Promising natural products for the treatment of cutaneous leishmaniasis: A review of in vitro and in vivo studies

Afonso, R.C.; Yien, Raíssa Mara Kao; Siqueira, Luciana de Oliveira de Betzler; Simas, Naomi Kato; Matos, Ana Paula dos Santos; Ricci, Esther Lopes

doi:10.1016/j.exppara.2023.108554

Cited by 3 publications

(2 citation statements)

References 76 publications

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“…These include, for example, marbofloxacin, a third-generation fluoroquinolone, and DDD853651/GSK3186899, a pyrazolopyrimidine ( Sheikh et al, 2024 ). Natural compounds such as chalcones, alkaloids, quinolines and pyridines have also been shown to be effective against these parasites ( Pal et al, 2023 ), with ursolic acid, coumarin, gallic acid and apigenin, among others, being particularly active ( Afonso et al, 2023 ). In addition, other strategies such as the combination of drugs with immunotherapy have shown encouraging results.…”

Section: Introductionmentioning

confidence: 99%

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Bethencourt-Estrella,

Delgado-Hernández,

López-Arencibia

et al. 2024

International Journal for Parasitology: Drugs and Drug Resistan

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Section: Introductionmentioning

confidence: 99%

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Bethencourt-Estrella,

Delgado-Hernández,

López-Arencibia

et al. 2024

International Journal for Parasitology: Drugs and Drug Resistan

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“…The need for innovative, safer therapeutic approaches is therefore urgent. Research has been moving toward botanical therapies in recent years, intending to develop less toxic and more effective treatments for leishmaniasis (Afonso et al., 2023 ; Silveira et al., 2020 ). B. serrata essential oil, derived from Boswellia trees, is one potential candidate.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of antileishmanial activity of Boswellia serrata essential oil nanoliposome

Babaei,

Youssefi,

Nasrabadi

2024

Veterinary Medicine & Sci

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BackgroundLeishmaniasis poses a significant health risk.ObjectivesThis study aimed to evaluate the effects of Boswellia serrata (B. serrata) essential oil nanoliposomes on Leishmania tropica (L. tropica) in vitro.MethodsA mixture of B. serrata essential oil, phosphatidylcholine and Tween 80 were used to prepare B. serrata essential oil nanoliposomes, followed by drying, hydration and size characterisation. The promastigotes of L. tropica were cultured in Roswell Park Memorial Institute medium (RPMI‐1640) containing streptomycin, penicillin and fetal bovine serum. Different concentrations of B. serrata essential and nanoliposomes were tested for their antileishmanial properties by 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium Bromide tests (MTT).ResultsResults of Dynamic Light Scattering (DLS) for B. serrata nanoliposomes indicate that they are successful at producing nanoliposomes with dimensions of 74.8 nm. At 1 μg/mL dose, B. serrata essence caused 17 ± 1.73% mortality, while B. serrata nanoliposomes induced 26 ± 1.15% mortality. B. serrata essence achieved a mortality of 55 ± 2.88% at 10 μg/mL, whereas B. serrata nanoliposomes demonstrated a mortality of 63.66±0.88% at 10 μg/mL. Furthermore, there was a significant difference between similar concentrations of B. serrata and B. serrata nanoliposomes. The LC50 of B. serrata essential oil is 7.26 μg/mL in the 95% confidence interval (12.13–5.25). The LC90 value of B. serrata essential oil is 129.37 μg/mL in the 95% confidence interval (50.07–852.58). The LC50 value of B. serrata nanoliposome is 4.20 μg/mL in the 95% confidence interval (6.13–3.10). LC90 value for B. serrata nanoliposome is calculated as 91.89 μg/mL in the 95% confidence interval (37.09–583.29).ConclusionsIn vitro experiments have shown that B. serrata oil and the nanoliposome suppress the proliferation of L. tropica promastigotes, which suggests it may be a promising option for treating leishmaniasis.

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New synthetic molecules incorporated into polymeric micelles used for treatment against visceral leishmaniasis

Freitas,

Pereira,

Lage

et al. 2024

Cytokine

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Promising natural products for the treatment of cutaneous leishmaniasis: A review of in vitro and in vivo studies

Cited by 3 publications

References 76 publications

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

In vitro evaluation of antileishmanial activity of Boswellia serrata essential oil nanoliposome

New synthetic molecules incorporated into polymeric micelles used for treatment against visceral leishmaniasis

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