1997
DOI: 10.1055/s-2007-994126
|View full text |Cite
|
Sign up to set email alerts
|

Prolonged Apnea in the Preterm Infant is Not A Random Event

Abstract: We tested the hypothesis that in preterm infants, prolonged apneas (apneas > or = 20 sec) are not random events but are preceded by frequent and progressively longer respiratory pauses associated with changes in ventilatory variables. We studied 36 preterm infants with apnea [birth weight 1190 +/- 60 g (mean +/- SEM), study weight 1300 +/- 60 g, gestational age 28 +/- 1 weeks, and postnatal age 23 +/- 2 days]. A nosepiece with a flow-through system was used to measure ventilation and alveolar gases. Throughout… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

2005
2005
2019
2019

Publication Types

Select...
4
3

Relationship

0
7

Authors

Journals

citations
Cited by 15 publications
(4 citation statements)
references
References 9 publications
0
4
0
Order By: Relevance
“…The original design of the protocol is supported by clinical observations that repeated exposure to hypoxia occur frequently during episodes of sleep apnea (Lavie et al, ; Charboneau et al, 1994; Cala et al, ; Monserrat et al, 1996) and that autoresuscitation can fail following repeated apneic episodes in infants that suffer from SIDS (Stevens, ; Poets et al, , Sridhar et al, ). We slightly modified the protocol by progressively increasing the duration of the hypoxic challenges based on the observation that repeated periods of hypoxia, often of increasing duration, are observed in preterm infants (Daily et al, ; Steinschneider, ; Rigatto and Brady, ,b; Al‐Saedi et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…The original design of the protocol is supported by clinical observations that repeated exposure to hypoxia occur frequently during episodes of sleep apnea (Lavie et al, ; Charboneau et al, 1994; Cala et al, ; Monserrat et al, 1996) and that autoresuscitation can fail following repeated apneic episodes in infants that suffer from SIDS (Stevens, ; Poets et al, , Sridhar et al, ). We slightly modified the protocol by progressively increasing the duration of the hypoxic challenges based on the observation that repeated periods of hypoxia, often of increasing duration, are observed in preterm infants (Daily et al, ; Steinschneider, ; Rigatto and Brady, ,b; Al‐Saedi et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…Apnoeas in preterm infants can be profound due to their low respiratory reserve capacity coupled with their high metabolic demands, apnoeas induce temporary bradycardia and loss of reflex neural drive from the lung (Fyfe, Yiallourou, Wong, & Horne, ; Gerhardt & Bancalari, ). Apnoeas are commonly preceded by periods of hypoventilation (Adams, Zabaleta, & Sackner, ; Al‐Saedi et al., ; Poets & Southall, ). Although the carotid body is likely to be anatomically mature at birth (Hervonen & Korkala, ), it takes time for the preterm to establish hypoxic and CO 2 thresholds after birth, which usually occurs over a period of hours to days of life (Darnall, ; Williams et al., ), but this may be delayed in infants with recurrent apnoea (Katz‐Salamon, ).…”
Section: Preterm Physiologymentioning
confidence: 99%
“…24 Prolonged apnea episodes are not random events; they often follow periods of disturbed respiratory control and are characterized by significant drops in oxygen saturation, decreased minute ventilation and respiratory rate, and increased frequency of shorter apnea episodes. 25 Infants with prolonged apneas also have increased periodic breathing. 25 Pure central apnea results from depressed bulbopontine respiratory center output, as evidenced by the complete lack of respiratory muscle activity.…”
Section: Pathophysiology Of Apneamentioning
confidence: 99%
“…25 Infants with prolonged apneas also have increased periodic breathing. 25 Pure central apnea results from depressed bulbopontine respiratory center output, as evidenced by the complete lack of respiratory muscle activity. 4 Central apnea can be induced by the preterm infant's "normal" physiological responses to hypoxia, hypercapnia, or acidosis.…”
Section: Pathophysiology Of Apneamentioning
confidence: 99%