Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline

Spiller, Henry A.; Griffith, Jill R. K.

doi:10.1080/15563650701258070

Cited by 12 publications

(14 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sinoatrial node block lasting up to 20 h has been also reported [20]. A prolonged cardiovascular effect up to 36 h was reported after ingestion of THZ [45].…”

Section: What Is the Expected Onset And Duration Of Imidazoline Toxicmentioning

confidence: 83%

Unintentional Pediatric Ophthalmic Tetrahydrozoline Ingestion: Case Files of the Medical Toxicology Fellowship at the University of California, San Francisco

2014

View full text Add to dashboard Cite

An 18-month-old child was brought to the emergency department (ED) by his mother for evaluation of diarrhea, vomiting, and somnolence. He was lethargic, with "pinpoint" pupils. Blood pressure was 125/77 mmHg, heart rate was 70/min, temperature was 36.5°C, respiratory rate was 25/min, and pulse oximetry saturation (SpO 2 ) was 99 % on room air. Blood glucose was 101 mg/dL. Other initial laboratory investigation was unremarkable. Ethanol, acetaminophen, and aspirin were below detection limits. Urine drug screening was negative for amphetamine, methamphetamine, MDMA, barbiturates, benzodiazepines, cocaine, methadone, oxycodone, and opiates. Initial ECG done 3 h after ED arrival showed bradycardia with first-degree heart block. There was no response to 1 mg IV naloxone.

show abstract

“…Sinoatrial node block lasting up to 20 h has been also reported [20]. A prolonged cardiovascular effect up to 36 h was reported after ingestion of THZ [45].…”

Section: What Is the Expected Onset And Duration Of Imidazoline Toxicmentioning

confidence: 83%

Unintentional Pediatric Ophthalmic Tetrahydrozoline Ingestion: Case Files of the Medical Toxicology Fellowship at the University of California, San Francisco

2014

View full text Add to dashboard Cite

show abstract

“…But both samples were obtained >16–22 h postexposure, suggesting urine may be a better sample in late presentations of tetrahydrozoline exposure. In contrast, the published reports of tetrahydrozoline ingestion have consistently noted duration of clinical effects of 8–24 h postingestion (12–17). The half‐life of tetrahydrozoline and detection in blood may not match its duration of clinical effects.…”

Section: Discussionmentioning

confidence: 97%

“…However, after ingestion, tetrahydrozoline readily crosses the blood-brain barrier and produces presynaptic alpha-2 stimulation (21). Clinical effects from central alpha-2 receptor agonism from tetrahydrozoline are similar to other imidazoline derivatives such as clonidine, tizanadine, and naphazoline (12)(13)(14)(15)(16)22). Reported effects include drowsiness, coma, respiratory depression, bradycardia, hypotension, hypotonia, muscle flaccidity, and hypothermia (12)(13)(14)(15)(16)22).…”

Section: Discussionmentioning

confidence: 99%

“…A bottle of an over-the-counter ''eye drops'' (e.g., Visine Ò ; Johnson & Johnson, SKillman, NJ) may not raise suspicions of a potential victim or police investigators (6). It is a potent CNS depressant with a rapid onset (13). Use of tetrahydrozoline would produce a flaccid, obtunded, or comatose victim, potentially unable to resist an attacker.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Drug‐Facilitated Sexual Assault Using Tetrahydrozoline

Spiller

Siewert

2011

Journal of Forensic Sciences

View full text Add to dashboard Cite

Drug-facilitated sexual assault (DFSA) has been defined as the use of a chemical agent to facilitate a sexual assault. We report two cases of the use of tetrahydrozoline for DFSA. We believe this is the first report with urinary quantification of tetrahydrozoline levels postassault. Blood and urine were obtained c. 20 h postexposure in two cases of reported DFSA. Tetrahydrozoline was not detected in blood but was identified in urine in both victims. After initial identification in the urine using the 2010 update to the AAFS mass spectrometry database library, tetrahydrozoline was quantified at 114 and 150 ng/mL, respectively, using GC/MS. Two unique clinical features reported in these cases were intermittent periods of consciousness and postexposure vomiting. Use of GC/MS was successful in identifying tetrahydrozoline in the 100 ng/mL range up to 20 h postexposure. For victims with late presentation, urine may be a better sample for evaluation for tetrahydrozoline.

show abstract

“…1 Although most of them are benign, it is important their classification, because sometimes could be produce it by a herald a vision-threatening or even lifethreatening disorders. [1][2][3][4] There are drops which contain sympathomimetic amines (as example: thetraydrozoline, nafazoline or oxymetazoline), drugs which produce conjunctival vessels vasoconstriction. But whiten the eyes could hide a problem and delay the possibility to establish the correct diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Red eyes first sign of the sickle cell disease

Torres¹,

Lódolo²

2011

Optometry Rep

View full text Add to dashboard Cite

A patient with red eyes and ocular decongestants drops (tetrahidrozolyne 0.05%) use history, was observed by an optometrist and referred to an ophthalmic consult. The redness of their eyes was secondary to conjunctival vessel micro-hemorraghe (petechiaes). After a complete ophthalmology and hematologist exploration a Cell Sickle Disease was diagnosed as the cause of the vascular disorder. An hematologist treat it and the ocular redness was resolved. This case emphasizes the problem about self-medication and remark the importance of the optometrist working together with the ophthalmologist to prevent ocular complains as well as systemic disease.

show abstract

Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline

Cited by 12 publications

References 11 publications

Unintentional Pediatric Ophthalmic Tetrahydrozoline Ingestion: Case Files of the Medical Toxicology Fellowship at the University of California, San Francisco

Unintentional Pediatric Ophthalmic Tetrahydrozoline Ingestion: Case Files of the Medical Toxicology Fellowship at the University of California, San Francisco

Drug‐Facilitated Sexual Assault Using Tetrahydrozoline

Red eyes first sign of the sickle cell disease

Contact Info

Product

Resources

About