Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of action
Annie-Peiyuan Luo,
Carlo Giannangelo,
Ghizal Siddiqui
et al.
Abstract:Over the last two decades, global malaria cases caused by Plasmodium falciparum have declined due to the implementation of effective treatments and the use of insecticides. However, the COVID-19 pandemic caused major disruption in the timely delivery of medical goods and diverted public health resources, impairing malaria control. The emergence of resistance to all existing frontline antimalarials underpins an urgent need for new antimalarials with novel mechanisms of action. Furthermore, the need to reduce ma… Show more
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