Prolonged Survival in Lymphangitic Carcinomatosis

Schwarz, Marvin I.; Waddell, Louis C.; Dombeck, David H.; Weill, Hans; Ziskind, Morton M.

doi:10.7326/0003-4819-71-4-779

Cited by 18 publications

(2 citation statements)

References 13 publications

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“…1 had been made premortem, and the patient treated with castration or estrogen therapy. A case of adenocarcinoma of the prostate with lymphangitic carcinomatosis and dyspnea was successfully treated with castration by Schwartz et al 29 Emirgil et a1.I2 reported a short-lived response to prednisone treatment in a patient with lymphangitic carcinomatosis from a carcinoma of the breast. Bagshawe and Brooks5 treated two patients with choriocarcinoma tumor emboli using methotrexate and 6-mercap topurine, with excellent clinical improvement.…”

Section: Vol 36mentioning

confidence: 99%

Pulmonary Tumor Emboli

Kane

Hawkins

Miller

et al. 1975

Cancer

189

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A syndrome is described in which severe, clinically unexplained dyspnea is found at autopsy to be caused by multiple microscopic tumor emboli. Such a situation was found in 8 of 16 cases of multiple microscopic tumor emboli in the pulmonary arteries without significant lymphatic or parenchymal involvement of the lungs. The origins of tumor emboli included carcinomas of the prostate, breast, stomach, pancreas, and liver. In the 8 cases that presented with unexplained dyspnea, initial physical, roentgenographic, and electro‐cardiographic examinations were not diagnostic. Clinical or morphological evidence of cor pulmonale was present in only 5 of these 8 cases. The tumor emboli did not invade the walls of pulmonary vessels but were frequently associated with thrombi. Recognition of this clinicopathologic entity becomes important as progress is made in cancer therapy.

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Section: Vol 36mentioning

confidence: 99%

Pulmonary Tumor Emboli

Kane

Hawkins

Miller

et al. 1975

Cancer

189

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“…Pulmonary lymphangitic spread of prostate cancer that is confirmed pathologically via lung biopsy is rarely reported. To our knowledge, only 7 cases described biopsy-proven lymphangitic metastasis from prostate cancer, but surprisingly none occurred in the castration-resistant setting (Table 1) [2–8]. We describe a rare case of biopsy-proven pulmonary lymphangitic metastasis in the castration-resistant setting.…”

Section: Discussionmentioning

confidence: 87%

Lymphangitic Pulmonary Metastases in Castrate-Resistant Prostate Adenocarcinoma

Meyer

Mariani

Nabhan

2012

Case Reports in Medicine

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A 63-year-old man with castrate-resistant metastatic prostate adenocarcinoma with known osseous and pelvic nodal involvement presented with progressive dyspnea for one week. Complete cardiopulmonary evaluation revealed a restrictive lung defect that could not be attributed to any of his previous therapies. On presentation, physical examination revealed coarse breath sounds diffusely with hypoxemia. Computed tomography of the chest showed severe bilateral airspace opacities and ground-glass appearance most consistent with interstitial pneumonitis. The patient was intubated due to progressive hypoxemia and worsening respiratory status despite empiric antibiotics and high dose steroids. Subsequent emergent bronchoscopy with transbronchial biopsies revealed atypical intralymphatic cells that stained positively for prostate-specific antigen and prostatic-specific acid phosphatase, confirming the diagnosis of intralymphatic pulmonary metastasis from prostate adenocarcinoma. Lymphangitic pulmonary metastasis from prostate adenocarcinoma is exceedingly rare, with few reported cases that are biopsy-proven. Herein, we describe a rare case of biopsy-proven lymphangitic pulmonary metastasis in the setting of castrate-resistant prostate adenocarcinoma and provide a comprehensive literature review.

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Subacute Cor Pulmonale due to Tumor Cell Pulmonary Embolization

Cheng¹

1989

Arch Intern Med

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Prolonged Survival in Lymphangitic Carcinomatosis

Cited by 18 publications

References 13 publications

Pulmonary Tumor Emboli

Pulmonary Tumor Emboli

Lymphangitic Pulmonary Metastases in Castrate-Resistant Prostate Adenocarcinoma

Subacute Cor Pulmonale due to Tumor Cell Pulmonary Embolization

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