“…In other words, deficient autophagy can be causal to disease, or its failure can be secondary to alterations in other quality control mechanisms. Nonetheless, this pathway seems to be amenable to genetic and pharmacological enhancement, which can reduce tau levels and aggregation, mitigating spreading and neuronal loss [ 193 , 201 , 202 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 ]. Based on these observations, enhancement of autophagy-lysosomal function can have critically relevant therapeutic implications [ 159 , 195 , 202 , 212 , 213 , 214 , 215 , 216 , 217 ].…”