Prolonged analgesic effect of PLGA-encapsulated bee venom on formalin-induced pain in rats

Jeong, Injae; Kim, Beom Soo; Lee, Hyejung; Lee, Kang-Min; Shim, Insop; Kang, Sung-Keel; Yin, Chang-Shick; Hahm, Dae‐Hyun

doi:10.1016/j.ijpharm.2009.06.034

Cited by 26 publications

(16 citation statements)

References 21 publications

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“…All the nanoparticles preparation exhibited negative zeta potential values. A more negative zeta potential of the nanoparticles suggested more dispersion stability of the nanoparticles in the medium (Jeong et al, 2009). Thus, the PHA-mPEG nanoparticles form a stable colloidal suspension in aqueous medium.…”

Section: Preparation and Characterization Of Nanoparticlesmentioning

confidence: 95%

Amphiphilic PHA–mPEG copolymeric nanocontainers for drug delivery: Preparation, characterization and in vitro evaluation

Shah

Naseer

Choi

et al. 2010

International Journal of Pharmaceutics

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Section: Preparation and Characterization Of Nanoparticlesmentioning

confidence: 95%

Amphiphilic PHA–mPEG copolymeric nanocontainers for drug delivery: Preparation, characterization and in vitro evaluation

Shah

Naseer

Choi

et al. 2010

International Journal of Pharmaceutics

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“…In a neuropathic pain model of chronic constriction injury (CCI) induced by tight ligatures of the sciatic nerve, thermal hyperalgesia was reduced 5–45 min, but not 60 min, after a single bee venom injection in the Zusanli acupoint (Roh et al, 2004). Antinociception has been reported in the formalin test initiated up to 2 h after bee venom injection, and up to 12 h after acupoint injection of poly (lactic-co-glycolic acid) nanoparticle-encapsulated bee venom (Jeong et al, 2009). Currently, it is not known how the transient antinociceptive effect of bee venom injection is related to a more prolonged (and anti-inflammatory) effect.…”

Section: Anti-nociceptive and Anti-inflammatory Effects Of Bvtmentioning

confidence: 99%

The nociceptive and anti-nociceptive effects of bee venom injection and therapy: A double-edged sword

Chen

Lariviere

2010

Progress in Neurobiology

159

121

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Bee venom injection as a therapy, like many other complementary and alternative medicine approaches, has been used for thousands of years to attempt to alleviate a range of diseases including arthritis. More recently, additional theraupeutic goals have been added to the list of diseases making this a critical time to evaluate the evidence for the beneficial and adverse effects of bee venom injection. Although reports of pain reduction (analgesic and antinociceptive) and anti-inflammatory effects of bee venom injection are accumulating in the literature, it is common knowledge that bee venom stings are painful and produce inflammation. In addition, a significant number of studies have been performed in the past decade highlighting that injection of bee venom and components of bee venom produce significant signs of pain or nociception, inflammation and many effects at multiple levels of immediate, acute and prolonged pain processes. This report reviews the extensive new data regarding the deleterious effects of bee venom injection in people and animals, our current understanding of the responsible underlying mechanisms and critical venom components, and provides a critical evaluation of reports of the beneficial effects of bee venom injection in people and animals and the proposed underlying mechanisms. Although further studies are required to make firm conclusions, therapeutic bee venom injection may be beneficial for some patients, but may also be harmful. This report highlights key patterns of results, critical shortcomings, and essential areas requiring further study.

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“…The nanoencapsulation advantages include a more strict contact with the stratum corneum, due to a great skin adhesion of the nanostructures (8) and a controlled release of the active substances (9). Those advantages lead to a more prolonged action (10,11) and increase in efficacy (12). Due to the size of around 300 nm, those nanoparticles used on the skin are not able to cross the intact stratum corneum (7).…”

Section: Introductionmentioning

confidence: 99%

Nanoencapsulation of Rose-Hip Oil Prevents Oil Oxidation and Allows Obtainment of Gel and Film Topical Formulations

et al. 2015

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Abstract. The rose-hip oil holds skin regenerating properties with applications in the dermatological and cosmetic area. Its nanoencapsulation might favor the oil stability and its incorporation into hydrophilic formulations, besides increasing the contact with the skin and prolonging its effect. The aim of the present investigation was to develop suitable rose-hip-oil-loaded nanocapsules, to verify the nanocapsule effect on the UV-induced oxidation of the oil and to obtain topical formulations by the incorporation of the nanocapsules into chitosan gel and film. The rose-hip oil (500 or 600 μL), polymer (Eudragit RS100®, 100 or 200 mg), and acetone (50 or 100 mL) contents were separately varied aiming to obtain an adequate size distribution. The results led to a combination of the factors acetone and oil. The developed formulation showed average diameter of 158±6 nm with low polydispersity, pH of 5.8±0.9, zeta potential of +9.8 ±1.5 mV, rose-hip oil content of 54±1 μL/mL and tendency to reversible creaming. No differences were observed in the nanocapsules properties after storage. The nanoencapsulation of rose-hip oil decreased the UVA and UVC oxidation of the oil. The chitosan gel and film containing rose-hip-oil-loaded nanocapsules showed suitable properties for cutaneous use. In conclusion, it was possible to successfully obtain rose-hip-oil-loaded nanocapsules and to confirm the nanocapsules effect in protecting the oil from the UV rays. The chitosan gel and film were considered interesting alternatives for incorporating the nanoencapsulated rose-hip oil, combining the advantages of the nanoparticles to the advantages of chitosan.

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Prolonged analgesic effect of PLGA-encapsulated bee venom on formalin-induced pain in rats

Cited by 26 publications

References 21 publications

Amphiphilic PHA–mPEG copolymeric nanocontainers for drug delivery: Preparation, characterization and in vitro evaluation

Amphiphilic PHA–mPEG copolymeric nanocontainers for drug delivery: Preparation, characterization and in vitro evaluation

The nociceptive and anti-nociceptive effects of bee venom injection and therapy: A double-edged sword

Nanoencapsulation of Rose-Hip Oil Prevents Oil Oxidation and Allows Obtainment of Gel and Film Topical Formulations

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