Prolonged ELS test with the marine flatfish sole (Solea solea) shows delayed toxic effects of previous exposure to PCB 126

Foekema, E.M.; Deerenberg, C.M.; Murk, Albertinka J.

doi:10.1016/j.aquatox.2008.08.015

Cited by 53 publications

(31 citation statements)

References 36 publications

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“…teratogenicity, developmental toxicity, hepatotoxicity, im m unotoxicity, progressive w eight loss ('wasting syndrom e') and tum or prom otion (Goldstein and Safe, 1989;Mukerjee, 1998;DeVito and Birnbaum, 1994;Palstra et al, 2006;Foekema et al, 2008). As it has not yet been possible to study physiological changes and toxicological effects in eel during migration, little is known about effects of PCB-exposure on spawning migration of eels.…”

Section: Van Ginneken E T Al / Aquatic Toxicology XXX (2009) Xxx-xxxmentioning

confidence: 99%

“…It has been shown that PCBs and other persistent organic pollutants can be passed on from the m other to their eggs and impair larval sur vival and developm ent (Gutleb et al, 1999(Gutleb et al, , 2007. In sole (Solea solea), the LD50 for larval survival is 1 ng TEQ/g lipid (Foekema et al, 2008), equivalent to 3 pmol TEQ/g lipid. PCB-effects on impaired larval development are not only m ediated by thyroid hormone dis-ruption, but also via disruption of retinoid homeostasis (Brouwer, 1991;Zile, 1992).…”

Section: Possible Consequences Ofpcb-contaminationforeel Reproductionmentioning

confidence: 99%

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PCBs and the energy cost of migration in the European eel (Anguilla anguilla L.)

et al. 2009

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The effect of polychlorinated biphenyls (PCBs) on the energy consum ption of fasting silver European eel (Anguilla anguilla L.) was studied over a 27-day period during w hich the anim als w ere at rest or were sw im m ing 800 km in Blazka sw im tunnels. Three-year-old female hatchery eels (silver stage) betw een 73 and 80 cm long weighing around 1 kg w ere dosed intraperitoneally w ith PCBs at a nom inal dosage of 10x the consum ption standard as a m ixture representative for planar (7 ^gPCB126/kgeel), non-planar (5 m g PCB153/kg eel) and m etabolizable PCBs (50 ^g PCB77/kg eel) found in wild eel, or only w ith the vehicle (corn oil, 10 m l/kg eel). Four m ajor observations were m ade: (1) PCB-exposed anim als lose less w eight com pared to their unexposed controls; (2) PCB-concentrations on a lipid basis are 2.8-14 tim es higher in sw im m ing com pared to resting anim als; (3) the standard m etabolic rate is significantly lower in the PCB-exposed anim als than in unexposed controls. In addition, PCB-exposure significantly reduces oxygen consum ption during swim m ing, and starting at 4 0 0 k m (18 days) this effect increases w ith tim e; (4) the relative spleen and liver w eight significantly increased in the PCB-swim anim als but not in the PCB-rest animals. The sw im m ing anim als lost about 75% m ore w eight com pared to resting anim als and had about 50% lower plasm a fat content. Hematocrit, haem oglobin, plasm a pH, ion levels (sodium and potassium ), and plasm a lactate w ere not affected by PCB-exposure or swim m ing. Apparently, the current levels of PCBs and other dioxin-like com pounds m ay seriously im pair the reproduction of the European eel.

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Section: Van Ginneken E T Al / Aquatic Toxicology XXX (2009) Xxx-xxxmentioning

confidence: 99%

Section: Possible Consequences Ofpcb-contaminationforeel Reproductionmentioning

confidence: 99%

PCBs and the energy cost of migration in the European eel (Anguilla anguilla L.)

et al. 2009

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“…This sensitivity may be due to a large body surface: volume ratio, undifferentiated epithelia, and the vulnerability of the developmental processes (Oberemm 2000). During early ontogenesis critical development of tissues and organs takes place, a process which can easily be disrupted by unfavourable environmental conditions, including exposure to toxic compounds (Foekema et al 2008). For this reason, toxicity tests with ELS of fish are often used to assess the toxic potential of substances and environmental samples.…”

Section: Introductionmentioning

confidence: 99%

A standard ecotoxicological bioassay using early life stages of the marine fishPsetta maxima

Mhadhbi

Boumaïza²,

Beiras

2010

Aquat. Living Resour.

