Journal of Cell Biology volume 217, issue 7, P2429-2443 2018 DOI: 10.1083/jcb.201708153 View full text
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Gabriel M. Gihana, Tiffany R. Musser, Oscar Thompson, Soni Lacefield

Abstract: We investigated how coordinate polarization, budding, and anaphase during a unique developmental program called return to growth (RTG) in which cells in meiosis return to mitosis upon nutrient shift. Cells reentering mitosis from prophase I deviate from the normal cell cycle by budding in G2 instead of G1. We found that cells do not maintain the bipolar budding pattern, a characteristic of diploid cells. Furthermore, strict temporal regulation of M-phase cyclin-dependent kinase (CDK; M-CDK) is important for po…

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