Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses

Aho, Velma; Ollila, Hanna; Kronholm, Erkki; Bondia‐Pons, Isabel; Soininen, Pasi; Kangas, Antti J.; Hilvo, Mika; Seppälä, Ilkka; Kettunen, Johannes; Oikonen, Mervi; Raitoharju, Emma; Hyötyläinen, Tuulia; Kähönen, Mika; Viikari, Jorma; Härmä, Mikko; Sallinen, Mikael; Olkkonen, Vesa M.; Alenius, Harri; Jauhiainen, Matti; Paunio, Tiina; Lehtimäki, Terho; Salomaa, Veikko; Orešič, Matej; Raitakari, Olli T.; Ala‐Korpela, Mika; Porkka‐Heiskanen, Tarja

doi:10.1038/srep24828

Cited by 82 publications

(72 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings regarding the influence of sleep quality on cholesterol levels is somewhat in concordance with other studies, which have found that poor sleep quality is associated with low HDL cholesterol60 ) , that sleep disturbances increase cholesterol levels61 ) , and that poor sleep quality increases risk of cardiovascular disease62 ) , although some studies have failed to find relationships between sleep quality and cholesterol levels26 ) . Similarly, multiple studies have found relationships between short sleep duration and cholesterol levels36 ) , including decreased HDL cholesterol37, 63 ) , increased LDL cholesterol25, 37 ) , and increased total cholesterol27, 29 ) . Other studies, none of which investigate long-haul truck drivers, have reported a curvilinear relationship between sleep duration and cholesterol levels26, 28 ) .…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Work, sleep, and cholesterol levels of U.S. long-haul truck drivers

et al. 2017

View full text Add to dashboard Cite

Long-haul truck drivers in the United States experience elevated cardiovascular health risks, possibly due to hypercholesterolemia. The current study has two objectives: 1) to generate a cholesterol profile for U.S. long-haul truck drivers; and 2) to determine the influence of work organization characteristics and sleep quality and duration on cholesterol levels of long-haul truck drivers. Survey and biometric data were collected from 262 long-haul truck drivers. Descriptive analyses were performed for demographic, work organization, sleep, and cholesterol measures. Linear regression and ordinal logistic regression analyses were conducted to examine for possible predictive relationships between demographic, work organization, and sleep variables, and cholesterol outcomes. The majority (66.4%) of drivers had a low HDL (<40 mg/dL), and nearly 42% of drivers had a high-risk total cholesterol to HDL cholesterol ratio. Sleep quality was associated with HDL, LDL, and total cholesterol, and daily work hours were associated with LDL cholesterol. Workday sleep duration was associated with non-HDL cholesterol, and driving experience and sleep quality were associated with cholesterol ratio. Long-haul truck drivers have a high risk cholesterol profile, and sleep quality and work organization factors may induce these cholesterol outcomes. Targeted worksite health promotion programs are needed to curb these atherosclerotic risks.

show abstract

Section: Discussionmentioning

confidence: 92%

“…Endocrine functioning is impacted by sleep, which influences various metabolic processes, including lipid metabolism, by altering levels of hormones such as thyrotropin and cortisol34, 35, 36 ) . Sleep may also impact genes responsible for cholesterol transportation37 ) . Other mechanisms are more indirect.…”

Section: Introductionmentioning

confidence: 99%

Work, sleep, and cholesterol levels of U.S. long-haul truck drivers

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Sleep Restriction and Sleep Architecture: Impact On The Metsmentioning

confidence: 99%

“…Very recently, an experimental partial sleep restriction study of 14 subjects vs seven controls found that sleep restriction decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses, although circulating LDL decreased rather than increased in the sleep-restricted subjects 182. Metabolomic analyses in 2,739 adults also found that those reporting chronically insufficient sleep had lower circulating large LDL 182. These findings suggest that while the impact on lipids is not necessarily apparent in acute sleep restriction, prolonged or chronic sleep deprivation can modify inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes that increase cardiometabolic risk.…”

Section: Sleep Restriction and Sleep Architecture: Impact On The Metsmentioning

confidence: 99%

Role of sleep quality in the metabolic syndrome

Koren¹,

Dumin²,

Gozal³

2016

DMSO

142

View full text Add to dashboard Cite

Emerging evidence has assigned an important role to sleep as a modulator of metabolic homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and chronotype to cardiometabolic function encompasses a wide array of perturbations spanning from obesity, insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease risk and mortality in both adults and children. Here, we critically and extensively review the published literature on such important issues and provide a comprehensive overview of the most salient pathophysiologic pathways underlying the links between sleep, sleep disorders, and cardiometabolic functioning.

show abstract

“…Insufficient sleep contributes to an increased incidence of cardiovascular, metabolic and neurodegenerative diseases (Banks and Dinges, 2007; Mullington et al, 2009; Aho et al, 2016). Chronic restricted sleep also results in decrements in memory and performance (Alhola and Polo-Kantola, 2007; Goel et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Chronic sleep deprivation differentially affects short and long-term operant memory in Aplysia

Krishnan

Noakes

Lyons

2016

Neurobiology of Learning and Memory

View full text Add to dashboard Cite

The induction, formation and maintenance of memory represent dynamic processes modulated by multiple factors including the circadian clock and sleep. Chronic sleep restriction has become common in modern society due to occupational and social demands. Given the impact of cognitive impairments associated with sleep deprivation, there is a vital need for a simple animal model in which to study the interactions between chronic sleep deprivation and memory. We used the marine mollusk Aplysia californica, with its simple nervous system, nocturnal sleep pattern and well-characterized learning paradigms, to assess the effects of two chronic sleep restriction paradigms on short-term (STM) and long-term (LTM) associative memory. The effects of sleep deprivation on memory were evaluated using the operant learning paradigm, learning that food is inedible, in which the animal associates a specific netted seaweed with failed swallowing attempts. We found that two nights of 6 h sleep deprivation occurring during the first or last half of the night inhibited both STM and LTM. Moreover, the impairment in STM persisted for more than 24 hours. A milder, prolonged sleep deprivation paradigm consisting of 3 consecutive nights of 4 h sleep deprivation also blocked STM, but had no effect on LTM. These experiments highlight differences in the sensitivity of STM and LTM to chronic sleep deprivation. Moreover, these results establish Aplysia as a valid model for studying the interactions between chronic sleep deprivation and associative memory paving the way for future studies delineating the mechanisms through which sleep restriction affects memory formation.

show abstract

Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses

Cited by 82 publications

References 91 publications

Work, sleep, and cholesterol levels of U.S. long-haul truck drivers

Work, sleep, and cholesterol levels of U.S. long-haul truck drivers

Role of sleep quality in the metabolic syndrome

Chronic sleep deprivation differentially affects short and long-term operant memory in Aplysia

Contact Info

Product

Resources

About