Proline Decreases the Suppressive Effect of Histidine on Food Intake and Fat Accumulation

Abstract

SummaryWe recently suggested that proline might decrease the suppressive effect of histidine on food intake. Our purpose in the present study was to investigate the influence of proline on the suppressive effect of histidine on food intake and accumulation of body fat. Male Wistar rats were divided into four groups and allowed free access to the following diets for 3 wk: control (C), 5% proline (P), 5% histidine (H), or 5% histidine plus 10% proline (HP) diets. Food intake for 7 d and retroperitoneal fat tissue weight at the end of the experimental period of the HP diet group were greater than those of the H diet group, whereas no significant difference existed between the HP diet group and the C diet group. Our results indicate that proline inhibits the influence of histidine on food intake and accumulation of body fat.

Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

“…Altered function of the immune system, allergic reactions, and/or peptic ulcers have not been reported after HIS administration. However, HIS administration has been shown to affect brain function [62][63][64][65][66][67][68].…”

“…Increased HIS intake in the form of a dried bonito broth has improved mood state and mental task performance of human subjects [33,34,36]. Several studies have reported an anorectic effect of HIS administration [65][66][67][68] and HIS-enriched diet [62][63][64]. Insufficient HIS intake reduces the brain histamine content and is associated with anxiety-like behaviors in mice [61].…”

“…Although HIS is a precursor of histamine, allergic reactions or peptic ulcers caused by increased gastric acid secretion have not been reported. Practically important might be reduced folate status [45,46,126], anorexia [62][63][64][65][66][67][68][69], and increased loss of zinc in urine reported after HIS administration in overweight subjects and patients with progressive systemic sclerosis [135,136]. Several metabolic alterations noted below indicate that increased HIS consumption is inappropriate in subjects with liver injury.…”

Histidine: A Systematic Review on Metabolism and Physiological Effects in Human and Different Animal Species

“…In contrast to histamine, histidine can cross the blood brain barrier. After crossing the blood-brain barrier, and once in the tuberomammilary nucleus (TMN) of the hypothalamus, histidine is converted into histamine by histidine decarboxylase [20]. Subsequently, histamine is oxidized to imidazoleacetaldehyde and then to imidazoleacetic acid [11].…”

“…Histamine is a neurotransmitter [23] that plays a role in the control of food intake, along with other neurotransmitters (catecholamines, 5-hydroxytryptamine). Studies have shown that histidine decreases food intake through histamine [20,21]. Vaziri et al studied the effect of histidine administered by intragastric or intraperitoneal routes to rats and measured food intake after blocking the conversion of histidine to histamine by FMH, a-fluoromethylhistidine.…”