Prolongation of P300 latency is associated with the duration of illness in male schizophrenia patients

Mori, Yoshio; Kurosu, Sadatoshi; Hiroyama, Yuji; Niwa, Shin‐Ichi

doi:10.1111/j.1440-1819.2007.01695.x

Cited by 16 publications

(5 citation statements)

References 44 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although we did not find any difference in pP3a and dP3a across different stages of the disease, our study showed a trend of P3a amplitude reduction in the group with the highest illness duration. These results are in line with previous studies which demonstrated that P3 amplitude is reduced in patients with longer illness duration [110,111,115,116]. Therefore, these findings suggest that P3, reflecting early attention-mediated auditory processing, might represent a marker of illness progression.…”

Section: Discussionsupporting

confidence: 92%

“…In fact, this ERP reflects early attention-mediated auditory processing, and consistent deficits of this index have been detected in subjects with schizophrenia [109][110][111][112][113] since the early stage of the disorder [90,114]. It has been demonstrated that P3 amplitude and latency are, respectively, decreased and delayed in patients with longer illness duration [110,111,115,116]. However, similar to MMN, the reduction in P3 amplitude is not specific of schizophrenia, as it can also be observed in other conditions, such as bipolar disorder and schizoaffective disorder [89,105,117].…”

Section: Introductionmentioning

confidence: 58%

See 1 more Smart Citation

Mismatch Negativity and P3a Impairment through Different Phases of Schizophrenia and Their Association with Real-Life Functioning

Giordano

Giuliani

Perrottelli

et al. 2021

JCM

View full text Add to dashboard Cite

Impairment in functioning since the onset of psychosis and further deterioration over time is a key aspect of subjects with schizophrenia (SCZ). Mismatch negativity (MMN) and P3a, indices of early attention processing that are often impaired in schizophrenia, might represent optimal electrophysiological candidate biomarkers of illness progression and poor outcome. However, contrasting findings are reported about the relationships between MMN-P3a and functioning. The study aimed to investigate in SCZ the influence of illness duration on MMN-P3a and the relationship of MMN-P3a with functioning. Pitch (p) and duration (d) MMN-P3a were investigated in 117 SCZ and 61 healthy controls (HCs). SCZ were divided into four illness duration groups: ≤ 5, 6 to 13, 14 to 18, and 19 to 32 years. p-MMN and d-MMN amplitude was reduced in SCZ compared to HCs, independently from illness duration, psychopathology, and neurocognitive deficits. p-MMN reduction was associated with lower “Work skills”. The p-P3a amplitude was reduced in the SCZ group with longest illness duration compared to HCs. No relationship between P3a and functioning was found. Our results suggested that MMN amplitude reduction might represent a biomarker of poor functioning in SCZ.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 58%

Mismatch Negativity and P3a Impairment through Different Phases of Schizophrenia and Their Association with Real-Life Functioning

Giordano

Giuliani

Perrottelli

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…Further, other studies [ 34 , 35 , 56 ] used patients who were treated with antipsychotic drugs, while our study concerned only antipsychotic-free patients. The discrepancy in presence/absence of prolonged P300 latency between a previous study [ 33 ] that also used antipsychotic-free patients and the current one may be explained by the difference in demographic data, such as age, a factor known to prolong P300 latency [ 58 , 59 ].…”

Section: Discussionmentioning

confidence: 72%

Prolonged P300 Latency in Antipsychotic-Free Subjects with At-Risk Mental States Who Later Developed Schizophrenia

