Prolonged Detection of Human Bocavirus Dna in Nasopharyngeal Aspirates of Children With Respiratory Tract Disease

Blessing, Kerstin; Neske, Florian; Herre, Ulla; Kreth, Hans-Wolfgang; Weißbrich, Benedikt

doi:10.1097/inf.0b013e3181a854ae

Cited by 62 publications

(60 citation statements)

References 9 publications

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“…This might be explained by deficient immune responses in the studied children with wheezing and RV infection (6, 7, 44 The second most common pathogen in asymptomatic infections was HBoV. This is consistent with earlier studies when HBoV has been found in up to 44% of asymptomatic infections with prolonged presence in immunocompetent children and suggests that many asymptomatic HBoV infections are truly asymptomatic (37, 38). Moreover, MPV, EV and CV showed similar prevalence in asymptomatic and symptomatic infections (Online Supplementary, Table S1).…”

Section: Discussionsupporting

confidence: 83%

Clinical and Virus Surveillance After the First Wheezing Episode

Turunen

Vuorinen

Bochkov

et al. 2017

Pediatric Infectious Disease Journal

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Background Susceptibility to rhinovirus (RV) induced early wheezing episode has been recognized as an important risk factor for asthma but the data on different RV species is limited. Our aim was to investigate the risk for recurrences in first-time wheezing children with special focus on RV species. Methods First-time wheezing children (88/23 in-/outpatients) were prospectively followed at 2-week, 2-month and 12-month time-points, and at first recurrence within 12 months. The respiratory virus etiology was analyzed using PCR. RV positive samples were sequenced. The primary outcomes were time to a new physician-confirmed wheezing episode and time to the initiation of regular controller medication for asthma symptoms. Results The median age of the children was 12 months (SD 6.0), 67% were males and 23% were sensitized. RV dominated in symptomatic and asymptomatic infections. Different virus strains caused 97 % of the consecutive RV infections. First-time wheezing children with RV-C (respectively 3.6; p < 0.001) and RV-A (hazard ratio 3.6, p = 0.002) had an increased risk for a new wheezing episode than non-RV group. Also, the risk for the initiation of regular controller medication was increased in RV-A and RV-C groups (both p < 0.05), respectively. There was no difference in response on oral prednisolone between RV-A and RV-C. Conclusions RV causes reinfections with different strains in small children after the first wheezing episode. Both RV-A and RV-C affected children have an increased risk for recurrence and initiation of regular controller medication than those with other viruses.

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Section: Discussionsupporting

confidence: 83%

Clinical and Virus Surveillance After the First Wheezing Episode

Turunen

Vuorinen

Bochkov

et al. 2017

Pediatric Infectious Disease Journal

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“…[26][27][28][29] However, no evidence of systemic, genuinely long-term (years; decades) persistence exists for HBoV, 30,31 as exists for the other parvovirusesfor B19 in multiple organs [30][31][32] and for parvovirus 4 in lymphoid tissues. 30,[33][34][35] Neither have any data (molecular or serological) been presented to indicate that HBoV secondary infectionsendogenous reactivations or exogenous reinfections -do occur.…”

Section: Discussionmentioning

confidence: 94%

Dating of human bocavirus infection with protein-denaturing IgG-avidity assays—Secondary immune activations are ubiquitous in immunocompetent adults

Hedman

Söderlund‐Venermo

Jartti

et al. 2010

Journal of Clinical Virology

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“…HBoV1 DNA may reside in the upper airways for months after acute infection, either due to getting trapped in the nasopharynx, prolonged shedding or mucosal contamination from virus particles in the breathing air [34–37]. Similar tissue persistence as that of B19 virus or AAV, has, however, not been detected for HBoV, at least to the same extent [31,38–40].…”

Section: Clinical Impact and Epidemiologymentioning

confidence: 99%

Genomic Features of the Human Bocaviruses

Schildgen¹,

Qiu

Söderlund‐Venermo

2011

Future Virol.

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The human bocavirus (HBoV) was initially discovered in 2005 as the second pathogenic member of the parvovirus family, next to the human parvovirus B19. HBoV has since been shown to be extremely common worldwide and to cause a systemic infection in small children often resulting in respiratory disease. Three more, presumably enteric, human bocaviruses (HBoV2–4) have been identified in stool samples. Parvoviruses are assumed to replicate via their genomic terminal hairpin-like structures in a so-called ‘rolling-hairpin model’. These terminal sequences have recently been partially identified in head-to-tail HBoV-PCR amplicons from clinical samples, and are most likely hybrid relics of HBoV’s predecessors, namely bovine parvovirus 1 on the left-hand side and minute virus of canines on the right, shown for the first time in this article. Thereby, the replication model postulated for HBoV remains questionable as the occurrence of head-to-tail sequences is not a typical feature of the rolling-hairpin replication model. However, such episomes can also be persistent storage forms of the genome.

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Prolonged Detection of Human Bocavirus Dna in Nasopharyngeal Aspirates of Children With Respiratory Tract Disease

Cited by 62 publications

References 9 publications

Clinical and Virus Surveillance After the First Wheezing Episode

Clinical and Virus Surveillance After the First Wheezing Episode

Dating of human bocavirus infection with protein-denaturing IgG-avidity assays—Secondary immune activations are ubiquitous in immunocompetent adults

Genomic Features of the Human Bocaviruses

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