Prolonged Stimulation-Induced Pro-Apoptotic B Cells and Deficits in the Germinal Center Formation of Memory B Cells within One Year after Allogeneic HSCT

Abstract

overall survival (OS) was 54% (95% CI, 41e66%) for the entire cohort with an OS for NNGF of 73% (95% CI, 55 e 85%) and for NGF OS was 30% (95% CI, 14e47%) (p<0.01). A second GF occurred in 18 (67%) NGF and in 9 (26%) NNGF patients. Viral studies showed there was more frequent HHV6 reactivation, with 48% of the NGF group versus 8.8% of the NNGF group (p < 0.01) having reactivation. EBV and CMV reactivate was not different. The most common cause of death after second HCT was persisting GF leading to infection or infection despite engraftment. Outcomes of second HCT for NGF and NNGF are different with very poor outcomes for the NGF group, necessitating new approaches to improve overall survival.Abstracts / Biol Blood Marrow Transplant 21 (2015) S147eS170 S167