Higuchi

Sumiyoshi

Tateno

et al. 2021

JPM

View full text Add to dashboard Cite

We measured P300, an event-related potential, in subjects with at-risk mental states (ARMS) and aimed to determine whether P300 parameter can predict progression to overt schizophrenia. Thirty-three subjects with ARMS, 39 with schizophrenia, and 28 healthy controls participated in the study. All subjects were antipsychotic-free. Subjects with ARMS were followed-up for more than two years. Cognitive function was measured by the Brief assessment of Cognition in Schizophrenia (BACS) and Schizophrenia Cognition Rating Scale (SCoRS), while the modified Global Assessment of Functioning (mGAF) was used to assess global function. Patients with schizophrenia showed smaller P300 amplitudes and prolonged latency at Pz compared to those of healthy controls and subjects with ARMS. During the follow-up period, eight out of 33 subjects with ARMS developed overt psychosis (ARMS-P) while 25 did not (ARMS-NP). P300 latency of ARMS-P was significantly longer than that of ARMS-NP. At baseline, ARMS-P elicited worse cognitive functions, as measured by the BACS and SCoRS compared to ARMS-NP. We also detected a significant relationship between P300 amplitudes and mGAF scores in ARMS subjects. Our results suggest the usefulness of prolonged P300 latency and cognitive impairment as a predictive marker of later development of schizophrenia in vulnerable individuals.

show abstract

“…While ageing and task difficulty are known to influence P300 performance, especially its latency (Mori et al, 2007;Polich, 1996); demographic confounders are unlikely to explain our findings and all analyses were adjusted for age and sex. Use of cannabis and other drugs is a known risk factor for psychosis (Arseneault et al, 2004) and since the at-risk group reported recreational drug consumption more often than the controls this could have contributed to our findings.…”

Section: Discussionmentioning

confidence: 87%

Abnormal P300 in people with high risk of developing psychosis

et al. 2008

View full text Add to dashboard Cite

Background: Individuals with an "At Risk Mental State" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable.Method: 35 cases meeting PACE criteria for the At Risk Mental State (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression.Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ±6.4 microvolt] compared to controls [12.7 ±5.8 microvolt] (p<0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Please find attached a fully revised manuscript titled "Abnormal P300 in people with high risk of developing psychosis". We also enclose a letter with the comments from the reviewers and our detailed answers on how we have done all the changes requested. (t-test; p=0.93). Those making a transition to psychosis were marginally more educated but this was only at trend level with a 3 year average difference in the age at which they completed their studies (t-test; p=0.07).Similarly, logistic regression analyses showed that compared to those who remained at risk, the seven cases who made a transition to psychosis had no significant differences in P300 amplitude/latency or N100 amplitude/latency (p values ranging from 0.30 to 0.63 for all four analyses). We have reported these comparisons very concisely and cautiously because referee #2 said that these analyses with only 7 individual making a transition were preliminary and power is limited. Please see results section paragraph 2. RESPONSE TO REVIEWER #2:Thank you for your suggestions, which have improved the paper. Below are your comments in blue-italics and how we have amended the manuscript accordingly in black with cross-references to the revised manuscript.This paper addresses an important and timely topic, namely, whether auditory P300 is reduced in subjects with at risk mental states and whether the P300 predicts subsequent conversion to psychosis. The study finds a significant deficit in P300 in ARMS subjects, relative to controls, replicating a previously a previously published report. The study had the potential to incrementally * 2. Response to Reviews 2 contribute to the literature by examining the utility of baseline P300 deficits as a predictor of subsequent conversion to psychosis; however, the negative finding coupled with the lack of power for this analysis (only 7 converters) make this aspect of the study inconclusive. More detailed comments are provided below:We have added a paragraph in the discussion to acknowledge the limitation of our small group of converters and how we have low statistical power to compa...

show abstract

Prolongation of P300 latency is associated with the duration of illness in male schizophrenia patients

Cited by 16 publications

References 44 publications

Mismatch Negativity and P3a Impairment through Different Phases of Schizophrenia and Their Association with Real-Life Functioning

Mismatch Negativity and P3a Impairment through Different Phases of Schizophrenia and Their Association with Real-Life Functioning

Prolonged P300 Latency in Antipsychotic-Free Subjects with At-Risk Mental States Who Later Developed Schizophrenia

Abnormal P300 in people with high risk of developing psychosis

Contact Info

Product

Resources

About