Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders

Hu, Hongzhi; Yang, Wenbo; Zeng, Qianwen; Chen, Wei; Zhu, Yanbin; Liu, Weijian; Wang, Shangyu; Wang, Baichuan; Shao, Zhimin; Zhang, Yingze

doi:10.1016/j.biopha.2020.110767

Cited by 48 publications

(48 citation statements)

References 150 publications

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“…In this study, after 12-weeks of treatment and 6-months of follow-up, an exercise protocol significantly increased lumbar and total hip BMD, enhanced bone formation, and suppressed bone resorption markers in males with osteopenia or osteoporosis. The current study's findings were in line with those of earlier clinical trials (Maddalozzo and Snow, 2000;Kukuljan et al, 2009;Almstedt et al, 2011;Bemben and Bemben, 2011;Kukuljan et al, 2011;Alayat et al, 2018) but not with those of other investigations (Huuskonen et al, 2001;Woo et al, 2007;Whiteford et al, 2010). The contrast between the current study findings and earlier studies could be explained by differences in study design, duration, age ranges, as well as exercise type and intensity (Huuskonen et al, 2001;Woo et al, 2007;Whiteford et al, 2010).…”

Section: Effect Of Exercise and Wbvsupporting

confidence: 89%

“…Several membrane receptors and pathways, including the PTH pathway, insulin, insulin-like growth factor (IGF-2), and calcitonin (Jiang et al, 2016), have been found to be affected by PEMFs in terms of ligand binding and distribution as well as activity. As a result, transmembrane signaling is modulated (Hu et al, 2020). PEMFs have a considerable antiinflammatory and analgesic effect on the joint environment (Varani et al, 2017).…”

Section: Effect Of Pemfmentioning

confidence: 99%

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Long-term effect of full-body pulsed electromagnetic field and exercise protocol in the treatment of men with osteopenia or osteoporosis: A randomized placebo-controlled trial

et al. 2021

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Background: Osteoporosis is the most prevalent metabolic disease affecting bones. Objective: To investigate the long-term effect of pulsed electromagnetic field (PEMF) combined with exercise protocol on bone mineral density (BMD) and bone markers in men with osteopenia or osteoporosis. Methods: Ninety-five males with osteopenia or osteoporosis (mean age, 51.26 ± 2.41 years; mean height, 176 ± 2.02 cm; mean weight, 83.08 ± 2.60 kg; mean body–mass index (BMI), 26.08 ± 1.09 kg/m2) participated in the study, and they were randomly assigned to one of three groups: Group 1 received a full-body PEMF and exercise protocol (PEMF +EX), Group 2 received a placebo full-body PEMF and exercise protocol (PPEMF +EX), and Group 3 received a full-body PEMF alone (PEMF). PEMF was applied for the whole body using a full-body mat three times per week for 12 weeks, with an exercise protocol that includes flexibility, aerobic exercise, strengthening, weight-bearing, and balance exercises followed by whole-body vibration (WBV) training. Outcome measures include BMD of total hip and lumbar spine and bone markers [serum osteocalcin (s-OC), Serum amino-terminal cross-linking telopeptide of type I collagen (s-NTX), Serum carboxy-terminal cross-linking telopeptide of type I collagen (s-CTX), Parathyroid hormones (PTH), Bone-specific Alkaline Phosphatase (BSAP), and 25-hydroxy vitamin D (Vit D)]. Results: The BMD of total hip and lumbar spine was significantly increased post-treatment in all groups, and more so in Group 1 and Group 2 than Group 3. There was a significant difference in bone markers in all groups, more so in Group 1 and Group 2 than in Group 3. Conclusion: PEMF combined with exercise protocol exerts a potent role for treating OP, is more effective than exercise and PEMF alone for increasing BMD and enhancing bone formation, and suppresses bone-resorption markers after 12-weeks of treatment with the impact lasting up to 6 months.

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Section: Effect Of Exercise and Wbvsupporting

confidence: 89%

Section: Effect Of Pemfmentioning

confidence: 99%

Long-term effect of full-body pulsed electromagnetic field and exercise protocol in the treatment of men with osteopenia or osteoporosis: A randomized placebo-controlled trial

et al. 2021

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“…In recent years, a number of studies suggested that an ET field was involved in numerous biologic processes which are of great importance for therapeutic interventions. Particularly, low-frequency fields are known to be a safe and effective therapy and are suggested as a promising adjuvant for treating various musculoskeletal disorders, including pain management [ 19 , 20 , 21 ]. In this current study, we used PLS therapy for treatment of musculoskeletal pain in older adults.…”

Section: Discussionmentioning

confidence: 99%

Effects of Personal Low-Frequency Stimulation Device on Myalgia: A Randomized Controlled Trial

