Prolonged QT dispersion in inflammatory bowel disease

Yorulmaz, Elif; Sezgin, Aslıhan; Yorulmaz, Hatice; Adali, Güpse; Çiftçi, Hilmi

doi:10.3748/wjg.v19.i1.65

Cited by 8 publications

(12 citation statements)

References 33 publications

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“…Figure 4 shows the PRISMA diagram summarizing the sequence of the literature selection. Seven studies reported on QTc interval [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Table 3 summarizes the results of the studies that measured the QTc interval in patients with IBD.…”

Section: Resultsmentioning

confidence: 99%

“…Population-based studies demonstrate that disease activity in IBD is associated with an increased risk of morbidity and mortality due to CVD [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Furthermore, a number of observations indicate that patients with IBD are at a higher risk of developing ECG abnormalities, i.e., QTc interval [ 21 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. QTc interval represents the most investigated ECG parameter in patients with IBD [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Figure 4 shows the PRISMA diagram summarizing the sequence of the literature selection. Seven studies reported on QTc interval [27][28][29][30][31][32][33]. Table 3 There were no significant relationships between the QTc values and all the other baseline characteristics, i.e., gender, age, disease duration, type of IBD (UC or CD), and therapy.…”

Section: Systematic Reviewmentioning

confidence: 99%

“…Notably, morbidity and mortality due to CVD are exclusively observed during active IBD flares. Studies based on electrocardiogram (ECG) findings indicate that patients with IBD are at a higher risk of developing QT interval abnormalities, in particular heart-rate-corrected QT interval (QTc) [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases

et al. 2020

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Background and objectives: Electrocardiograph abnormalities (i.e., QT interval prolongation) have been described in inflammatory bowel diseases (IBD). We aimed to measure the QT interval in a cohort of patients with IBD and to analyze its relationship with clinical and inflammatory activity. Materials and Methods: We performed a cross-sectional study that included 38 IBD outpatients and 38 “age- and sex-matched” healthy controls. Nine patients had active IBD, and 29 were in clinical remission. Among the latter, 10 patients had sustained (lasting >1 year) and 19 had short-term remission (≤1 year). Corrected QT (QTc) interval was measured on standard 12-lead electrocardiograph. A systematic review of the literature on studies investigating the QT interval in patients with IBD was also performed. Results: QTc interval values were similar between IBD patients and healthy controls (417.58 ± 22.05 ms vs. 409.13 ± 19.61 ms, respectively; p: 0.479). Patients with active IBD had significantly higher QTc values (435.11 ± 27.31 ms) than both controls (409.13 ± 19.61 ms) and patients in remission (412.14 ± 17.33 ms) (p: 0.031). Post hoc analysis showed that the difference in QTc values between active IBD and remission was attributable to the group of patients with sustained remission (p < 0.05). Lastly, a significant correlation between QTc interval and C-reactive protein (CRP) values was observed (Spearman test: r = 0.563; p: 0.0005). Conclusions: Our study demonstrates an association between QTc duration and both clinical and inflammatory activity in patients with IBD. The higher the CRP value, the longer is the QTc duration. For practical purposes, all patients with active IBD should undergo a standard ECG. Prescription of drugs able to modify the QT interval should be avoided in patients with active IBD. The systematic review of the literature indicated that this is the first published study demonstrating an association between the QTc duration and CRP values in patients with IBD.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Systematic Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases

et al. 2020

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“…Therefore, UC and CD can show similar autonomic and ECG alternations owing to their same mechanisms of tissue damage [32]. …”

Section: Discussionmentioning

confidence: 99%

Prolonged P-Wave and QT Dispersion in Children with Inflammatory Bowel Disease in Remission

Bornaun

Yılmaz

Kutluk

et al. 2017

BioMed Research International

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Objectives. Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) with unclear underlying aetiologies. Severe cardiac arrhythmias have been emphasised in a few studies on adult IBD patients. This study aimed to investigate the alteration of the P-wave and QT interval dispersion parameters to assess the risk of atrial conduction and ventricular repolarisation abnormalities in pediatric IBD patients. Patients and Methods. Thirty-six IBD patients in remission (UC: 20, CD: 16) aged 3–18 years and 36 age- and sex-matched control patients were enrolled in the study. Twelve-lead electrocardiograms were used to determine durations of P-wave, QT, and corrected QT (QTc) interval dispersion. Transthoracic echocardiograms and 24-hour rhythm Holter recordings were obtained for both groups. Results. The P-wave dispersion, QT dispersion, and QTc interval dispersion (Pdisp, QTdisp, and QTcdisp) were significantly longer in the patient group. The mean values of Pminimum, Pmaximum, and QTcminimum were significantly different between the two groups. The echocardiography and Holter monitoring results were not significantly different between the groups. Furthermore, no differences in these parameters were detected between the CD and UC groups. Conclusion. Results suggest that paediatric IBD patients may carry potential risks for serious atrial and ventricular arrhythmias over time even during remission.

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Mendelian Diseases and Inflammatory Bowel Disease—Data Mining for Genetic Risk and Disease-Associated Confounders

Uhlig

2018

Inflammatory Bowel Diseases

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Prolonged QT dispersion in inflammatory bowel disease

Abstract: Our data show that IBD patients have prolonged QTcd in relation to controls. The routine follow-up of IBD patients should include determination of HOMA, insulin values and electrocardiogram examination.

Cited by 8 publications

References 33 publications

Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases

Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases

Prolonged P-Wave and QT Dispersion in Children with Inflammatory Bowel Disease in Remission

Mendelian Diseases and Inflammatory Bowel Disease—Data Mining for Genetic Risk and Disease-Associated Confounders

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