2002
DOI: 10.1097/01.asn.0000036868.73317.7a
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Prominent Renal Expression of a Murine Leukemia Retrovirus in Experimental Systemic Lupus Erythematosus

Abstract: Abstract.A role for retroviruses in human systemic lupus erythematosus (SLE) and in mouse lupus models such as the New Zealand Black and White mice (NZB/W) strain has been postulated. This study compared the gene profile of nephritic NZB/W kidney with nondiseased NZW controls. The most highly upregulated gene (5.5-fold) hybridized with an expressed sequence tag on a cDNA microarray, which was sequenced and found to correspond with an endogenous murine retrovirus related to the Duplan strain (EDV, L08395). NZB/… Show more

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Cited by 17 publications
(7 citation statements)
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References 46 publications
(40 reference statements)
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“…Some of these have used animal models, such as for alopecia areata [7] and experimental systemic lupus erythematosus (SLE) [10]. In human autoimmunity, biopsy samples from tissues such as rheumatoid synovium [6,9] and skin [7] have yielded disease insights.…”
Section: Approach To the Study Of Autoimmune Diseasementioning
confidence: 99%
“…Some of these have used animal models, such as for alopecia areata [7] and experimental systemic lupus erythematosus (SLE) [10]. In human autoimmunity, biopsy samples from tissues such as rheumatoid synovium [6,9] and skin [7] have yielded disease insights.…”
Section: Approach To the Study Of Autoimmune Diseasementioning
confidence: 99%
“…Nevertheless, much remains unknown about the pathogenesis of SLE, particularly at the level of nucleic acid accumulation and dysregulated gene expression. Dysregulated gene expression, with the accumulation of aberrant transcripts, could theoretically contribute to apoptosis or increased type I interferon expression and has been shown to mimic lupus [4], [5], [6], [7], [8], [9].…”
Section: Introductionmentioning
confidence: 99%
“…21), a highly heterogeneous group in whom clinical manifestations vary widely. In the only reported study carried out using (NZB ϫ NZW)F 1 mice, nephritic kidneys of these mice were compared with kidneys of healthy NZW controls (22). Because SLE is a systemic autoimmune disease, we were interested in the gene expression profile of immune cells, and our analyses of the SLE-prone mouse model were therefore carried out in spleens.…”
Section: Elmann Et Almentioning
confidence: 99%
“…In the only reported such study in (NZB ϫ NZW)F 1 mice, widely used as a model of SLE, the gene profile of nephritic (NZB ϫ NZW)F 1 mouse kidneys was compared with that in kidneys of nondiseased NZW control mice (22). The most highly up-regulated gene (EDV; 5.5-fold) in the kidneys (but not in the spleens) of diseased mice corresponded to an endogenous retrovirus related to the Duplan strain (EDV, L08395).…”
mentioning
confidence: 99%