Promising antifungal activity of <i>Croton tricolor</i> stem essential oil against <i>Candida</i> yeasts

Miranda, Fabricio Mendes; Nascimento, Baraquízio Braga do; Aguiar, Rosane Moura; Pereira, Rafael; Teixeira, Adonias De Oliveira; Oliveira, Djalma Menezes de; Lima, Edeltrudes de Oliveira; Oigman, Silvia Siag; Rezende, Cláudia M.; Froldi, Guglielmina

doi:10.1080/10412905.2018.1539416

Cited by 7 publications

(1 citation statement)

References 19 publications

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“…However, a high variability could be appreciated in the main components of EOs extracted from stems of Croton spp. For example, Miranda et al in 2019 [ 41 ] stated that the constituents of the EO from Croton tricolor Klotzsch ex Baill. were epi -globulol (19.0%), α -bisabolol (16.5%), trans - α -bergamotol (14.4%), and β -caryophyllene (9.1%).…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition and In Vitro and In Silico Antileishmanial Evaluation of the Essential Oil from Croton linearis Jacq. Stems

et al. 2022

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Croton linearis Jacq. is an aromatic shrub that has been utilized in traditional medicine in the Bahamas, Jamaica, and Cuba. Recent studies have revealed the antiprotozoal potential of its leaves. The present work is aimed to identify the volatile constituents of essential oil from the stems of C. linearis (CLS-EO) and evaluate its in vitro antileishmanial activity. In addition, an in silico study of the molecular interactions was performed using molecular docking. A gas chromatographic–mass spectrometric analysis of CLS-EO identified 1,8-cineole (27.8%), α-pinene (11.1%), cis-sabinene (8.1%), p-cymene (5.7%), α-terpineol (4.4%), epi-γ-eudesmol (4.2%), linalool (3.9%), and terpinen-4-ol (2.6%) as major constituents. The evaluation of antileishmanial activity showed that CLS-EO has good activity on both parasite forms (IC50Promastigote = 21.4 ± 0.1 μg/mL; IC50Amastigote = 18.9 ± 0.3 μg/mL), with a CC50 of 49.0 ± 5.0 μg/mL on peritoneal macrophages from BALB/c mice (selectivity index = 2 and 3 using the promastigote and amastigote results). Molecular docking showed good binding of epi-γ-eudesmol with different target enzymes of Leishmania. This study is the first report of the chemical composition and anti-Leishmania evaluation of CLS-EO. These findings provide support for further studies of the antileishmanial effect of this product.

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Section: Discussionmentioning

confidence: 99%