Promising alternative clinical uses of prostaglandin F2α analogs: Beyond the eyelashes

Choi, Young Mee; Diehl, Joseph; Levins, Paul C.

doi:10.1016/j.jaad.2014.10.012

Cited by 36 publications

(20 citation statements)

References 37 publications

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“…An increase in pigmentation was observed with NBUVB combination with all three prostaglandin analogues. Choi et al (2015) study of human skinborne melanocytes showed that the presence of prostaglandin F receptors is a target analogue of PGF2α. The activation of prostaglandin F receptors was a powerful stimulant for dendritic cells of melanocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Due to side effects such as hypertrichosis and hyperpigmentation, this drug has been found to have therapeutic application in the treatment of alopecia areata, and hypopigmentation disorders (Alm, 2014;Choi, Diehl, & Levins, 2015;Dams, Wasyluk, Prost, & Kutner, 2013;Russo, Riva, Pizzolante, Noto, & Quaranta, 2008). Due to side effects such as hypertrichosis and hyperpigmentation, this drug has been found to have therapeutic application in the treatment of alopecia areata, and hypopigmentation disorders (Alm, 2014;Choi, Diehl, & Levins, 2015;Dams, Wasyluk, Prost, & Kutner, 2013;Russo, Riva, Pizzolante, Noto, & Quaranta, 2008).…”

Section: Latanoprost Reduces Intraocular Pressure In Patients With Openmentioning

confidence: 99%

“…angle glaucoma and hypertension. Due to side effects such as hypertrichosis and hyperpigmentation, this drug has been found to have therapeutic application in the treatment of alopecia areata, and hypopigmentation disorders (Alm, 2014;Choi, Diehl, & Levins, 2015;Dams, Wasyluk, Prost, & Kutner, 2013;Russo, Riva, Pizzolante, Noto, & Quaranta, 2008). So the aim of this present study was to evaluate the efficacy of topical latanoprost in the treatment of eyelid vitiligo.…”

Section: Latanoprost Reduces Intraocular Pressure In Patients With Openmentioning

confidence: 99%

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Efficacy of topical latanoprost in the treatment of eyelid vitiligo: A randomized, double‐blind clinical trial study

Dailami

Hosseini

Rokni

et al. 2019

Dermatologic Therapy

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Numerous studies have demonstrated that the pigmentation of iris and around the eyelid is a common side effect of latanoprost, a prostaglandin F2alpha analogue used in the treatment of glaucoma. Hence, the authors decided to study the effectiveness of topical latanoprost on vitiligo patches around the eyelid. In this randomized, double-blind, clinical trial study, 31 patients with vitiligo vulgaris and focal vitiligo involving the eyelids were evaluated. Patients were randomly divided into two groups. First group received topical latanoprost gel twice daily for 12 weeks, whereas the second group received placebo with the same protocol. To evaluate severity of the disease the VIDA rating system was used. Serial photos of the patches were taken to compare and evaluate the repigmentation percentage of the patches. The patients in both groups had almost similar VIDA score (p > .05). First group showed improved pigmentation, whereas participants in the second group did not show any improvement in the pigmentation. The group treated with latanoprost showed significant reduction in the symptoms of the disease, whereas those treated with placebo did not show any alteration (p > .05). No significant complications were observed in either groups. Latanoprost proved effective in treating vitiligo disease involving eyelids.

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Section: Discussionmentioning

confidence: 99%

Section: Latanoprost Reduces Intraocular Pressure In Patients With Openmentioning

confidence: 99%

Section: Latanoprost Reduces Intraocular Pressure In Patients With Openmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of topical latanoprost in the treatment of eyelid vitiligo: A randomized, double‐blind clinical trial study

Dailami

Hosseini

Rokni

et al. 2019

Dermatologic Therapy

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“…3 Histological confirmation is crucial before performing extensive surgery. Incisional and punch biopsy techniques have relatively high accuracy rates.…”

Section: Discussionmentioning

confidence: 99%

Irregularly luscious lashes: difficult to say but a sinister sign to miss

Hamroush

Cheung

2016

BMJ Case Reports

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SUMMARYWe present a case of an 84-year-old man with advanced glaucoma on multiple unilateral glaucoma medication. He had 2 years history of unilateral ocular irritation thought to be related to his medication. Patient was referred to an oculoplastic clinic and found to have segmental eyelash loss partially masked by hypertrichosis caused by glaucoma medications. His symptoms were initially thought to be related to drop-induced blepharitis. A clinical diagnosis of possible basal cell carcinoma (BCC) was made and the incisional biopsy showed infiltrative micronodular BCC. The patient underwent Mohs micrographic surgery and eyelid reconstruction with a Hughes flap and full thickness skin graft. Timely diagnosis of BCC requires a high index of suspicion, particularly when the signs are subtle. BACKGROUND

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“…Now it is known that prostaglandin D2 (PGD2) inhibits hair growth and prostaglandin E2 and F2α (PGE2/F2α) promote hair growth [33]. A randomized, double-blinded, placebo-controlled study of a PGF2α applied topically to men with AGA showed an increase in hair density and also extended the anagen phase [34,35]. PGD2 has been found to be elevated in the scalp of bald men, but no clinical studies are currently available to assess a PGD2 antagonist's effect on hair growth [33].…”

Section: Future Of Hair Transplantmentioning

confidence: 99%

An Update on Hair Restoration

Chan¹,

Ducic²

2015

IPJARS

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Hair restoration therapy has evolved significantly over the past few decades. Aesthetically pleasing and natural results are achieved with modern techniques utilizing follicular unit transfer. While the concept remains the same, various techniques have been developed for harvesting follicular units safely and reliably. Here, we review some of the techniques of obtaining follicular units for transplantation, medical treatment of androgenetic alopecia, and future directions in hair restoration therapy.

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Promising alternative clinical uses of prostaglandin F2α analogs: Beyond the eyelashes

Cited by 36 publications

References 37 publications

Efficacy of topical latanoprost in the treatment of eyelid vitiligo: A randomized, double‐blind clinical trial study

Efficacy of topical latanoprost in the treatment of eyelid vitiligo: A randomized, double‐blind clinical trial study

Irregularly luscious lashes: difficult to say but a sinister sign to miss

An Update on Hair Restoration

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