Promising applications of phyto-fabricated silver nanoparticles: Recent trends in biomedicine

Mohanta, Yugal Kishore; Mishra, Awdhesh Kumar; Panda, Jibanjyoti; Chakrabartty, Ishani; Sarma, Bhaskar; Panda, Sujogya Kumar; Chopra, Hitesh; Zengin, Gokhan; Moloney, Mark G.; Sharifi-Rad, Majid

doi:10.1016/j.bbrc.2023.149126

Cited by 6 publications

(5 citation statements)

References 255 publications

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“…Many experiments are focused on the combination of existing biomaterials with metal nanoparticles. Indeed, the antimicrobial potential of metal nanoparticles has been studied in detail by numerous researchers (e.g., [ 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 ]). Based on recent evidence, metal nanoparticles may also have an important role to play in the diagnosis and even treatment of cancer [ 270 , 271 ]; this can be important in cases of bone degeneration and even fracturing due to cancer [ 272 , 273 ].…”

Section: Discussionmentioning

confidence: 99%

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Periferakis,

Troumpata

et al. 2024

Biomimetics

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The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others. The materials discussed in the context of this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium phosphate (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), and zirconia. While the recent research results are promising, further development is required to address the increasing antibiotic resistance exhibited by several common pathogens, the potential for fungal infections, and the potential toxicity of some metal nanoparticles. Other solutions, like the incorporation of phytochemicals, should also be explored. Incorporating artificial intelligence (AI) in the development of certain orthopedic implants and the potential use of AI against bacterial infections might represent viable solutions to these problems. Finally, there are some legal considerations associated with the use of biomaterials and the widespread use of 3D printing, which must be taken into account.

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Section: Discussionmentioning

confidence: 99%

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Periferakis,

Troumpata

et al. 2024

Biomimetics

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“…Recent reports demonstrated that leaf extracts are the best option for the biosynthesis of silver nanoparticles (AgNPs) due to the presence of phyto-compounds such as polyphenols, flavonoids, terpenoids, aliphatic alcohols, and aldehydes, which act both as bioreducing and capping agents in AgNPs synthesis. This process, called AgNPs phyto-synthesis, is based on Green Chemistry principles; therefore, it is a nontoxic, low-cost, and harmless process that uses natural resources, avoiding the use of hazardous ingredients [ 2 , 3 ]. Phyto-fabricated AgNPs (phyto-AgNPs) possess interesting bioactivities (e.g., antioxidant, antimicrobial, and antiproliferative qualities, among others) that make them suitable for biomedical applications [ 2 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…This process, called AgNPs phyto-synthesis, is based on Green Chemistry principles; therefore, it is a nontoxic, low-cost, and harmless process that uses natural resources, avoiding the use of hazardous ingredients [ 2 , 3 ]. Phyto-fabricated AgNPs (phyto-AgNPs) possess interesting bioactivities (e.g., antioxidant, antimicrobial, and antiproliferative qualities, among others) that make them suitable for biomedical applications [ 2 , 4 , 5 ]. Composite materials containing phyto-AgNPs have been applied as coatings for medical devices, medical fabrics, or scaffolds, diabetic socks, wound dressings, and tissue engineering and regeneration [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Phyto-fabricated AgNPs (phyto-AgNPs) possess interesting bioactivities (e.g., antioxidant, antimicrobial, and antiproliferative qualities, among others) that make them suitable for biomedical applications [ 2 , 4 , 5 ]. Composite materials containing phyto-AgNPs have been applied as coatings for medical devices, medical fabrics, or scaffolds, diabetic socks, wound dressings, and tissue engineering and regeneration [ 2 ]. Biocomposites based on biocompatible polymers and phyto-AgNPs have antibacterial properties and may help protect a scaffold against infection [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Biocomposite Materials Derived from Andropogon halepensis: Eco-Design and Biophysical Evaluation

Barbinta-Patrascu,

Nichita,

Bita

et al. 2024

Materials

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This research work presents a “green” strategy of weed valorization for developing silver nanoparticles (AgNPs) with promising interesting applications. Two types of AgNPs were phyto-synthesized using an aqueous leaf extract of the weed Andropogon halepensis L. Phyto-manufacturing of AgNPs was achieved by two bio-reactions, in which the volume ratio of (phyto-extract)/(silver salt solution) was varied. The size and physical stability of Andropogon—AgNPs were evaluated by means of DLS and zeta potential measurements, respectively. The phyto-developed nanoparticles presented good free radicals-scavenging properties (investigated via a chemiluminescence technique) and also urease inhibitory activity (evaluated using the conductometric method). Andropogon—AgNPs could be promising candidates for various bio-applications, such as acting as an antioxidant coating for the development of multifunctional materials. Thus, the Andropogon-derived samples were used to treat spider silk from the spider Pholcus phalangioides, and then, the obtained “green” materials were characterized by spectral (UV-Vis absorption, FTIR ATR, and EDX) and morphological (SEM) analyses. These results could be exploited to design novel bioactive materials with applications in the biomedical field.

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“…The antimicrobial attributes of the plants hold the potential for safeguarding wounds against infections. E. tirucalli has a history of traditional use in certain cultures for wound healing and addressing various health concerns [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Euphorbia tirucalli-Mediated Titanium Dioxide Nanoparticles Against Wound Pathogens

Natarajan Sankar,

Shanmugam,

Anandan

2024

Cureus

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Background Wound infections caused by pathogens present a considerable global health challenge, resulting in extended healing durations, elevated healthcare expenses, and potential fatalities. Conventional approaches to managing wound pathogens have limitations such as antibiotic resistance, toxicity and allergic reactions. Consequently, there is a rising interest in exploring alternative strategies for preventing and treating wound infections. Titanium dioxide nanoparticles (TiO 2 NPs) have gained attention for their potential in wound healing, attributed to their distinctive properties, including antimicrobial and anti-inflammatory capabilities. Methods TiO 2 NPs synthesized through Euphorbia tirucalli were examined for their antibacterial potential against wound pathogens, using the Kirby-Bauer agar-well diffusion method and time-kill curve assay. Furthermore, the cytotoxic effect of the synthesized nanoparticles was evaluated through a brine shrimp lethality assay. Results Green-synthesized TiO2NPs demonstrated potent antimicrobial activity against tested wound pathogens, displaying a zone of inhibition against Pseudomonas aeruginosa (11 mm) and Escherichia coli (10 mm) at the highest concentration of 100 μg/mL. In the time-kill curve assay, the prepared TiO 2 NPs showed significant bactericidal activity against Pseudomonas aeruginosa followed by Escherichia coli . In the brine shrimp lethality assay, at the lowest concentration of 5 μg/mL of the prepared nanoparticles, 100% of the nauplii remained alive after 48 hours. Conclusion The results indicate that TiO 2 NPs synthesized using Euphorbia tirucalli extract exhibit potent antimicrobial activity against the tested wound pathogens. Moreover, the prepared nanoparticles exhibit lower toxicity, suggesting their potential use as an alternative to commercially available synthetic drugs.

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Promising applications of phyto-fabricated silver nanoparticles: Recent trends in biomedicine

Cited by 6 publications

References 255 publications

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Biocomposite Materials Derived from Andropogon halepensis: Eco-Design and Biophysical Evaluation

Green Synthesis of Euphorbia tirucalli-Mediated Titanium Dioxide Nanoparticles Against Wound Pathogens

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