Promising Antiproliferative Compound From the Green Microalga Dunaliella tertiolecta Against Human Cancer Cells

Martínez, Kevin A.; Saide, Assunta; Crespo, Gloria; Martín, Jesús; Romano, Giovanna; Reyes, Fernando; Lauritano, Chiara; Ianora, Adrianna

doi:10.3389/fmars.2022.778108

Cited by 10 publications

(4 citation statements)

References 38 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microalgal pellets were extracted as in Martinez et al [ 51 ]. Briefly, wet pellets (80% water content) were extracted by soaking in methanol (proportion 1:5, w / v ) and 30 min of maceration.…”

Section: Methodsmentioning

confidence: 99%

The Microalga Skeletonema marinoi Induces Apoptosis and DNA Damage in K562 Cell Line by Modulating NADPH Oxidase

et al. 2022

Self Cite

View full text Add to dashboard Cite

Chronic myeloid leukemia (CML) is a myeloproliferative disease that activates multiple signaling pathways, causing cells to produce higher levels of reactive oxygen species (ROS). Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are a major generator of ROS in leukemia, and marine natural products have shown promising activities for the treatment of hematopoietic malignancies. In the present study, we investigated the effect of the marine microalga Skeletonema marinoi (S.M.), a ubiquitous diatom that forms massive blooms in the oceans, on the human leukemia cell line K562. The effects of S.M. extract on cell viability, production of ROS, nitric oxide (NO), and apoptosis were examined. In this preliminary work, S.M. was able to decrease cell viability (p < 0.05) and increase apoptosis levels (p < 0.05) in K562 cells after 48 h of treatment. In addition, the levels of NOX, NO, and malondialdehyde (MDA) were reduced in K562-treated cells (p < 0.05), whereas the levels of SOD, CAT, and GPx increased during treatment (p < 0.05). Finally, analyzing Bax and Bcl-2 expression, we found a significant increase in the proapoptotic protein Bax and a sustained decrease in the antiapoptotic protein Bcl-2 (p < 0.05) in the K562-treated cells.

show abstract

Section: Methodsmentioning

confidence: 99%

The Microalga Skeletonema marinoi Induces Apoptosis and DNA Damage in K562 Cell Line by Modulating NADPH Oxidase

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…A series of primary and secondary metabolites of marine organisms with potential applications for the prevention and treatment of different cancers have been reported to date [ 24 , 25 , 26 , 27 ]. Currently, there are 14 marine-derived drugs on the market, 9 of which are for cancer treatment.…”

Section: Why Marine Organisms and Which Are The Marine-derived Drugs ...mentioning

confidence: 99%

Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries

Montuori

Hyde

Crea

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

Prostate cancer is the most common cancer in men, with over 52,000 new cases diagnosed every year. Diagnostics and early treatment are potentially hindered by variations in screening protocols, still largely reliant on serum levels of acid phosphatase and prostate-specific antigen, with tumour diagnosis and grading relying on histopathological examination. Current treatment interventions vary in terms of efficacy, cost and severity of side effects, and relapse can be aggressive and resistant to the current standard of care. For these reasons, the scientific community is looking for new chemotherapeutic agents. This review reports compounds and extracts derived from marine organisms as a potential source of new drugs against prostate cancer. Whilst there are several marine-derived compounds against other cancers, such as multiple myeloma, leukemia, breast and lung cancer, already available in the market, the presently collated findings show how the marine environment can be considered to hold potential as a new drug source for prostate cancer, as well. This review presents information on compounds presently in clinical trials, as well as new compounds/extracts that may enter trials in the future. We summarise information regarding mechanisms of action and active concentrations.

show abstract

“…The samples treated with lysozyme performed slightly better than cellulase-treatment on MDA MB-435 tumor cells [ 29 ]. However, other methods are also used for cell breakage, such as the use of sonication [ 30 , 31 , 32 , 33 ].…”

Section: Marine Microorganismsmentioning

confidence: 99%

Marine Compounds for Melanoma Treatment and Prevention

Montuori

Capalbo

Lauritano

2022

IJMS

Self Cite

View full text Add to dashboard Cite

Melanoma is considered a multifactorial disease etiologically divided into melanomas related to sun exposure and those that are not, but also based on their mutational signatures, anatomic site, and epidemiology. The incidence of melanoma skin cancer has been increasing over the past decades with 132,000 cases occurring globally each year. Marine organisms have been shown to be an excellent source of natural compounds with possible bioactivities for human health applications. In this review, we report marine compounds from micro- and macro-organisms with activities in vitro and in vivo against melanoma, including the compound Marizomib, isolated from a marine bacterium, currently in phase III clinical trials for melanoma. When available, we also report active concentrations, cellular targets and mechanisms of action of the mentioned molecules. In addition, compounds used for UV protection and melanoma prevention from marine sources are discussed. This paper gives an overview of promising marine molecules which can be studied more deeply before clinical trials in the near future.

show abstract

Promising Antiproliferative Compound From the Green Microalga Dunaliella tertiolecta Against Human Cancer Cells

Cited by 10 publications

References 38 publications

The Microalga Skeletonema marinoi Induces Apoptosis and DNA Damage in K562 Cell Line by Modulating NADPH Oxidase

The Microalga Skeletonema marinoi Induces Apoptosis and DNA Damage in K562 Cell Line by Modulating NADPH Oxidase

Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries

Marine Compounds for Melanoma Treatment and Prevention

Contact Info

Product

Resources

About