Prolonged organophosphate toxicity in a twenty-six-month-old child

Organophosphate poisoning complicated by a tachyarrhythmia and acute respiratory distress syndrome in a child

“…have also suggested that the effects of organophosphate poisoning in children differ from those in adults, due to predominantly central nervous system features, although they and others have documented respiratory failure requiring ventilation in 8−38% of affected children 5−7 . Only a single adult case report has documented ARDS following organophosphate exposure and there have been no reports in children 1−11 …”

“…The few reports in children have demonstrated much lower mortality rates; in the region of 0−3% 5−7 . While respiratory complications including pulmonary oedema are common, acute respiratory distress syndrome (ARDS) following organophosphate poisoning is rare but potentially fatal 1−11 …”

Severe fenthion intoxications due to ingestion and inhalation with survival outcome

“…Although organophosphates are quickly absorbed through the skin and mucous membranes, 15 signs and symptoms of acute toxicity after dermal exposure appear much later compared to those after ingestion. 14 Moreover, fenthion is known to have a highly cumulative effect, probably due to its high solubility in fat tissue. 19 One may, therefore, assume that the child was being exposed to subtoxic levels of the organophosphate agent throughout the week, resulting in clinical poisoning on the seventh day of spraying.…”

Use of C1300 Neuroblastoma Cells to Evaluate the Protective Value of Hexamethonium, Trimethaphan, Hemicholinium, and Triethylcholine against Diisopropyl Phosphorofluoridate Toxicity

“…The other is atropine, which blocks muscarinic receptors and reduces some toxic cholinergic symptoms. 2 Our intent in this study was to determine if the prophylactic effects of these drugs observed in vivo could be observed and evaluated in an in vitro system. The in vitro system we studied was a C1300 neuroblastoma cell line.13-15 It was found that hexamethonium, hemicholinium, trimethapham, and triethylcholine all exhibit certain degrees of prophylaxis against DFP toxicity in vitro although their prophylactic mechanisms might not all be the same.…”

“…The other is atropine, which blocks muscarinic receptors and reduces some toxic cholinergic symptoms. 2 Our intent in this study was to determine if the prophylactic effects of these drugs observed in vivo could be observed and evaluated in an in vitro system. The in vitro system we studied was a C1300 neuroblastoma cell line.…”