Prolongation of the heart rate-corrected QT interval is associated with cardiovascular diseases: Systematic review and meta-analysis

Welten, Sabrina J.G.C.; Elders, Petra J. M.; Remmelzwaal, Sharon; Doekhie, Roos; Kee, Kok Wai; Nijpels, Giel; Heijden, Amber A. van der

doi:10.1016/j.acvd.2022.11.007

Cited by 4 publications

(2 citation statements)

References 69 publications

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“…Certain heart conditions, such as cardiomyopathy, heart failure, and myocardial infarction, may be associated with QT prolongation. Welten SJGC et al 3 prolongation of the heart rate-corrected QT interval (QTc) on electrocardiogram (ECG) has been extensively studied as a risk factor for CVD and CVD mortality. The increased risk of CVD caused by prolonged QTc interval may increase susceptibility to ventricular fibrillation and sudden death.…”

Section: Heart Diseasesmentioning

confidence: 99%

Electrocardiographic change: prolongation of the QT interval, imminent risk of sudden death

Oliveira de Souza

2024

JCCR

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Section: Heart Diseasesmentioning

confidence: 99%

Electrocardiographic change: prolongation of the QT interval, imminent risk of sudden death

Oliveira de Souza

2024

JCCR

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“…Acquired QTc prolongation also occurs at higher rates in patients with advancing CKD than in the general population. It is predicted by pathologic LVH, atrial fibrillation, coronary artery disease, diabetes, heart failure, electrolyte disturbances, use of QT prolonging medications, and hemodialysis-related fluxes in electrolyte concentrations [5‒8]. However, while it predicts overall and sudden death in patients with dialysis-dependent CKD, the associations and mortality impact of QTc prolongation in patients with predialysis CKD (who significantly outnumber those that require dialysis) remain understudied [5‒7].…”

Section: Introductionmentioning

confidence: 99%

QTc interval prolongation independently associates with FGF23 and predicts mortality in predialysis CKD.

Sikaneta,

Ho,

Bellasi

et al. 2024

Cardiorenal Med

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Introduction: QTc interval prolongation is increasingly frequent as CKD advances and predicts death in dialysis. However, predictors and mortality-risk in predialysis CKD are understudied. FGF23 induces left ventricular hypertrophy (LVH) which is associated with QTc interval prolongation and death, suggesting a possible pathway from FGF23 to death that entails LVH and QTc prolongation. We looked for links between FGF23 and prolonged QTc intervals mediated by LVH, and for deaths associated with QTc prolongation in a prospective observational cohort of patients with predialysis CKD. Methods: Participants underwent protocolized baseline and semi-annual FGF23 testing, baseline and study end echocardiograms, and baseline and annual electrocardiograms over three years. Results: 2,254 participants (34.1% female; mean age 68.7 years; mean glomerular filtration rate 41.4 ml/min/m2) enrolled. Baseline LVH (left ventricular mass index >131 g/m2 (>100 g/m2 if female)) was present in 10.8% and prolonged QTc intervals (>=500 ms) in 1.5%. One hundred thirty-eight (6.1%) participants died during the study. In generalized mixed effects regression, each unit increase in the natural log of FGF23 - but not LVH - predicted an odds ratio of 1.76 (1.15, 2.70, p=0.009) for prolonged QTc intervals independently of 15 other covariates. Mediation analysis showed that only 13% of FGF23's total effect on prolonged QTc intervals was mediated by LVH. Patients with prolonged QTc intervals had higher unadjusted (log rank p<0.001) and adjusted (hazard ratio 3.15 (1.38, 7.16, p=0.006)) mortality rates than those with QTc intervals <500 ms. Conclusions: QTc interval prolongation ≥500 ms was prospectively associated with FGF23 independently of LVH, and with a tripling of mortality-risk in patients with predialysis CKD.

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Impact of preoperative QTc interval prolongation on short-term postoperative outcomes: A retrospective study

Ho,

Chung,

Kao

et al. 2024

Journal of Clinical Anesthesia

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Prolongation of the heart rate-corrected QT interval is associated with cardiovascular diseases: Systematic review and meta-analysis

Cited by 4 publications

References 69 publications

Electrocardiographic change: prolongation of the QT interval, imminent risk of sudden death

Electrocardiographic change: prolongation of the QT interval, imminent risk of sudden death

QTc interval prolongation independently associates with FGF23 and predicts mortality in predialysis CKD.

Impact of preoperative QTc interval prolongation on short-term postoperative outcomes: A retrospective study

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