Proline homozygosity in codon 72 of TP53 is a factor of susceptibility to nasopharyngeal carcinoma in Tunisia

Hadhri-Guiga, Boutheina; Toumi, Nabil; Khabir, Abdelmajid; Sellami‐Boudawara, Tahya; Ghorbel, A.; Daoud, J.; Frikha, M.; Gargouri, Ali; Mokdad-Gargouri, Raja

doi:10.1016/j.cancergencyto.2007.05.013

Cited by 24 publications

(16 citation statements)

References 30 publications

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“…In contrast, other studies have demonstrated an association between the Pro72 (lower apoptotic activity) variant and increased risk for other cancers including thyroid, prostate and nasopharynx. Other studies did not find any association between TP53 codon 72 polymorphism and cancer (Hadhri-Guiga et al, 2007).…”

Section: Discussionmentioning

confidence: 76%

“…On the other hand, many studies have found a relationship between Pro72 allele and an increased risk for cancer. Hadhri-Guiga et al (2007) studied nasopharyngeal carcinomas and observed a significant association between cancer and TP53 codon 72 polymorphism; the Pro/Pro homozygotes are related to a higher risk for development of nasopharyngeal carcinomas. In a study on colorectal cancer, Zhu et al (2007) found evidence that the Pro72 variant allele may contribute to the etiology of this tumor; the Pro72 allele was found more often in patients than in controls (P < 0.001) and carriers of the Pro72 allele had a significantly increased risk of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

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Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors

Almeida

Custódio²,

Pinto³

et al. 2009

Genet. Mol. Res.

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AbSTRACT. The p53 tumor suppressor gene is the most frequently mutated gene in human cancer; this gene is mutated in up to 50% of human tumors. It has a critical role in the cell cycle, apoptosis and cell senescence, and it participates in many crucial physiological and pathological processes. Polymorphisms of p53 have been suggested to be associated with genetically determined susceptibility in various types of cancer. Another process involved with the Aberrant methylation of the promoter is an alternative epigenetic change in genetic mechanisms, leading to tumor suppressor gene inactivation. In the present study, we examined the TP53 Arg72Pro and Pro47Ser polymorphisms using PCR-RFLP and the pattern of methylation of the p53 gene by methylation-specific PCR in 90 extra-axial brain tumor samples. Patients who had the allele Pro of the TP53 Arg72Pro polymorphism had an increased risk of tumor development (odds ratio, OR = 3.23; confidence interval at 95%, 95%CI = 1.71-6.08; P = 0.003), as did the allele Ser of TP53 Pro47Ser polymorphism (OR = 1.28; 95%CI = 0.03-2.10; P = 0.01).Comparison of overall survival of patients did not show significant differences. In the analysis of DNA methylation, we observed that 37.5% of meningiomas, 30% of schwannomas and 52.6% of metastases were hypermethylated, suggesting that methylation is important for tumor progression. We suggest that TP53 Pro47Ser and Arg72Pro polymorphisms and DNA hypermethylation are involved in susceptibility for developing extra-axial brain tumors.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors

Almeida

Custódio²,

Pinto³

et al. 2009

Genet. Mol. Res.

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“…the relationship between the p53 codon 72 polymorphism and metastasis has been analyzed in several types of cancer. hadhri et al [26] demonstrated that the genotype frequency did not significantly differ between the p53 codon 72 polymorphism and lymph node metastasis in patients with nasopharyngeal carcinoma. Wang et al [27] found that arg allele was associated with liver metastasis in colorectal patients.…”

Section: Discussionmentioning

confidence: 98%

The p53 codon 72 polymorphism and susceptibility to colorectal cancer in Korean patients

