Prolonged excretion and failure of cross-protection between distinct serotypes of bovine rotavirus

Murakami, Yosuke; Nishioka, Nobuyoshi; Watanabe, T; Kuniyasu, C

doi:10.1016/0378-1135(86)90036-2

Cited by 23 publications

(13 citation statements)

References 25 publications

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“…Serological analyses of calves naturally or experimentally infected with bovine rotaviruses revealed the presence of serotype-specific antibody responses and failure of cross-protection between distinct serotypes [22,23]. On the other hand, the presence of complex antigenic relationships as suggested by one-way heterotypic cross-protection among bovine rotavirus strains have been observed in challenge experiments with strains belonging to two different G types [35,36].…”

Section: Discussionmentioning

confidence: 99%

Presence of three P types (VP4 serotypes) and two G types (VP7 serotypes) among bovine rotavirus strains

Matsuda

Nakagomi

Offit

1990

Archives of Virology

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Cross neutralization tests with a panel of rotavirus strains representing previously described nine VP7 (G) serotypes revealed that bovine rotavirus strain KK-3, a prototype Japanese bovine serotype 2, belonged to a new serotype (G10), confirming and extending the recent report of Snodgrass et al. [J. Clin. Microbiol. 28: 504-507 (1990)] which showed that hyperimmune serum to the KK-3 strain neutralized the B223 strain, a proposed type strain of G10. Further antigenic characteristics of the KK-3 strain, as well as the 0510 strain (a G6 strain isolated in Japan), were examined in terms of their VP4 (P) specificity. For the characterization of P types, we employed genetic reassortants that possess VP4 gene for UK and VP7 gene for D (G1), VP4 gene for NCDV and VP7 gene for SA11 (G3), or VP4 gene for SA11 and VP7 gene for NCDV (G6) in the plaque reduction neutralization assay with hyperimmune sera against these two Japanese strains and the prototype bovine rotavirus NCDV strain. While the 0510 strain had UK-like P and NCDV-like G types, the KK-3 strain had a distinct set of P and G types. Thus, at least three P types (NCDV-, UK-, and KK-3-like) and two G types (G6 and G10) are present among bovine rotavirus strains.

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Section: Discussionmentioning

confidence: 99%

Presence of three P types (VP4 serotypes) and two G types (VP7 serotypes) among bovine rotavirus strains

Matsuda

Nakagomi

Offit

1990

Archives of Virology

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“…Cross-protection between rotaviruses has been studied with isolates from different animal species (Woode et al, 1978;Wyatt et al, 1979;Tzipori et al, 1980;Gaul et al, 1982;Zissis et al, 1983) and between rotaviruses from the same animal species, in calves (Woode et al, 1978(Woode et al, , 1983Murakami et al, 1986) and in pigs (Bohl et aL, 1984). In some of these studies, cross-protection occurred but in others it did not.…”

Section: Discussionmentioning

confidence: 99%

“…Different isolates of bovine rotaviruses differ in their neutralization antigens (Murakami et al, 1983;Woode et al, 1983;Bridger & Brown, 1984) and these differences may be the reason for the lack of cross-protection that has been seen between some bovine rotaviruses (Woode et al, 1978(Woode et al, , 1983Murakami et aL, 1986). Thus, protection after sub-clinical infection with one rotavirus may be restricted to viruses with similar neutralization antigens.…”

Section: Introductionmentioning

confidence: 99%

Avirulent Rotavirus Infections Protect Calves from Disease with and without Inducing High Levels of Neutralizing Antibody

Bridger

Oldham

1987

Journal of General Virology

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SUMMARYTwo bovine rotaviruses, C3-160 and 17/4, which multiplied in calves without inducing disease, were studied for their ability to protect against disease caused by a virulent rotavirus, CP-1. Rotavirus 17/4 and the virulent virus CP-1 cross-neutralized poorly and, on the basis of 20-fold differences in neutralization titres, belonged to different serotypes. Rotaviruses C3-160 and CP-1 were more closely related: neutralization of the CP-1 virus by C3-160 antisera was within 20-fold of the homologous titre although neutralization of the C3-160 virus by CP-1 antisera was not. Nine gnotobiotic calves infected with either C3-160 or 17/4, had rotavirus antibody in their faeces and/or serum 21 days after oral inoculation as detected by indirect immunofluorescence and IgG, IgM and/or IgA antibodies by ELISA. As expected from the antigenic relationships between the viruses, the sera and faeces from the four calves infected with C3-160 contained moderate levels of neutralizing antibody to the virulent virus CP-1 and the sera and most of the faeces from the five calves infected with 17/4 contained undetectable or low levels. When challenged with CP-1 on day 21, four age-matched controls developed disease whereas all of four calves previously infected with C3-160 and four of five calves previously infected with 17/4 were protected from disease. It was concluded that avirulent rotavirus infection provided protection against disease caused by a virulent rotavirus even when one of the avirulent viruses was poorly related to the virulent virus by neutralization. Mechanisms other than neutralizing antibody appeared to be important in protection.

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“…These come primarily from studies on immunity after natural or experimental rotavirus infection of either animals or humans and studies associated with vaccination of humans with live rotaviruses. Some initial experimental infection studies with piglets and calves suggested that neutralizing antibody was critical for protection against disease after subsequent rotavirus challenge [64,65,69], but this was not confirmed in later studies, which, in fact, suggested the opposite [66,67]. Several studies in naturally infected humans also suggest that neutralizing antibody is not the only effector Neonatal rotavirus infections have usually been found to protect against subsequent rotavirus disease even when their serotypes were distinct from the circulating human rotaviruses [3][4][5][6].…”

Section: Evidence That Neutralizing Antibody Is Not An Essential Effementioning

confidence: 99%

Influence of Potential Protective Mechanisms on the Development of Live Rotavirus Vaccines

2010

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Rotaviruses cause extensive morbidity and mortality worldwide, thus corroborating the need for a vaccine that is effective in all socioeconomic environments. Vaccines evaluated in clinical trials have all been live attenuated rotaviruses that are delivered orally to mimic the excellent protection observed after natural infection. The mechanisms by which these vaccine candidates or wild-type rotaviruses elicit protection are not fully understood. During the 1980s, several candidate vaccines provided little protection, particularly in developing countries, and were discontinued. Two, however, are in the process of being licensed worldwide, and several others are undergoing clinical trials. Development of live rotavirus vaccines has been highly influenced by views regarding the importance of serotype-specific neutralizing antibody. Development of several candidate vaccines is based on the concept that neutralizing antibody is the primary determinant of protection. These candidates, including 1 of the 2 being licensed worldwide (RotaTeq), are composed of multiple rotavirus strains representative of the major human rotavirus serotypes. The other group of candidates has been developed based on the theory that protection is not solely dependent on neutralizing antibody. These candidates are composed of single rotavirus strains and include the other vaccine being licensed worldwide (Rotarix). Studies that provide the basis for each approach will be presented and discussed.

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Prolonged excretion and failure of cross-protection between distinct serotypes of bovine rotavirus

Cited by 23 publications

References 25 publications

Presence of three P types (VP4 serotypes) and two G types (VP7 serotypes) among bovine rotavirus strains

Presence of three P types (VP4 serotypes) and two G types (VP7 serotypes) among bovine rotavirus strains

Avirulent Rotavirus Infections Protect Calves from Disease with and without Inducing High Levels of Neutralizing Antibody

Influence of Potential Protective Mechanisms on the Development of Live Rotavirus Vaccines

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