Promescent Has a Cytotoxic Impact on Fresh Human Sperm In Vitro

Sutton, Melissa; Hunn, Caitlin; Summers-Colquitt, Roxanne B.; Chen, Shu-Hung; Kavoussi, Shahryar K.; Kavoussi, Keikhosrow M.; Kavoussi, Parviz K.

doi:10.1016/j.urology.2017.12.027

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…142 However, these topical agents should be avoided in couples wishing to conceive as they may have direct toxic effects on spermatozoa. 144 A proposed management algorithm for PE is shown in Figure 3.…”

Section: Premature Ejaculationmentioning

confidence: 99%

“…The lidocaine/prilocaine metered dose spray (Fortacin) containing a pure mixture of lidocaine 150 mg/ml and prilocaine 50 mg/ml is the only EMA‐approved topical anaesthetic agent approved for use in PE 142 . However, these topical agents should be avoided in couples wishing to conceive as they may have direct toxic effects on spermatozoa 144 . A proposed management algorithm for PE is shown in Figure 3.…”

Section: Treatment Strategies For Ejd In Diabetic Menmentioning

confidence: 99%

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Understanding and treating ejaculatory dysfunction in men with diabetes mellitus

et al. 2022

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Section: Premature Ejaculationmentioning

confidence: 99%

Section: Treatment Strategies For Ejd In Diabetic Menmentioning

confidence: 99%

Understanding and treating ejaculatory dysfunction in men with diabetes mellitus

et al. 2022

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“…[71] Some of these drugs have a local anesthetic effect and are, therefore, also used to treat PE. [72,73]…”

Section: Pharmacotherapymentioning

confidence: 99%

Progresses in pharmaceutical and surgical management of premature ejaculation

Zhang

et al. 2019

Chinese Medical Journal

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Objective:Premature ejaculation (PE) is regarded as one of the most common male sexual dysfunctions. This review introduced several pharmaceutical and surgical methods for the management of PE. The definition, etiology, behavioral, and psychological therapy of PE were also discussed.Data sources:“Premature,” “ejaculation,” or “sexual dysfuction” were used as the medical subject headings (MeSH) to obtain relevant articles before June 2019 on Pubmed, Google Scholar and CNKI. Most articles used were written in English and several Chinese articles were also cited.Study selection:Full-text articles of retrospective/prospective/randomized controlled trials were analyzed. Animal experiments and letters were excluded.Results:There are four PE sub-types: lifelong PE, acquired PE, natural variable PE, and subjective PE. Behavioral therapy, psychotherapy, medication, topical anesthetics, and surgery are currently used for the treatment of PE. However, all the above treatments have limitations. Therefore, novel ways should be investigated to more efficiently control PE.Conclusions:The pharmaceutical therapy that is currently being used in clinical practice for the management of PE is still the main choice globally due to its good efficacy. Surgery may be a choice for patients who are resistant to medication. However, it should be performed cautiously.

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