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-Fish tests must be developed for both regulatory and conservation reasons, as such testing forms an indispensable component of integrated toxicity testing strategy for the marine environment. To standardise a fish embryo test, the acute toxicity of metals and polycyclic aromatic hydrocarbons (PAHs) to early life stages (ELS) of turbot (Psetta maxima) was studied. Embryos were exposed to dilutions of cooper, cadmium, mercury, fluoranthene, phenanthrene, pyrene and naphthalene in darkness and under visible light. Hatching success, yolk sac alterations, pericardial edema, skeletal deformities and mortality were observed. The effective concentrations (EC 50 , EC 10 ,) no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC) were determined at the end of the bioassays. Exposure to metals and PAHs in ecologically relevant concentrations, either in darkness or under artificial light, caused significant lethal and sublethal effects in turbot, such as alterations in yolk sac, pericardial edema and skeletal abnormalities. According to the 96 h EC 50 , the ranking of acute toxicity for metals was respectively: 47.4 (46.8-59.2) μg L pyrene, 12.3 (6.4-12.7) μg L −1 fluoranthene, 52.2 (30.4-82.7) μg L −1 phenanthrene, and 142 (55-228) μg L −1 naphthalene. Pyrene was consistently the most toxic PAH. In addition, light exposures were performed and photo-enhanced toxicity was found only for fluoranthene and pyrene. Turbot embryos were found to be more tolerant to metals and PAHs than were hatched larvae. These results suggest that, considering the short duration of the ELS turbot test and its high sensitivity, it is suitable for use as a standard test for marine fish.Key words: PAH / Metal bioavaibility / Acute toxicity / Embryo / Larva / Bioassay / Fish Résumé -Des tests de toxicité doivent être développés sur les poissons en vue de la conservation et la régulation de l'environnement marin. Afin de standardiser un test sur des embryons de poisson, la toxicité de métaux et d'hydrocarbures aromatiques polycycliques sur les premiers stades de développement (ELS) est étudiée chez le turbot (Psetta maxima). Les embryons sont exposés à des solutions de cuivre, cadmium, mercure, fluoranthène, phénanthrène, pyrène et naphthalène en obscurité et à la lumière. Les éclosions, les altérations du sac vitellin, oedèmes du péricarde, déformations du squelette et mortalités sont étudiés. Les concentrations effectives (EC 50 , EC 10 ), ou non (NOEC) et les concentrations minimums provoquant un effet (LOEC) sont déterminées à la fin des essais biologiques. Les expositions aux métaux et hydrocarbures aromatiques en concentrations écologiquement plausibles, soit en obscurité, soit en lumière artificielle, causent des effets létaux et sublétaux significatifs chez le turbot, telles que des altérations du sac vitellin, et des anomalies du squelette. D'après EC 50 (96 h), la toxicité des métaux est la suivante, classée en ordre croissant : 47,4 (46,8-59,2) μg L −1 Cu ; 51,5 (20,9-91,7) μg L −1 Cd, et 83,2 (...

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“…The Ah receptor or dioxin receptor based in vitro assay DR-Luc (also known as DR-CALUX ® (Dioxin Response Chemical Activated LUciferase gene eXpression, a trademark of BDS, Amsterdam, The Netherlands) is considered to be the most useful in vitro bioassay technique for screening for dioxinlike compounds. However the induction of CYP1A/ EROD in fish liver (see OSPAR background document on CYP1A/EROD activity) and chronic in vivo bioassays (Foekema et al, 2008) may also be relevant. An advantage of the application of these in vitro bioassays (using extracts) as compared with CYP1A/EROD is that they are independent of species differences and environmental influences, and so are applicable in a generic way.…”

Section: Introductionmentioning

confidence: 99%

The Distribution of the MusselMytilusSpecies Along the Norwegian Coast

Brooks

Farmen

2013

Journal of Shellfish Research

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Prolonged ELS test with the marine flatfish sole (Solea solea) shows delayed toxic effects of previous exposure to PCB 126

Cited by 53 publications

References 36 publications

PCBs and the energy cost of migration in the European eel (Anguilla anguilla L.)

PCBs and the energy cost of migration in the European eel (Anguilla anguilla L.)

A standard ecotoxicological bioassay using early life stages of the marine fishPsetta maxima

The Distribution of the MusselMytilusSpecies Along the Norwegian Coast

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