayan Communities to Treat Dermatological Ailments

Keeping Healthy in Your Skin—Plants and Fungi Used by Indigenous Himalayan Communities to Treat Dermatological Ailments

SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia.

Medicinal plants and their uses by a folk medicinal practitioner of Matlab Upazila in Chandpur district, Bangladesh

Contact Info

Product

Resources

About