Promising Antibiofilm Activity of Peptidomimetics

Abstract

Pathogenic biofilms are a global health care concern, as they can cause extensive antibiotic resistance, morbidity, mortality, and thereby substantial economic loss. Scientific efforts have been made over the past few decades, but so far there is no effective treatment targeting the bacteria in biofilms. Antimicrobial peptidomimetics have been proposed as promising potential anti-biofilm agents. Indeed, these structurally enhanced molecules can mimic the action of peptides but are not susceptible to proteolysis or immunogenicity, the characteristic limitations of natural peptides. Here, we provide insights into antibiofilm peptidomimetic strategies and molecular targets, and discuss the design of two major peptidomimetics classes: AApeptides (N-acylated-N-aminoethyl-substituted peptides) and peptoids (N-substituted glycine units). In particular, we present details of their structural diversity and discuss the possible improvements that can be implemented in order to develop antibiofilm drug alternatives.

Red pepper peptide coatings control Staphylococcus epidermidis adhesion and biofilm formation

“…43,[58][59][60] Recent literature reviews have shown that peptides and peptidomimetics from different sources have been investigated for their prominent antibiofilm activity. [61][62][63][64][65] There are no previous studies demonstrating a relationship between 2S sulfur-rich seed storage (2SS) proteins or peptides and antibiofilm activity. To the best of our knowledge, this is the first scientific report using Capsicum natural peptides as antibiofilm and antiadhesive agents, herein called red pepper coat.…”

Future prospects for Antimicrobial peptide development: peptidomimetics and antimicrobial combinations

“…Antimicrobial peptidomimetics are synthetic molecules derived from (or inspired by) natural AMPs that mimic or reproduce their physicochemical properties (cationic charge, hydrophobicity, amphiphilicity) and biological effects [8,9]. Nevertheless, peptidomimetics often exhibit a higher bioavailability and a longer half-life in vivo [5] and many of them are more resistant to protease degradation [10].…”

An Overview of Biological and Computational Methods for Designing Mechanism-Informed Anti-biofilm Agents

“…Design features that discriminate such anti-biofilm peptides are different from those mediating activity against planktonic cells (de la Fuente-Núñez et al, 2014;Haney et al, 2018a). Thus, antibiofilm peptides are an attractive class of molecules that can be further optimized through rational design (see below) or synthesis of peptidomimetics (Gomes Von Borowski et al, 2018).…”