Prolonged drug release properties for orodispersible films by combining hot-melt extrusion and solvent casting methods

Speer, Isabell; Preis, Maren; Breitkreutz, Jörg

doi:10.1016/j.ejpb.2018.05.023

Cited by 50 publications

(31 citation statements)

References 23 publications

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“…Even though rapid disintegrating is the main feature of ODFs, in particular cases prolonged drug release from ODFs would also be beneficial, especially for patients with swallowing deficiencies. Prolonged drug release from ODFs has been achieved by incorporating drug-loaded matrix particles based on Eudragit® RS and silicon dioxide [92]. In that study, the matrix particles, with theophylline as a model drug, were produced by hot melt extrusion (HME), and the ODFs were subsequently produced by the solvent casting method.…”

Section: Prolonged Drug Releasementioning

confidence: 99%

Oromucosal films: from patient centricity to production by printing techniques

Tian

Orlu

Woerdenbag

et al. 2019

Expert Opinion on Drug Delivery

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Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.

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Section: Prolonged Drug Releasementioning

confidence: 99%

Oromucosal films: from patient centricity to production by printing techniques

Tian

Orlu

Woerdenbag

et al. 2019

Expert Opinion on Drug Delivery

Self Cite

View full text Add to dashboard Cite

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“…The other possibility is to suspend the drug in the aqueous solution of the polymer used for casting the film, which allows uncontrolled recrystallization to be avoided [8,16,17,[19][20][21][22][23][24]. However, the formulation of such biphasic films, containing suspended API, implies serious challenges regarding the uniformity of the content, texture, and appropriate mechanical properties of the films [15].…”

Section: Introductionmentioning

confidence: 99%

Technology of Orodispersible Polymer Films with Micronized Loratadine—Influence of Different Drug Loadings on Film Properties

2020

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The production of orodispersible films (ODFs) with suspended insoluble drug substances is still a challenge, mainly due to the difficulty associated with achieving a proper homogeneity and mechanical properties of the films. Hypromellose (HPMC) and a mixture of polyvinyl alcohol (AP) and povidone (PVP) were compared in terms of their suitability for ODFs incorporating suspended micronized loratadine (LO) in a concentration range of 10%–40%. In a planetary mixer (Thinky), a uniform dispersion of LO in an aqueous viscous casting solution was obtained. The suspended LO particles caused dose-dependent changes in the viscosity of the casting mass and affected the mechanical quality of ODFs. Drug concentrations higher than 30% reduced the film flexibility and tear resistance, depending on the polymer type. LO films with a thickness of 100 µm disintegrated within 60-100 s, with no significant influence of the LO content in the range 10%–30%. HPMC films, regardless of the drug concentration, met the pharmacopoeial requirements regarding the uniformity of the drug content. AP/PVP films were too elastic, and the drug content uniformity was not achieved. The conclusion is that, using an HPMC matrix, it is possible to obtain a high load of a poorly water-soluble drug (30% of dry film mass corresponds to a dose of 5 mg per 1.5 cm2) in ODFs characterized by proper physical characteristics.

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“…Other administration formulations can be explored, including a single dose, long-acting injectable, a trans-mucosal gel that children can put under their tongue, or oral nano-suspensions that would be taken up by mucosal cells for slow release. Gummies with delayed release formulations or transdermal patches are also possible delivery systems [67][68][69][70][71][72]. Although not established, we speculate that the ideal dosing target would be once a month, with a maximum frequency of once in every one to two weeks [15].…”

Section: Slow Release Formulation Of Bkis To Achieve Steady State Thementioning

confidence: 93%

Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission

et al. 2020

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Transmission of human malaria parasites (Plasmodium spp.) by Anopheles mosquitoes is a continuous process that presents a formidable challenge for effective control of the disease. Infectious gametocytes continue to circulate in humans for up to four weeks after antimalarial drug treatment, permitting prolonged transmission to mosquitoes even after clinical cure. Almost all reported malaria cases are transmitted to humans by mosquitoes, and therefore decreasing the rate of Plasmodium transmission from humans to mosquitoes with novel transmission-blocking remedies would be an important complement to other interventions in reducing malaria incidence.

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Prolonged drug release properties for orodispersible films by combining hot-melt extrusion and solvent casting methods

Cited by 50 publications

References 23 publications

Oromucosal films: from patient centricity to production by printing techniques

Oromucosal films: from patient centricity to production by printing techniques

Technology of Orodispersible Polymer Films with Micronized Loratadine—Influence of Different Drug Loadings on Film Properties

Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission

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