Prolonged electrophysiological and behavioral alterations following a single injection of methadone in the cat

Snyder, Edward W.; Shearer, Donald E.; Schlehuber, C; Dustman, Robert E.; Beck, Edward C.

doi:10.1016/0091-3057(80)90450-5

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…A metadona é um opioide sintético, que apresenta efeitos farmacológicos semelhantes à morfina, sendo um agonista dos receptores opioides mi (µ), delta (δ) e kappa (κ) que, paralelamente, atua como antagonista dos receptores N-metil D-aspartato (NMDA), o que contribui para incrementar a analgesia promovida por este fármaco, principalmente no tratamento de dor crônicas e neuropática (Bley et al, 2004;Snyder et al, 1980). Apresenta vantajosas características que incluem período de ação prolongado e potência analgésica alta, sem a formação de metabólitos ativos (Lamont & Mathews, 2007).…”

Section: Introductionunclassified

Evaluación analgésica de la metadona, en dos dosis asociadas a la lidocaína sin vasoconstrictor, por vía epidural en perros sometidos a castración electiva

Antunes¹,

Vidis²,

Bairros³

2020

Pubvet

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Diversos fármacos podem ser empregados no controle da dor, por diversas vias, como a epidural. A metadona é um opioide sintético semelhante a morfina, podendo ser utilizado pela via epidural para controle da dor, principalmente durante procedimentos cirúrgicos como a orquiectomia. Foram selecionados nove cães machos para realização do estudo de ação analgésica da metadona por via epidural em duas concentrações, 0,1mg/kg (M01) e 0,3 mg/kg (M03), associadas a lidocaína sem vasoconstritor, o grupo controle recebeu apensas lidocaína (LID) por via epidural. Para avalia os grupos foram mesurados e analisados estatisticamente os valores de frequência cardíaca, frequência respiratória, saturação de oxigênio, temperatura e pressão arterial sistólica. Os grupos M01 e M03 não divergiram entre si estatisticamente, o grupo LID apresentou medias diferentes dos grupos M01 e M03 para os valores de frequência cardíaca e respiratória, saturação de oxigênio e pressão arterial diastólica, confirmando a necessidade da utilização de fármacos analgésicos em procedimentos cirúrgicos, principalmente nos momentos de maior estimulação nociceptiva.

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Section: Introductionunclassified

Evaluación analgésica de la metadona, en dos dosis asociadas a la lidocaína sin vasoconstrictor, por vía epidural en perros sometidos a castración electiva

Antunes¹,

Vidis²,

Bairros³

2020

Pubvet

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EEG frequency patterns in the cat prepyriform cortex during sleep and waking

Willey

Adey

Maeda

et al. 1985

Neurological Research

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Mapping, in the rat central nervous system, of morphine‐induced changes in turnover of 5‐hydroxytryptamine.

Snelgar¹,

Vogt²

1981

The Journal of Physiology

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SUMMARY1. It is known that the full clinical effect of morphine is not seen if those neurones of the central nervous system which contain 5-hydroxytryptamine (5-HT) have been inactivated. Morphine increases 5-HT turnover in brain and cord, and the present work is an attempt at mapping the sites at which turnover is accelerated.2. The degree of interaction at various sites of the C.N.S. was measured by the increment in the content of 5-hydroxyindol-3-yl acetic acid (5-HIAA) elicited by morphine in rats pre-treated with probenecid. The effect was produced by as little as 3-5 mg morphine hydrochloride/kg; for the sake of convenience this dose was doubled in most experiments. Pre-treatment with probenecid was not necessary for the effect, but a minimum interval of 90 min between injection of morphine and analysis of the brain was essential.3. Morphine did not act indiscriminately on all 5-HT neurones, as seen by the fact that the increment in 5-HIAA formation was independent of the density of 5-HT neurones in the tissue. Nor was there any relation between basal 5-HT turnover of a region and the size of its response to morphine.4. Highly reactive sites were found in dorsal cord, medulla, superior colliculi, substantia nigra, thalamus, hypothalamus, amygdala and striatum. Cortical areas were less responsive, but with large differences among themselves. Hippocampus, central grey, olfactory bulb, cerebellum and white matter had lower or negligible increases in 5-HT turnover. There was no increase in the turnover of the (non-neural) 5-HT of the pineal gland.5. The relation of the reactive sites to their content in endogenous opioids and to the probable localization of the pharmacological actions of morphine is discussed.

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Prolonged electrophysiological and behavioral alterations following a single injection of methadone in the cat

Cited by 3 publications

References 16 publications

Evaluación analgésica de la metadona, en dos dosis asociadas a la lidocaína sin vasoconstrictor, por vía epidural en perros sometidos a castración electiva

Evaluación analgésica de la metadona, en dos dosis asociadas a la lidocaína sin vasoconstrictor, por vía epidural en perros sometidos a castración electiva

EEG frequency patterns in the cat prepyriform cortex during sleep and waking

Mapping, in the rat central nervous system, of morphine‐induced changes in turnover of 5‐hydroxytryptamine.

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