Cao¹,

Jh²,

Yk³

et al. 2009

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TP53 is a major gene involved in the determination of proliferation or growth arrest at the cellular level. The polymorphism of p53 at codon 72 has been widely studied; this variation has been associated with cancer susceptibility and disease outcome. The specific aim of this study was to investigate whether the p53 codon 72 polymorphism is associated with individual susceptibility to colorectal cancer in Korean patients. The frequency of the polymorphism was examined in 156 patients with colorectal cancer and in 293 healthy controls. The polymorphism analysis was performed by amplifying exon 4 of p53 and digesting the products with restriction enzyme. The frequencies of genotypes: Arg/Arg, Arg/Pro and Pro/Pro were 34.6% (54/156), 43.0% (67/156) and 22.4% (35/156), respectively, in the cases with colorectal cancer, and 28.9% (114/293), 47.8% (140/293) and 13.3% (39/293), respectively, in the healthy controls. Statistically, there was a significant difference in the frequency of the genotypes when the healthy controls were compared to the patients with colorectal cancer (p=0.0459). The specific allele frequencies showed borderline significance (p=0.0502). Our findings suggest that the p53 Pro72 variant is associated with an increased risk for colorectal cancer in the Korean population.

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“…Shen et al (2002) analyzed oral, pharyngeal, and laryngeal cancer specifically, whereas Ji et al (2008) and Chen et al (2008) studied oropharyngeal cancer as well as oral cancer. Overall, a total of 27 studies consisting of 3966 HNCs cases and 4387 controls were included in our meta-analysis (Yung et al, 1997;Golovleva et al, 1997;McWilliams et al, 2000;Hamel et al, 2000;Summersgill et al, 2000;Tandle et al, 2001;Sourvinos et al, 2001;Nagpal et al, 2002;Shen et al, 2002;Tsai et al, 2002;Tiwawech et al, 2003;Kietthubthew et al, 2003;Katiyar et al, 2003;Scheckenbach et al, 2004;Cortezzi et al, 2004;Hsieh et al, 2005;Sousa et al, 2006;Twu et al, 2006;Hadhri-Guiga et al, 2007;Perrone et al, 2007;Kuroda et al, 2007;Ji et al, 2008;Chen et al, 2007Chen et al, , 2008Lin et al, 2008;Tu et al, 2008;Misra et al, 2009) (Table 2). The genotype distribution of the TP53 Arg72Pro polymorphism is summarized in Table 3.…”

Section: Literature Search Screening and Data Collectionmentioning

confidence: 99%

“…However, the results are conflicting and inconclusive (Yung et al, 1997;Nagpal et al, 2002;Hadhri-Guiga et al, 2007), which may be partially due to differences among the populations studied, as well as particular methodological and study design features. Hence, we performed a meta-analysis of all eligible studies to derive a more precise estimation of the association, which may help to clarify the possible influence of this SNP on the risk of HNCs.…”

Section: Introductionmentioning

confidence: 98%

Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies

et al. 2014

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ABSTRACT. Genetic factors have been shown to play a role in the development of head and neck cancers (HNCs). However, studies investigating the association between the TP53 Arg72Pro polymorphism and HNCs susceptibility have yielded conflicting results. Hence, we performed a meta-analysis of all eligible studies (up to January 1, 2012) to derive a more precise estimation of this association in order to increase understanding of the possible risk factors of HNCs. Twenty-seven casecontrol studies involving 3966 cases and 4387 controls were included in our analysis. Overall, no evidence of association was observed between the TP53 Arg72Pro single nucleotide polymorphism (SNP) and the risk of effects across different subtypes of HNCs. For example, there was a lack of association of this polymorphism with oral cavity cancer, whereas a significant association with nasopharyngeal cancer was observed. Results of this meta-analysis suggest that the TP53 Arg72Pro polymorphism might have different effects on the risk of various subtypes of HNCs.

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Proline homozygosity in codon 72 of TP53 is a factor of susceptibility to nasopharyngeal carcinoma in Tunisia

Cited by 24 publications

References 30 publications

Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors

Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors

The p53 codon 72 polymorphism and susceptibility to colorectal cancer in Korean patients

Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies

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