Prolongation of Both PT and aPTT

Silver, Bernard J.

doi:10.1007/978-1-4614-9560-4_5

Cited by 1 publication

(2 citation statements)

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“…The blood compatibility of wool materials containing keratin is crucial, and therefore, the assessment of the blood coagulation properties is very important in the context of their use in the medical sector. Activation partial thromboplastin time (aPTT) and pro-thrombin time (PT) tests are commonly used to assess the antithrombogenicity of the biomaterials in vitro [ 205 , 206 ]. The results obtained for the investigated wool–copper materials are presented in Figure 12 (aPTT) and Figure 13 (PT).…”

Section: Resultsmentioning

confidence: 99%

“…However, the presence of hydroxyl groups on the materials' surface promotes excellent hydrophilicity and leads to antibiofilm properties, which may contribute inhibition of the thrombogenesis process by limiting the formation of thrombi [203, The blood compatibility of wool materials containing keratin is crucial, and ther the assessment of the blood coagulation properties is very important in the context o use in the medical sector. Activation partial thromboplastin time (aPTT) and pro-thro time (PT) tests are commonly used to assess the antithrombogenicity of the biomat in vitro [205,206]. The results obtained for the investigated wool-copper materials ar sented in Figure 12 (aPTT) and Figure 13 (PT).…”

Section: Activated Partial Thromboplastin Time (Aptt) and Pro-thrombi...mentioning

confidence: 99%

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Biochemical Behavior, Influence on Cell DNA Condition, and Microbiological Properties of Wool and Wool–Copper Materials

Mrozińska,

Kaczmarek,

Świerczyńska

et al. 2024

Materials

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The paper presents the study concerning the preparation and physio-chemical and biological properties of wool–copper (WO-Cu) materials obtained by the sputter deposition of copper onto the wool fibers. The WO-Cu material was subjected to physio-chemical and biological investigations. The physio-chemical investigations included the elemental analysis of materials (C, N, O, S, and Cu), their microscopic analysis, and surface properties analysis (specific surface area and total pore volume). The biological investigations consisted of the antimicrobial activity tests of the WO-Cu materials against colonies of Gram-positive (Staphylococcus aureus) bacteria, Gram-negative (Escherichia coli) bacteria, and fungal mold species (Chaetomium globosum). Biochemical–hematological tests included the evaluation of the activated partial thromboplastin time and pro-thrombin time. The tested wool–copper demonstrated the ability to interact with the DNA in a time-dependent manner. These interactions led to the DNA’s breaking and degradation. The antimicrobial and antifungal activities of the WO-Cu materials suggest a potential application as an antibacterial/antifungal material. Wool–copper materials may be also used as customized materials where the blood coagulation process could be well controlled through the appropriate copper content.

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Section: Resultsmentioning

confidence: 99%

Section: Activated Partial Thromboplastin Time (Aptt) and Pro-thrombi...mentioning

confidence: 99%