Prolonged survival when temozolomide is added to accelerated radiotherapy for glioblastoma multiforme

Gückenberger, Matthias; Mayer, Mario Gustavo; Buttmann, Mathias; Vince, Giles Hamilton; Sweeney, Reinhart A.; Flentje, Michael

doi:10.1007/s00066-011-2242-6

Cited by 18 publications

(11 citation statements)

References 30 publications

(30 reference statements)

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“…Nevertheless, the results are not satisfying with median survival times of 12-14 months [7,9,26]. However, radiation therapy is the most effective postsurgical treatment and leads to a doubling of the survival time [29].…”

Section: Results Of a Prospective Phase II Studymentioning

confidence: 99%

Integrated boost IMRT with FET-PET-adapted local dose escalation in glioblastomas

et al. 2012

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Section: Results Of a Prospective Phase II Studymentioning

confidence: 99%

Integrated boost IMRT with FET-PET-adapted local dose escalation in glioblastomas

et al. 2012

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“…However, because outpatient treatment may be quite burdensome given the frequency of treatments, considerations for quality of life should be a point of discussion. 92 …”

Section: Tmz and Radiation Therapymentioning

confidence: 99%

Temozolomide and Other Potential Agents for the Treatment of Glioblastoma Multiforme

Nagasawa

Chow

Yew

et al. 2012

Neurosurgery Clinics of North America

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“…Despite standard treatments consisting of surgery, postoperative radiotherapy and temozolomide (TMZ), patient survival remains poor, mainly attributed to tumor inherent radio- and chemoresistance [17], [18]. Despite the continuous improvements in the treatment of GBM during the past decade, these tumors are still associated with a poor prognosis and a rare long-term survival of the patients [19], [20]. Therefore, there is a great need to understand the underlying mechanisms of tumor progression in order to define novel therapeutic targets for GBM.…”

Section: Introductionmentioning

confidence: 99%

Polish Natural Bee Honeys Are Anti-Proliferative and Anti-Metastatic Agents in Human Glioblastoma multiforme U87MG Cell Line

et al. 2014

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Honey has been used as food and a traditional medicament since ancient times. However, recently many scientists have been concentrating on the anti-oxidant, anti-proliferative, anti-inflammatory and other properties of honey. In this study, we investigated for the first time an anticancer effect of different honeys from Poland on tumor cell line - glioblastoma multiforme U87MG. Anti-proliferative activity of honeys and its interferences with temozolomide were determined by a cytotoxicity test and DNA binding by [H3]-thymidine incorporation. A gelatin zymography was used to conduct an evaluation of metalloproteinases (MMP-2 and MMP-9) expression in U87MG treatment with honey samples. The honeys were previously tested qualitatively (diastase activity, total phenolic content, lead and cadmium content). The data demonstrated that the examined honeys have a potent anti-proliferative effect on U87MG cell line in a time- and dose-dependent manner, being effective at concentrations as low as 0.5% (multifloral light honey - viability 53% after 72 h of incubation). We observed that after 48 h, combining honey with temozolomide showed a significantly higher inhibitory effect than the samples of honey alone. We observed a strong inhibition of MMP-2 and MMP-9 for the tested honeys (from 20 to 56% and from 5 to 58% compared to control, respectively). Our results suggest that Polish honeys have an anti-proliferative and anti-metastatic effect on U87MG cell line. Therefore, natural bee honey can be considered as a promising adjuvant treatment for brain tumors.

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Prolonged survival when temozolomide is added to accelerated radiotherapy for glioblastoma multiforme

Abstract: TMZ added to accelerated radiotherapy for GBM resulted in prolonged overall survival with low rates of severe hematological toxicity.

Cited by 18 publications

References 30 publications

Integrated boost IMRT with FET-PET-adapted local dose escalation in glioblastomas

Integrated boost IMRT with FET-PET-adapted local dose escalation in glioblastomas

Temozolomide and Other Potential Agents for the Treatment of Glioblastoma Multiforme

Polish Natural Bee Honeys Are Anti-Proliferative and Anti-Metastatic Agents in Human Glioblastoma multiforme U87MG Cell Line

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