Yoon

Cho

et al. 2022

IJERPH

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Electrotherapy is commonly used for myalgia alleviation. Low-frequency stimulation (LFS) is primarily used for controlling acute and chronic pain and is a non-invasive therapy that can be easily performed with electric stimulation applied on the skin. However, little evidence exists regarding the pain alleviation effects of personal low-frequency stimulation device for home use. Moreover, no studies have compared myalgia alleviation effects between personal low-frequency stimulation (PLS) and physical therapy (PT), which are most commonly used for patients with myalgia in hospitals and clinics. Therefore, we aimed to investigate the pain alleviation effects of PLS in patients with myalgia and compare these effects with those of conventional PT (transcutaneous electrical nerve stimulation + ultrasound). In total, 39 patients with myalgia in the neck, shoulder, back, and waist areas were randomly assigned to the personal low-frequency stimulation group (PLSG: n = 20) and physical therapy group (PTG: n = 19). Both groups were treated for 3 weeks (20 min per session and 5 sessions per week). Patients were assessed for pain intensity by surface electromyography (sEMG), visual analogue scale (VAS) and a short-form McGill pain questionnaire (SF-MPQ) before and after the intervention period. Our results showed that PLSG showed a tendency of muscle relaxation with a significant decrease in sEMG in the neck (p = 0.0425), shoulder (p = 0.0425), and back (p = 0.0046) areas compared to the control group. However, there was no significant difference in waist area. Additionally, VAS scores significantly decreased between pre- and post-treatment in both PTG (p = 0.0098), and PLSG (p = 0.0304) groups, but there was no significance difference between the groups. With respect to SF-MPQ, the PLSG showed greater pain alleviation (5.23 ± 0.25) effects than the PTG (6.23 ± 0.25). Accordingly, our results suggest that PLS treatment using a home device might offer positive assistance in pain alleviation for patients with myalgia that is as equally effective as conventional PT treatment. However, further detailed studies are required considering larger samples to fully claim the effectiveness of this device.

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“…In conclusion, with suitable patient selection, well defined indications, and consistent treatment strategies, PEMF have the potential to play a significant role in the management of musculoskeletal disorders in the future. 18 Effect of HILT Comparing to baseline scores, the combined HILT and exercise effectively improve the lumbar and hip BMD. By stimulating cytochrome oxidase in the mitochondrial activity of osteoblast cells, 35 laser treatment can modify cellular metabolism by contributing in the production of an electrochemical potential and the production of oxygen molecules that are utilized to generate adenosine triphosphate.…”

Section: The Pemf Effectsmentioning

confidence: 98%

“…3 Pulsed electromagnetic field (PEMF) has a lot of potential to become a stand-alone or adjuvant treatment approach for musculoskeletal disorders such osteopenia and OP because of its noninvasiveness, safety, and efficacy. 18 Several studies have investigated at the underlying cellular and subcellular mechanisms of PEMF stimulation on a variety of musculoskeletal disorders, providing a molecular basis for expanding its therapeutic application. [19][20][21][22] The paucity of studies focusing on such a high-impact population in Saudi Arabia is making it difficult to establish effective intervention programs that address specific concerns for this group.…”

Section: Introductionmentioning

confidence: 99%

Effect of pulsed electromagnetic field versus pulsed high intensity laser in the treatment of men with osteopenia or osteoporosis: a randomized controlled trial

et al. 2022

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Background: Osteoporosis has been related to a negative impact on several aspects of patient health, including physical, mental, and emotional well-being. The objective of this study was to examine the effects of pulsed electromagnetic fields (PEMF) and pulsed Nd-YAG laser therapy (HILT) on men with osteopenia or osteoporosis. Methods: Ninety-five men with osteopenia or osteoporosis (mean age, 52 years; mean height, 176 cm; mean weight, 83 kg; mean body-mass index (BMI), 26.86 kg/m2) took part in the study, and they were randomly assigned to one of three groups: Group 1 received PEMF and exercise program (PEMF +EX), Group 2 received HILT and exercise program (HILT+EX), and Group 3 received exercise program only (EX). PEMF was applied three times per week for 12 weeks using a full-body mat, while HILT was applied to the lower back and hip regions with a total dose of energy of 3000 J delivered in two treatment stages. Flexibility, aerobic exercise, strength, weight-bearing, and balance exercises are included in exercise program, which is followed by whole-body vibration training. Bone mineral density (BMD) of the total hip and lumbar spine, bone markers, health-related quality of life (HRQoL), and fall risk are all outcome measures. Results: There were no significant differences in the parameters between the groups at the baseline (P > 0.05). Patients in all groups, however, showed significant improvements in all measured parameters following treatment (P< 0.05), with Group 1 and Group 2 showing much greater improvements than Group 3. Conclusion: After 12-weeks of treatment, PEMF combined with exercise is more effective than HILT combined with exercise or exercise alone in increasing BMD and promoting bone formation, suppressing bone-resorption markers, and improving quality of life and fall risk, with the effects lasting up to six months. This study was registered in the ClinicalTrial.gov PRS (NCT05029440, 26/08/2021).

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Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders

Cited by 48 publications

References 150 publications

Long-term effect of full-body pulsed electromagnetic field and exercise protocol in the treatment of men with osteopenia or osteoporosis: A randomized placebo-controlled trial

Long-term effect of full-body pulsed electromagnetic field and exercise protocol in the treatment of men with osteopenia or osteoporosis: A randomized placebo-controlled trial

Effects of Personal Low-Frequency Stimulation Device on Myalgia: A Randomized Controlled Trial

Effect of pulsed electromagnetic field versus pulsed high intensity laser in the treatment of men with osteopenia or osteoporosis: a randomized controlled trial

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