Proline supplementation mitigates the early stage of liver injury in bile duct ligated rats

Heidari, Reza; Mohammadi, Hamidreza; Ghanbarinejad, Vahid; Ahmadi, Asrin; Ommati, Mohammad Mehdi; Niknahad, Hossein; Jamshidzadeh, Akram; Azarpira, Negar; Abdoli, Narges

doi:10.1515/jbcpp-2017-0221

Cited by 38 publications

(36 citation statements)

References 62 publications

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“…Samples were incubated at 37 °C (5 min, in the dark). Finally, the absorbance of developed color was measured (λ = 595 nm, EPOCH plate reader, BioTek ® Instruments, Highland Park, USA) (Alía et al., 2003; Heidari et al., 2019c).…”

Section: Methodsmentioning

confidence: 99%

The potential role of mitochondrial impairment in the pathogenesis of imatinib-induced renal injury

Emadi

Abdoli

Ghanbarinejad

et al. 2019

Heliyon

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Imatinib is a tyrosine kinase inhibitor widely administered against chronic myeloid leukemia. On the other hand, drug-induced kidney proximal tubular injury, electrolytes disturbances, and renal failure is a clinical complication associated with imatinib therapy. There is no precise cellular mechanism(s) for imatinib-induced renal injury. The current investigation aimed to evaluate the role of mitochondrial dysfunction and oxidative stress in the pathogenesis of imatinib nephrotoxicity. Rats received imatinib (50 and 100 mg/kg, oral, 14 consecutive days). Serum and urine biomarkers of renal injury and markers of oxidative stress in the kidney tissue were assessed. Moreover, kidney mitochondria were isolated, and mitochondrial indices, including mitochondrial depolarization, dehydrogenases activity, mitochondrial permeabilization, lipid peroxidation (LPO), mitochondrial glutathione levels, and ATP content were determined. A significant increase in serum (Creatinine; Cr and blood urea nitrogen; BUN) and urine (Glucose, protein, gamma-glutamyl transferase; γ-GT, and alkaline phosphatase; ALP) biomarkers of renal injury, as well as serum electrolytes disturbances (hypokalemia and hypophosphatemia), were evident in imatinib-treated animals. On the other hand, imatinib (100 mg/kg) caused an increase in kidney ROS and LPO. Renal tubular interstitial nephritis, tissue necrosis, and atrophy were evident as tissue histopathological changes in imatinib-treated rats. Mitochondrial parameters were also adversely affected by imatinib administration. These data represent mitochondrial impairment, renal tissue energy crisis, and oxidative stress as possible mechanisms involved in the pathogenesis of imatinib-induced renal injury and serum electrolytes disturbances.

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Section: Methodsmentioning

confidence: 99%

The potential role of mitochondrial impairment in the pathogenesis of imatinib-induced renal injury

Emadi

Abdoli

Ghanbarinejad

et al. 2019

Heliyon

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“…However, this research indicated monosaccharides of black beans, including α ‐arabinose, α ‐galactose may be also related to hepatoprotective effect. It is reported that the hepatoprotection provided by proline might be related to attenuating oxidative stress 57 . There are studies which showed that some flavonoids had liver protective activity, 58 flavonoids like daidzein and genistein also could ameliorate effect on CCl 4 ‐induced oxidative stress in the livers of rats 59 .…”

Section: Discussionmentioning

confidence: 99%

The composition differences between small black beans and big black beans from different habitats and its effects on the processing of Polygonum multiflorum

