Prolonged corrected QT dispersion

Orditura, Michele; Sarubbi, Berardo; DeVita, F.; Ducceschi,; Santangelo, L; Cariello, Alberto; Iacono, A; Catalano, Giuseppe

doi:10.3892/or.4.5.1047

Cited by 2 publications

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“…However, patients with poor blood collecting flow might be exhibited with prolongation of QTbcD during evaluation before leukocyte apheresis. Reports show that QTc and QTD are prolonged in patients with neoplasms [35,36]. QT prolongation can be caused by cancer therapies, electrolyte disturbances, predisposing factors, and concomitant medications (e.g., anti-emetics, cardiac medications, antibiotics, and psychoactive drugs) [31,37].…”

Section: Discussionmentioning

confidence: 99%

Predictive factors of poor blood collecting flow during leukocyte apheresis for cellular therapy

et al. 2021

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Leukocyte apheresis is necessary in various cellular therapies. However, maintenance of a stable flow rate during leukocyte apheresis is often difficult, even in patients or donors without major problems. Despite this, predictive methods and evidence regarding the reality of the situation are limited. We conducted a retrospective analysis involving adult patients who required leukocyte apheresis for the treatment of neoplasms using WT1-pulsed dendritic cell vaccine.Monocytes were separated from apheresis products to obtain dendritic cells. All the patients were pre-evaluated based on laboratory and chest X-ray findings and subjected to an identical apheresis procedure. The occurrence of poor blood collecting flow during leukocyte apheresis was monitored, and the frequency, clinical information, and associated risk factors were analyzed. Among 160 cases, poor blood collecting flow was observed in 53 cases (33.1%) in a median time of 54 min (range, 2-127 min) post-initiation of leukocyte apheresis. Owing to difficulty in obtaining higher collecting flow, a longer procedure time was required, and in some cases, the scheduled apheresis cycles could not be completed. Consequently, the number of harvested monocytes was low. Multivariable analysis indicated that female patients have an increased risk of poor inlet flow rate. Furthermore, prolonged QT dispersion (QTD) calculated using Bazett's formula was found to be a risk factor. Although the patients did not present any major problems during leukocyte apheresis, poor blood collecting flow was observed in some cases. Sex and pre-evaluated QTD might be useful predictors for these cases; however, further prospective evaluation is necessary.

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Section: Discussionmentioning

confidence: 99%

Predictive factors of poor blood collecting flow during leukocyte apheresis for cellular therapy

et al. 2021

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“…First reports on anthracycline-induced QTd prolongation were submitted over 20 years ago [ 19 ]. Cylcophosphamid therapy also prolonged QTd, and prolonged QTd predicted the occurrence of acute heart failure [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

ECG Changes in Melanoma Patients Undergoing Cancer Therapy—Data from the ECoR Registry

Pohl

Mincu

Mrotzek

et al. 2020

JCM

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We aimed to evaluate whether therapy with immune checkpoint inhibitors (ICI) leads to changes in electrocardiogram (ECG) parameters in melanoma patients. We retrospectively examined 41 patients (46% women, age 61 ± 12years) with advanced melanoma (stage III/IV) before and during ICI treatment from our “Essen Cardio-oncology Registry” (ECoR). ECGs were analyzed before and 4–12 weeks after therapy started (follow-up, 90 ± 51 days). Heart rate, PR time, QRS duration and duration of the corrected QT (QTc) interval were recorded. QT dispersion (QTd) was calculated. Heart rate, PR time, QRS and QTc did not differ when comparing values before and after therapy started. QTd was prolonged after therapy started (32 ± 16 ms vs. 47 ± 19 ms, n = 41, p < 0.0001). Subgroup analyses revealed prolonged QTd in patients that received a combination immunotherapy with ipilimumab and nivolumab (31 ± 14 ms vs. 50 ± 14 ms, n = 21, p < 0.0001), while QTd in patients with anti–programmed death 1 (PD-1) inhibitor monotherapy did not change after therapy started. QTd is prolonged in patients under ICI combination therapy, potentially signaling an increased susceptibility to ventricular arrhythmias.

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Prolonged corrected QT dispersion

Cited by 2 publications

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Predictive factors of poor blood collecting flow during leukocyte apheresis for cellular therapy

Predictive factors of poor blood collecting flow during leukocyte apheresis for cellular therapy

ECG Changes in Melanoma Patients Undergoing Cancer Therapy—Data from the ECoR Registry

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