Climate change poses significant challenges to global agriculture, with rising temperatures, altered precipitation patterns, and increased frequency of extreme weather events threatening crop yields. These changes exceed the adaptability thresholds of many crops, decreasing their yield and threatening food security. At plant physiological levels, climate change‐induced stressors disrupt photosynthesis, growth, and reproductive processes, contributing to a reduced productivity. Furthermore, the negative impacts of climate change on agriculture are exacerbated by anthropogenic factors, with agriculture itself contributing significantly to greenhouse gas emissions. To mitigate these challenges, various approaches have been explored. This work reviews the most important physical, chemical, and biological strategies most commonly used in a broad range of agricultural crops. Among physical strategies, increasing water use efficiency without yield reduction through different irrigation strategies, and the use of foliar treatments with reflective properties to mitigate the negative effects of different stresses have been proven to be effective. Concerning chemical approaches, the exogenous treatment of plants with chemicals induces existing molecular and physiological plant defense mechanisms, enhancing abiotic stress tolerance. Regarding biological treatments, plant inoculation with mycorrhiza and plant growth‐promoting rhizobacteria (PGPR) can improve enzymatic antioxidant capacity and mineral solubilization, favoring root and plant growth and enhance plant performance under stressful conditions. While these strategies provide valuable short‐ to medium‐term solutions, there is a pressing need for new biotechnological approaches aimed at developing genotypes resistant to stressful conditions. Collaborative efforts among researchers, policymakers, and agricultural stakeholders are essential to ensure global food security in the face of ongoing climate challenges.