Prolonged oro‐facial dystonia in a 58 year old female following therapy with bupropion and St John's Wort

Milton, James C.; Abdulla, Aza

doi:10.1111/j.1365-2125.2007.02962.x

Cited by 14 publications

(6 citation statements)

References 6 publications

(9 reference statements)

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“…For example, there are several case reports that describe acute dystonias with bupropion exposure (e. g., bilateral trismus, inability to rotate one ' s head laterally, oro-facial dystonia) [3,4,7] . Iskandar and colleagues [6] described a case of bupropion-related rhabdomyolysis, which was associated with an elevation in CPK levels but not with focalized muscle pain.…”

mentioning

confidence: 99%

Bupropion-Induced Neck and Shoulder Pain

Sansone¹,

Sansone²

2009

Pharmacopsychiatry

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confidence: 99%

Bupropion-Induced Neck and Shoulder Pain

Sansone¹,

Sansone²

2009

Pharmacopsychiatry

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“…A typical pharmacodynamic interaction with SJW was also reported in a patient who had been on SJW for several years and then developed orofacial dystonia following the concurrent use of bupropion [ 40 ]. The combination was believed to exert additive inhibition of serotonin reuptake, with additional enhanced dopaminergic effects such as dystonia.…”

Section: Resultsmentioning

confidence: 97%

Herb-drug Interactions in Neuropsychiatric Pharmacotherapy – A Review of Clinically Relevant Findings

McGrath

Fasinu

2022

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: The management of neuropsychiatric disorders relies heavily on pharmacotherapy. The use of herbal products as complimentary medicine, often concomitantly, is common among patients taking prescription neuropsychiatric drugs. Herb-drug interaction, a clinical consequence of this practice, may jeopardize the success of pharmacotherapy in neuropsychiatry. Besides the well-known ability of phytochemicals to inhibit and/or induce drug-metabolizing enzymes and transport proteins, several phytoconstituents are capable of exerting pharmacological effects on the central nervous system. The consequent pharmacokinetic and pharmacodynamic interactions with orthodox medications often result in deleterious clinical consequences. This study reviewed the relevant literature and identified 13 commonly used herbal products – celery, echinacea, ginkgo, ginseng, hydroxycut, kava, kratom, moringa, piperine, rhodiola, St John’s wort, terminalia/commiphora ayurvedic mixture and valerian – which have shown clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders. The clinical focus is aimed to provide easily accessible information that will be of interest to clinicians, researchers, and the drug-consuming public.

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“…Risk factors include male gender, young generation, high dosage, high potency antipsychotics, and parenteral administration of antipsychotics. [ 10 11 12 13 14 ]…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors include male gender, young generation, high dosage, high potency antipsychotics, and parenteral administration of antipsychotics. [10][11][12][13][14] The serotonergic system has many problematic interactions with a variety of different receptor subtypes such as gamma amino butyric acid and the cholinergic system. Toxic inhibitory effects on dopaminergic function via serotonergic neurons in the brainstem and impaired dopamine/acetylcholine balance, justifies SSRIs as a cause of acute dystonia.…”

Section: Discussionmentioning

confidence: 99%

Acute Dystonia After Single Dose of Bupropion

Elyasi¹,

Mahtiyan

2016

Indian Journal of Psychological Medicine

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Bupropion is an antidepressant that is effective in the treatment of major depressive disorders, smoking cessation, and sexual side effects of selective serotonin reuptake inhibitors. Acute dystonia is characterized by prolonged muscle contraction often represented by spasms of the head and neck muscles as well as occasional jaw clenching and temporomandibular joint syndrome. Although it is believed that dystonia is the result of an abnormality of the basal ganglia, its pathophysiology is still unclear. A few cases of dystonia resulting from bupropion have been reported in prior research papers. This case report discusses a patient who had a neck spasm painful enough to wake him up and dystonic distortion after taking only one dose of 75 mg bupropion. The patient was a young 34-year-old man with a diagnosis of obsessive-compulsive disorder treated with 60 mg fluoxetine. Bupropion was added to his medications because of sexual side effects caused by the fluoxetine. It seems that we must be careful to watch for dystonic symptoms when bupropion is mixed with other drugs that affect serotonin reuptake. Although dystonia is a rare side effect of bupropion, physicians should be aware of it and manage it if it occurs.

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Prolonged oro‐facial dystonia in a 58 year old female following therapy with bupropion and St John's Wort

Cited by 14 publications

References 6 publications

Bupropion-Induced Neck and Shoulder Pain

Bupropion-Induced Neck and Shoulder Pain

Herb-drug Interactions in Neuropsychiatric Pharmacotherapy – A Review of Clinically Relevant Findings

Acute Dystonia After Single Dose of Bupropion

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