Promising gene delivery system based on polyethylenimine-modified silica nanoparticles

Babaei, Maryam; Abnous, Khalil; Rahimizadeh, Mohammad; Ramezani, Mohammad

doi:10.1038/cgt.2016.73

Cited by 38 publications

(18 citation statements)

References 39 publications

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“…In the last decade, different cationic polymers, such as polyethylenimine (PEI) [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ], poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) [ 74 , 75 ], chitosan derivatives [ 76 ], poly l -arginine [ 77 ] or poly l -lysine (PLL) [ 78 ], have been reported as coatings for silica nanoparticles in gene delivery systems, either through simple electrostatic interactions with the surface silanol groups, through covalent silane coupling with trialkoxysilanes, or by amidation reactions of amine-containing polymers with carboxylated NPs [ 20 ]. Table 3 summarizes a variety of different polymer-modified silica-based gene delivery formulations recently reported in literature.…”

Section: Hybrid Silica Nanoparticlesmentioning

confidence: 99%

“…On the other hand, reducing the molecular weight efficiently reduces the cytotoxicity but can also significantly affect the transfection efficiency [ 20 ]. Several studies have reported MSNs coated with 10 kDa PEI as a suitable carrier for gene delivery, presenting better overall results than the same nanoparticles coated with 25 kDa PEI, 1.8 kDa PEI or the polymers alone [ 21 , 65 , 67 , 68 ].…”

Section: Hybrid Silica Nanoparticlesmentioning

confidence: 99%

“…However, as described in Table 4 , silica-based vectors coated with smaller molecular weight PEI [ 23 ] or with different polymers [ 82 ] were able to achieve similar results in transfection, while being much safer. Generally, the toxicity of polycations is greatly decreased when they are surface-adsorbed to silica nanoparticles or complexed with DNA, when compared to the toxicity of polymers in solution, since the surface immobilization and complexation reduce the polymer chain flexibility and charge density [ 68 , 74 ]. Additionally, simply aminated silica structures, presented better overall results than PEI or polymer-based commercial transfection agents [ 31 , 40 ].…”

Section: Silica-based Systems As An Alternative To Other Vectorsmentioning

confidence: 99%

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Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

2020

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Advances in gene therapy have been foreshadowing its potential for the treatment of a vast range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and successful outcome are highly dependent on the development of the ideal gene delivery system. On that matter, silica-based vectors have diverted some attention from viral and other types of non-viral vectors due to their increased safety, easily modifiable structure and surface, high stability, and cost-effectiveness. The versatility of silane chemistry and the combination of silica with other materials, such as polymers, lipids, or inorganic particles, has resulted in the development of carriers with great loading capacities, ability to effectively protect and bind genetic material, targeted delivery, and stimuli-responsive release of cargos. Promising results have been obtained both in vitro and in vivo using these nanosystems as multifunctional platforms in different potential therapeutic areas, such as cancer or brain therapies, sometimes combined with imaging functions. Herein, the current advances in silica-based systems designed for gene therapy are reviewed, including their main properties, fabrication methods, surface modifications, and potential therapeutic applications.

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Section: Hybrid Silica Nanoparticlesmentioning

confidence: 99%

Section: Hybrid Silica Nanoparticlesmentioning

confidence: 99%

Section: Silica-based Systems As An Alternative To Other Vectorsmentioning

confidence: 99%

See 1 more Smart Citation

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

2020

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“…Polyethylenimine (PEI) is versatile with material properties and behavior that varies greatly with molecular weight and the degree of branching [54]. High molecular weight (MW) PEI, which is generally branched in structure, results in higher transfection efficiency along with higher cytotoxicity.…”

Section: Polymer Nanoparticlesmentioning

confidence: 99%

Engineered Nanodelivery Systems to Improve DNA Vaccine Technologies

et al. 2020

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DNA vaccines offer a flexible and versatile platform to treat innumerable diseases due to the ease of manipulating vaccine targets simply by altering the gene sequences encoded in the plasmid DNA delivered. The DNA vaccines elicit potent humoral and cell-mediated responses and provide a promising method for treating rapidly mutating and evasive diseases such as cancer and human immunodeficiency viruses. Although this vaccine technology has been available for decades, there is no DNA vaccine that has been used in bed-side application to date. The main challenge that hinders the progress of DNA vaccines and limits their clinical application is the delivery hurdles to targeted immune cells, which obstructs the stimulation of robust antigen-specific immune responses in humans. In this updated review, we discuss various nanodelivery systems that improve DNA vaccine technologies to enhance the immunological response against target diseases. We also provide possible perspectives on how we can bring this exciting vaccine technology to bedside applications.

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“…2,10,26 Several types of nanocarrier have emerged for the drug delivery of chemotherapeutic agents, including magnetic and metallic NPs, such as iron oxide or gold NPs, silver NPs, nanodiamonds, carbon-based structures (graphene sheets and carbon nanotubes), polymeric NPs, dendrimers, quantum dots, hydrogel-based delivery systems, silica-based NPs, lipid-based NPs (liposomes), solid-lipid NPs, nanostructured lipid carriers (NLCs), viral NPs, and hybrid NPs. [27][28][29][30][31] Passive targeting of almost all nanocarriers occurs with poor selectivity and insufficient tumor cell uptake. A more advanced approach of targeting for oncology applications is the modification of the surface of NPs with specific tumor-homing ligands.…”

Section: • •mentioning

confidence: 99%

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Kebebe¹,

Liu²,

Wu³

et al. 2018

IJN

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Cancer has become one of the leading causes of mortality globally. The major challenges of conventional cancer therapy are the failure of most chemotherapeutic agents to accumulate selectively in tumor cells and their severe systemic side effects. In the past three decades, a number of drug delivery approaches have been discovered to overwhelm the obstacles. Among these, nanocarriers have gained much attention for their excellent and efficient drug delivery systems to improve specific tissue/organ/cell targeting. In order to enhance targeting efficiency further and reduce limitations of nanocarriers, nanoparticle surfaces are functionalized with different ligands. Several kinds of ligand-modified nanomedicines have been reported. Cell-penetrating peptides (CPPs) are promising ligands, attracting the attention of researchers due to their efficiency to transport bioactive molecules intracellularly. However, their lack of specificity and in vivo degradation led to the development of newer types of CPP. Currently, activable CPP and tumor-targeting peptide (TTP)-modified nanocarriers have shown dramatically superior cellular specific uptake, cytotoxicity, and tumor growth inhibition. In this review, we discuss recent advances in tumor-targeting strategies using CPPs and their limitations in tumor delivery systems. Special emphasis is given to activable CPPs and TTPs. Finally, we address the application of CPPs and/or TTPs in the delivery of plant-derived chemotherapeutic agents.

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Promising gene delivery system based on polyethylenimine-modified silica nanoparticles

Cited by 38 publications

References 39 publications

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

Engineered Nanodelivery Systems to Improve DNA Vaccine Technologies

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

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