Prolonged persistence of SARS-CoV-2 in the upper respiratory tract of asymptomatic infected individuals

Saurabh, Suman; Kumar, Ritesh; Gupta, Manoj Kumar; Bhardwaj, Pankaj; Nag, Vijaya Lakshmi; Garg, Mahendra Kumar; Misra, Sanjeev

doi:10.1093/qjmed/hcaa212

Cited by 16 publications

(15 citation statements)

References 10 publications

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“…As for f, the mean duration of infectious period is a debatable point. In [27], the authors estimate that the asymptomatic individuals had median virus persistence duration of 8.87 days (95% confidence interval 7.65-10.27). This duration varies also between asymptomatic and symptomatic individuals [28], even when mildly affected.…”

Section: Discussionmentioning

confidence: 99%

A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France

Zongo¹,

Zorom

Mophou

et al. 2020

Epidemiol. Infect.

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The main objective of this paper is to address the following question: are the containment measures imposed by most of the world governments effective and sufficient to stop the epidemic of COVID-19 beyond the lock-down period? In this paper, we propose a mathematical model which allows us to investigate and analyse this problem. We show by means of the reproductive number, R 0 that the containment measures appear to have slowed the growth of the outbreak. Nevertheless, these measures remain only effective as long as a very large fraction of population, p, greater than the critical value 1 − 1/R 0 remains confined. Using French current data, we give some simulation experiments with five scenarios including: (i) the validation of model with p estimated to 93%, (ii) the study of the effectiveness of containment measures, (iii) the study of the effectiveness of the large-scale testing, (iv) the study of the social distancing and wearing masks measures and (v) the study taking into account the combination of the large-scale test of detection of infected individuals and the social distancing with linear progressive easing of restrictions. The latter scenario was shown to be effective at overcoming the outbreak if the transmission rate decreases to 75% and the number of tests of detection is multiplied by three. We also noticed that if the measures studied in our five scenarios are taken separately then the second wave might occur at least as far as the parameter values remain unchanged.

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Section: Discussionmentioning

confidence: 99%

A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France

Zongo¹,

Zorom

Mophou

et al. 2020

Epidemiol. Infect.

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show abstract

“…The overall median persistence of the virus for both symptomatic and asymptomatic individuals was found to be 9.18 days (between 8.04 and 10.48 with a 95% Confidence Level). However, a significant proportion of asymptomatic people (around 25%) gave a positive result after 2 weeks of tests, which is indicative of the persistence of SARS-Cov-2 in the nasal passages and thus the potential for transmission during that period [85]. These findings have implications for public health: how and when to come out of isolation needs to be carefully regulated, given the evidence that a single negative result is insufficient.…”

Section: Evolution Of Viral Load Versus Time and Risk Of False Negativesmentioning

confidence: 99%

Reliability of real-time RT-PCR tests to detect SARS-Cov-2: A literature review

Bezier

Anthoine²,

Charki

2020

Int. J. Metrol. Qual. Eng.

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In the face of the COVID-19 (Coronavirus Disease 2019) pandemic, the World Health Organization (WHO) has urged countries to test the population more widely. Clinical laboratories have been confronted with a huge demand for testing and have had to make urgent preparations for staff training, to establish new analytical processes, reorganize the workspace, and stock up on specific equipment and diagnostic test kits. The reliability of SARS-Cov-2 test results is of critical importance, given the impact it has on patient care and the management of the health crisis. A review of the literature available for the period leading up to and including June 2020 on the reliability of SARS-Cov-2 (Severe Acute Respiratory Syndrome Coronavirus) detection methods using real-time RT PCR (Reverse Transcription - Polymerase Chain Reaction) brings together the primary factors teams of scientists claim or demonstrate to affect the reliability of results. A description is given of the RT-PCR testing method, followed by a presentation of the characteristics and validation techniques used. A summary of data from the literature on the reliability of tests and commercial kits for SARS-Cov-2 detection, including current uncertainties with regard to the molecular targets selected and genetic diversity of SARS-Cov-2 is provided. The limitations and perspectives are then discussed in detail in the light of the bibliographic data available. Many questions have been asked that still remain unanswered. The lack of knowledge about this novel virus, which appeared at the end of 2019, has a significant impact on the technical capacity to develop reliable, rapid and practical tools for its detection.

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“…The median persistence of the virus among asymptomatic COVID-19 cases has been reported to be approximately 9 days, with around a quarter of cases showing viral persistence beyond 2 weeks. 8 Early identification and isolation of active cases, potential sources and carriers, and eliminating routes of transmission are important ways to control the COVID-19 pandemic. Global testing strategies focus on screening of symptomatic individuals and contact tracing in some countries.…”

Section: Introductionmentioning

confidence: 99%

Persistent positivity of SARS-CoV-2 nucleic acid in asymptomatic healthcare worker: infective virion or inactive nucleic acid?

et al. 2021

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Asymptomatic individuals positive for SARS-CoV-2 RNA constitute a significant proportion of the infected population and play a role in the transmission of the virus. We describe a healthcare worker who presented with fever and malaise and was diagnosed with mild COVID-19. The symptoms resolved within 4 days but there was persistent positivity of viral RNA in the upper respiratory tract for more than 58 days, which is the longest reported duration of persistence of SARS-CoV-2 in a healthcare worker. In this case report, we discuss clinical and administrative issues such as the role of asymptomatic cases in the transmission of the virus to patients and coworkers as an occupational hazard, interpretation of persistent positivity of nucleic acid test, duration of isolation and return-to-work guidelines pertinent to researchers and global health policymakers.

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Prolonged persistence of SARS-CoV-2 in the upper respiratory tract of asymptomatic infected individuals

Abstract: Summary Background Duration of persistence of SARS-CoV-2 in the upper respiratory tract of infected individuals has important clinical and epidemiological implications. Aim We aimed to establish the duration and risk factors for persistence of SARS-CoV-2 in the up… Show more

Cited by 16 publications

References 10 publications

A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France

A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France

Reliability of real-time RT-PCR tests to detect SARS-Cov-2: A literature review

Persistent positivity of SARS-CoV-2 nucleic acid in asymptomatic healthcare worker: infective virion or inactive nucleic acid?

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