Prolymphocytic Leukæmia of B and T Cell Type

Catovsky, Daniel; Okos, A; Wiltshaw, E.; Galetto, J.; Galton, D. A. G.; Stathopoulos, George P.

doi:10.1016/s0140-6736(73)93135-8

Cited by 174 publications

(60 citation statements)

References 15 publications

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“…It has been generally agreed that C3 receptors are only present on the surface of B lymphocytes and monocytes/macrophages [5,26], Recently, however, their presence in some subpopulations of human and mouse T lymphocytes [10,15,27,31], moreover, in a part of human leukemic cells of T cell origin [8,23,27,29,33] has also been described. Conceptually, one can relate these tumors to different stages in the matu ration of thymic lymphoblasts.…”

Section: Discussionmentioning

confidence: 99%

Rat Lymphoid Leukemia of T Cell Type Induced by 7,12-Dimethylbenz(α)anthracene

Péter¹,

F²,

Sugár³

et al. 1982

Oncology

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Lymphoid leukemia induced by 7,12-dimethylbenz(α)anthracene (DMBA) in rats and maintained by serial intraperitoneal transplantations in newborn rats was subjected to immunological and enzymological characterization. The Thy-1 antigen positivity rendered evidence for the T cell origin of the leukemia studied. Expression of cell surface complement binding receptors and patterns of cytoplasmic acid phosphatase and nonspecific acid α-naphthyl acetate esterase enzymes drew the attention to the dominance of lymphoblasts and prolymphocytes.

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Section: Discussionmentioning

confidence: 99%

Rat Lymphoid Leukemia of T Cell Type Induced by 7,12-Dimethylbenz(α)anthracene

Péter¹,

F²,

Sugár³

et al. 1982

Oncology

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“…[13] found that the highest W BC counts were usually associated with spleno- megaly. Subsequently, it was observed that prolymphocytic CLL, which is usually ac companied by massive spleen enlargement, presents with high W BC [4,5,11], Table V compares organomegaly and W BC values at presentation in 219 cases, the 4 leukopenic patients being excluded. Two groups of mean W BC are apparent: one with a maximum of 54.0 X 109/1, the other with means of 83.9 to 175.9 X 109/1.…”

Section: L L With L Eu K O P En Iamentioning

confidence: 99%

“…Recent cytological research has led to the differentiation of individual forms of chronic lymphoid leukemia (C LL): hairy cell [18], T lymphocyte [15] and prolymphocytic leukemia [4,11].…”

mentioning

confidence: 99%

Chronic Lymphoid Leukemia

Paolino¹,

Infelise²,

Rossi³

et al. 1980

Acta Haematol

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223 cases with chronic lymphoid leukemia (CLL) were subjected to a prospective study on the presence of adeno- and splenomegaly at diagnosis and their subsequent variation. Subjects with no initial organ involvement were usually female (76%) and of old age (mean 69.2 years). Adenopathy or combined lymph node and spleen enlargement were inversely proportional to the mean age at diagnosis. Subsequent organ enlargement was noted in 11.7% of patients with no initial organomegaly, splenomegaly in 15% of patients with adenopathy only and adenopathy in 15% of patients with splenomegaly only. Except in the few cases with leukopenia, particularly high leukocyte levels were noted in patients with splenomegaly (with or without adenopathy). Anemia at diagnosis was not related to the degree of organ enlargement. It is suggested that qualitative and also quantitative differences in organomegaly in CLL merit further study to establish their underlying mechanisms. CLL must be seen as something more complex than the simple mechanical expression of progressive lymphocyte accumulation.

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“…[1][2][3] Relevant oncogenes, such as T-cell leukemia-1 gene (TCL-1) and ataxia telangiectasia-mutated gene (ATM) in the case of T-PLL, and TP53 in B-PLL have been identified and shown to play a role in the pathogenesis of these disorders. Despite advances in understanding of the biology and pathogenesis, the prognosis for this group remains poor with early relapse and short overall survival (OS).…”

Section: Introductionmentioning

confidence: 99%