Chen

Wang

Chen

et al. 2020

Phytochemical Analysis

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Introduction The roots of Polygonum multiflorum (PM) serve as a classical traditional Chinese medicine (TCM), which has multiple biological activities. However, many cases of hepatotoxicity in PM have been reported in recent years. Processing PM with black beans decoction is one of the typical processing methods to reduce the hepatotoxicity of PM since ancient times. Objectives To find potential effective constituents, as well as the optimal variety and origin of black beans for the processing of PM. Methods Based on ultrahigh‐performance liquid chromatography Q‐Orbitrap mass spectrometry (UHPLC‐Q‐Orbitrap‐MS) analysis, we measured the contents of the two potential toxic compounds (emodin‐8‐O‐glucoside and torachrysone‐O‐hexose) in raw PM (R‐PM), PM processed with big black beans (B‐PM) and PM processed with small black beans (S‐PM). The flow cytometry method analysed the effects of different processed products of PM on apoptosis of L02 cells in different drug concentration. Proton nuclear magnetic resonance (1H‐NMR) and UHPLC‐Q‐Orbitrap‐MS together with multivariate statistical analysis were used to systematically analyse the different components between small black beans (Small‐BB) and big black beans (Big‐BB) from 30 different habitats. Results The toxicity was ranked from small to large: S‐PM < B‐PM < R‐PM. Processing PM with black beans could significantly decrease the apoptosis rate of L02 cells, especially when the drug concentration is 80 μg/mL. Besides, we find five differential compounds (α‐arabinose, α‐galactose, proline, isomer of daidzein and isomer of genistein) may be potential active ingredients. In terms of the black beans collected from 30 producing areas, we find that Small‐BB from Weifang in Shandong province was optimum to processing PM, followed by Shangqiu in Henan province, Jilin and Liaoning province. Conclusion The ingredients that affect the processing of PM may be attributed to α‐arabinose, α‐galactose, proline, isomer of daidzein and isomer of genistein in black beans. When the drug concentration is higher, the effect of reducing the hepatotoxicity of PM is better. Besides, Small‐BB was more effective than Big‐BB for reducing the toxicity of PM, especially Small‐BB from Weifang in Shandong, Shangqiu in Henan province and northeast China.

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“…Several studies have mentioned the positive effects of antioxidants against cholestasis [84][85][86]. N-acetyl cysteine, proline, α-lipoic acid, betaine, selenium, glycine, boldine, agmatine, and several other agents have been used to ameliorate cholestasis-induced organ injury [42,62,73,[87][88][89][90][91][92].…”

Section: Discussionmentioning

confidence: 99%

Taurine mitigates bile duct obstruction-associated cholemic nephropathy: effect on oxidative stress and mitochondrial parameters

Abdoli¹,

Sadeghian²,

Azarpira³

et al. 2021

ceh

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Aim of the study: Cholestasis is a serious complication affecting other organs such as the liver and kidney. Oxidative stress and mitochondrial impairment are proposed as the primary mechanisms for cholestasis-induced organ injury. Taurine (TAU) is the most abundant free amino acid in the human body, which is not incorporated in the structure of proteins. Several pharmacological effects have been attributed to TAU. It has been reported that TAU effectively mitigated oxidative stress and modulated mitochondrial function. The current study aimed to evaluate the impact of TAU on oxidative stress biomarkers and mitochondrial parameters in the kidney of cholestatic animals. Material and methods: Bile duct ligated (BDL) rats were used as an antioxidant model of cholestasis. Animals were treated with TAU (500 and 1000 mg/kg, oral) for seven consecutive days. Animals were anesthetized (thiopental 80 mg/kg, i.p.), and kidney and blood specimens were collected. Results: Severe elevation in serum and urine biomarkers of renal injury was evident in the BDL group. Significant lipid peroxidation, reactive oxygen species (ROS) formation, and protein carbonylation were detected in the kidney of BDL animals. Furthermore, depleted glutathione reservoirs and a significant decrease in the antioxidant capacity of renal tissue were detected in cholestatic rats. Renal tubular atrophy and interstitial inflammation were evident in BDL animals. Cholestasis also caused significant mitochondrial dysfunction in the kidney. TAU significantly prevented cholestasis-induced renal injury by inhibiting oxidative stress and mitochondrial impairment. Conclusions: These data indicate TAU as a potential therapeutic agent in the management of cholestasis-induced renal injury.

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Proline supplementation mitigates the early stage of liver injury in bile duct ligated rats

Cited by 38 publications

References 62 publications

The potential role of mitochondrial impairment in the pathogenesis of imatinib-induced renal injury

The potential role of mitochondrial impairment in the pathogenesis of imatinib-induced renal injury

The composition differences between small black beans and big black beans from different habitats and its effects on the processing of Polygonum multiflorum

Taurine mitigates bile duct obstruction-associated cholemic nephropathy: effect on oxidative stress and mitochondrial parameters

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