Prolonged Recording of Duodenal Acid Exposure in Patients With Functional Dyspepsia and Controls Using a Radiotelemetry pH Monitoring System

Bratten, Jason; Jones, Michael P.

doi:10.1097/mcg.0b013e31818e37ab

Cited by 56 publications

(39 citation statements)

References 13 publications

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“…Overall, fluctuations because of food in pH of the intestinal system are reported to be less dramatic and may cause the pH to lower by 1 [137]. Both are subject to inter-and intra-individual variations [138]. The presence of fat in food slows gastric emptying and such prolongs the residence time in the stomach [139,140].…”

Section: Foodmentioning

confidence: 98%

Variability in bioavailability of small molecular tyrosine kinase inhibitors

Herbrink

Nuijen

Schellens

et al. 2015

Cancer Treatment Reviews

110

104

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Section: Foodmentioning

confidence: 98%

Variability in bioavailability of small molecular tyrosine kinase inhibitors

Herbrink

Nuijen

Schellens

et al. 2015

Cancer Treatment Reviews

110

104

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“…A 24-hour ambulatory duodenal pH monitoring has shown increased spontaneous duodenal acid exposure in FD patients 8,19. Duodenal acid exposure is reported to be significantly increased in FD patients during the daytime and after a meal.…”

Section: Abnormal Responses To Duodenal Acid In Fdmentioning

confidence: 99%

Duodenal Implications in the Pathophysiology of Functional Dyspepsia

Lee¹,

Tack²

2010

J Neurogastroenterol Motil

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Functional dyspepsia (FD) is a heterogeneous disorder associated with diverse pathophysiologic mechanisms. Studies have shown duodenal implications in the pathophysiology of FD. Duodenal hypersensitivity to acid, increased duodenal acid exposure, and abnormal responses to duodenal lipids or released cholecystokinin have been observed in patients with FD. Moreover, there is evidence indicating duodenal immune activation in FD. Alterations in the number of duodenal eosinophils or intraepithelial lymphocytes have been reported in a subset of FD patients, particularly in patients with post-infectious FD. Whether these abnormalities in the duodenum play a crucial role in the generation of dyspeptic symptoms needs to be elucidated. Further investigations on the relationship between duodenal abnormalities and well-known pathophysiologic mechanisms of FD are required. Furthermore, the causative factors related to the development of duodenal abnormalities in FD warrant further study.

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“…Direct infusion of hydrochloric acid into the duodenum was also found to cause dyspeptic symptoms and confirmed the role of duodenal acidification as a mechanism of their generation. In patients with FD, intraduodenal pH was reported to be lower than that in asymptomatic controls, and acidic contents infused into the duodenum were not effectively emptied by duodenal motor activities [35][36][37][38]. Several clinical studies have focused on the therapeutic effects of proton pump inhibitors (PPIs) on various types of dyspeptic symptoms, including epigastralgia, epigastric burning, postprandial fullness, and early satiation, and the results of these studies confirmed that the inhibition of gastric acid secretion relieved many types of dyspeptic symptoms in patients with FD as well as in those with uninvestigated dyspepsia [39].…”

Section: Discussionmentioning

confidence: 97%