Prolonged Kinetics of Recovery of Oxygen Consumption After Maximal Graded Exercise in Patients With Chronic Heart Failure

Cohen‐Solal, Alain; Laperche, Thierry; Morvan, Daniel; Geneves, Michel; Caviezel, B; Gourgon, R

doi:10.1161/01.cir.91.12.2924

Cited by 172 publications

(199 citation statements)

References 62 publications

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“…Similar findings have been also demonstrated in chronic left heart failure patients. 40,41 These results may indicate an abnormal oxygen delivery to the peripheral tissues mainly from an impaired cardiac output during exercise or peripheral tissue oxidative mechanism impairment. The strong correlation between CR and HRR 1 with peak exercise oxygen uptake BMI, body mass index; FEV 1 , forced expired volume in 1 second; FVC, forced vital capacity; HR, heart rate; %CR, (peak HR-resting HR/220-age-resting HR) Â 100; HRR 1 , the difference between peak HR and HR 1 minute later; VO 2 p, peak oxygen uptake; AT, anaerobic threshold; WRp, peak work rate; VO 2 -t/slope, the first-degree slope of VO 2 for the first minute of recovery; VE/VCO 2 slope, the slope of the ventilatory equivalent for carbon dioxide output; P ET CO 2 , end-tidal expiratory partial pressure for carbon dioxide output; SaO 2 , pulse oxygen saturation; CI, cardiac index; RAP, right atrial pressure; mPAP, mean pulmonary artery pressure; PCWP, pulmonary capillary wedge pressure; i, idiopathic; ii, PAH associated with scleroderma; iii, atrial septal defect; iv, Rendu-Osler-Weber disease.…”

Section: Discussionmentioning

confidence: 98%

Impairment of Autonomic Nervous System Activity in Patients With Pulmonary Arterial Hypertension: A Case Control Study

Dimopoulos¹,

Anastasiou-Nana²,

Katsaros³

et al. 2009

Journal of Cardiac Failure

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Section: Discussionmentioning

confidence: 98%

Impairment of Autonomic Nervous System Activity in Patients With Pulmonary Arterial Hypertension: A Case Control Study

Dimopoulos¹,

Anastasiou-Nana²,

Katsaros³

et al. 2009

Journal of Cardiac Failure

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“…While our data demonstrate that skeletal muscle oxidative capacity is not reduced in our cohort of CHF patients it is possible that the rate of oxidative phosphorylation during exercise is reduced. In vivo studies using P-31 nuclear magnetic resonance (P-31 NMR) spectroscopy have demonstrated reduced phosphocreatine (PCr) resynthesis post-exercise in CHF patients 27,41 . As PCr resynthesis is an oxidative process, this suggests an impaired rate of oxidative phosphorylation.…”

Section: Muscle Fiber Types Muscle Biopsy Studies In Chf Have Consismentioning

confidence: 99%

Reduced exercise tolerance in CHF may be related to factors other than impaired skeletal muscle oxidative capacity

Williams¹,

Selig²,

Hare³

et al. 2004

Journal of Cardiac Failure

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“…Then 50% of that change was calculated and subtracted from the energy expenditure for reading. The calculated oxygen consumption then was compared to oxygen consumption during recovery at one-minute and twominute intervals to identify the number of individuals in each group who achieved 50% recovery at those time points (Scrutinio, Passantino, Lagioia, Napoli, Ricci, & Rizzon, 1998;Cohen-Solal, Laperche, Morvan, Geneves, Caviezel, & Gourgon, 1995).…”

Section: Extraction Of Reading Metabolic Recovery Datamentioning

confidence: 99%

“…Data on EPOC will provide insight into the cardiac output that aids in recovery from exercise -that is, around cardiovascular recovery issues (Cohen-Solal et al, 1995).…”

Section: Descriptive Exploration Of Raw Data (Supplement To Sa 1)mentioning

confidence: 99%

Metabolic Mechanisms of Vocal Fatigue

2017

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Vocal fatigue is among the most debilitating conditions affecting individuals with voice disorders. Impressions about mechanisms potentially underlying vocal fatigue have varied depending on how fatigue is defined, participants studied, and measures made, thereby impacting the selection of treatment strategies that may alleviate the condition. However, little is currently known about actual metabolic mechanisms of vocal fatigue. The current study aimed to address this issue by investigating the hypothesis that neuromuscular inefficiency, cardiovascular recovery deficits, or both, may play a role in fatigue. The approach replicated well-vetted approaches in exercise physiology.Metabolic profiles of subjects with vocal fatigue were assessed using gas exchange measures in comparison to two non-fatigue groups: vocally healthy and cardiovascular trained individuals, recruited based on results from a newly vetted questionnaire, the Vocal Fatigue Index (VFI) and laryngeal examination. Participants read out loud at two different loudness levels for a duration of 5 minutes for each task with periods of rest between tasks. Metabolic cost for and recovery time from reading were same across all groups. Oxygen uptake and recovery kinetics (EPOC), ratings of perceived exertion revealed interesting patterns in individuals with vocal fatigue compared to cardiovascular trained individuals in particular.Specifically, slow oxygen uptake kinetics in the vocal fatigue compared to the cardiovascular iv trained group pointed to utilization of anaerobic energy source to meet the demands of the reading task in the vocal fatigue group, suggesting neuromuscular inefficiency. In contrast, rapid oxygen uptake kinetics in the cardiovascular trained group pointed to utilization of aerobic energy sources and greater neuromuscular efficiency. Similarly, a greater number of individuals in vocal fatigue and vocally healthy groups showed an increase in oxygen consumption post reading (EPOC) compared to the cardiovascular trained group, indicating possible cardiovascular recovery deficits in the former groups.In addition to uncovering potential mechanisms underlying vocal fatigue, including neuromuscular inefficiency and cardiovascular recovery deficits, results from the present study highlight the potential importance of aerobic training to generate aerobic energy required for vocal task demands for both ease of task performance and recovery from it. In sharp contrast to the situation for voice, fatigue as a common physical phenomenon more generally has received extensive attention in the physical therapy, sports medicine, and exercise physiology literature. Three broad schools of thought identify mechanisms pertaining to the origins of physical fatigue: (1) peripheral mechanisms (Allen, Lamb, & Westerblad, 2008;Asmussen, 1979;Edwards, 1981;Fitts, 1994;Westerblad, Allen, & Lannergren, 2002;Westerblad, Lee, Lannergren, & Allen, 1991), (2) The next pages and chapters provide pertinent background information on vocal fatigue, fatigue as understood ...

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Prolonged Kinetics of Recovery of Oxygen Consumption After Maximal Graded Exercise in Patients With Chronic Heart Failure

Cited by 172 publications

References 62 publications

Impairment of Autonomic Nervous System Activity in Patients With Pulmonary Arterial Hypertension: A Case Control Study

Impairment of Autonomic Nervous System Activity in Patients With Pulmonary Arterial Hypertension: A Case Control Study

Reduced exercise tolerance in CHF may be related to factors other than impaired skeletal muscle oxidative capacity

Metabolic Mechanisms of Vocal Fatigue

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