Prolonged functional cerebral asymmetry as a consequence of dysfunctional parvocellular paraventricular hypothalamic nucleus signaling: An integrative model for the pathophysiology of bipolar disorder

Levenberg, Kate; Hajnal, A.; George, Daniel R.; Saunders, Erika F.H.

doi:10.1016/j.mehy.2020.110433

Cited by 5 publications

(2 citation statements)

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“…As neuroendocrine indices of HPT, the abnormal changes of T3, T4, FT3, FT4 and other related thyroid hormones were often associated with more episodes and severe depressive symptoms ( 59 , 60 ), both of them have an influence on psychosocial functioning ( 3 , 27 ). Interestingly, FT4 and TT4 were correlated with the financial domain of subjects in the MF and GF groups, which might link to the mood changes of HPT involvement in BD that performed depressive or hypomanic/manic behaviors corresponding to hyperthyroidism and hypothyroidism ( 61 ). The ALB and TP levels were negatively correlated with interpersonal domain, which may be related to unhealthy physical conditions, such as comorbidities.…”

Section: Discussionmentioning

confidence: 97%

Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables

Chen²,

Lai³

et al. 2022

Front. Psychiatry

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ObjectiveThis study aims to identify the functional heterogeneity in fully or partially remitted patients with bipolar disorder and explore the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables.MethodsOne hundred and forty fully or partially remitted patients with bipolar disorder (BD) and seventy healthy controls were recruited. The patients were grouped into different profiles based on the Functioning Assessment Short Test (FAST) domain scores by hierarchical cluster analysis. The characteristics of subgroups and the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables in each cluster were then analyzed.ResultsThere were three subgroups in fully or partially remitted patients with BD: the lower functioning group (LF), performed global functioning impairments; the moderate functioning group (MF), presented selective impairments in functional domains; and the good functioning subgroup (GF), performed almost intact functioning. Among the three subgroups, there were differences in FAST domains, sociodemographic variables, clinical variables, some neurocognitive domains and several biochemical indexes.ConclusionsThe study successfully identified three functional subgroups. The characteristics of discrete subgroups and the specific clinical factors, neurocognitive domains and biochemical indexes that are correlated with functional subgroups will allow for making tailored interventions to promote functional recovery and improve the quality of life.

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Section: Discussionmentioning

confidence: 97%

Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables

Chen²,

Lai³

et al. 2022

Front. Psychiatry

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“…For individuals with diagnosis of dysthymia characterized by ambivalence of goal with the predominance of instrumental activity aimed at success. For persons with a diagnosis of cyclothymia with type of monophasic flow for hypomanic type is characterized by a positive formulation of goals with accompanying of productive instrumental activity (Levenberg et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Study of the focus of achievement motivation in mental pathology

Tapalova

Zhiyenbayeva

Kamysbayeva

2021

GJPR

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The phenomenon of achievement motivation is very important in psychology, as research explains the driving forces of human behavior and activity. That is why interest in studying the achievement motivation is constantly growing. The authors of this article believe that the content structure of the achievement motivation in humans has two components – adaptive and transcendental. The purpose of this article is to present an experimental study of the meaningful characteristics of achievement motivation in persons with mental pathology. The research method is projective methodology - Hekhauzen test and author's modification of this test for persons with mental pathology, Freiburg multifactorial personality questionnaire, Diagnostics of self-actualization of personality SAMOAL. The obtained results of the study of achievement motivation in persons with mental pathology show that respondents of this category have changes in the motivational-value-semantic sphere, changes are shown in extreme manifestation of one of the tendencies (adaptation or transcendence), or extremely weak representation of both trends. Keywords: achievement, neurotic disorders, affective disorders, adaptation, transcendence, Hekhauzen test.

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