PROLIFERATIVE POTENTIALITY OF AMELOBLASTOMA BY EXPRESSION OF Ki-67

Abstract

Ameloblastoma is a type of Odontogenic tumor, commonly encountered in orofacial region. It is very aggressive in nature with potential features of recurrence. Ki -67 is already a proven proliferative marker, which is used in our study to assess the proliferative potentiality of Ameloblastoma. Incisional biopsy was done from 10 cases of Ameloblastoma and 5 normal cases as control, at the department of Oral pathology and Microbiology, BIDSH, Patna. Each specimen was processed and two sections were prepared and stained with hematoxylin and eosin and Ki-67 immunohistochemical marker. Positive stained cells with with Ki-67 in ameloblastoma along with normal epithelium were counted from four randomly selected areas and were quantied using a microscope at 400x magnication. Positive correlation seen with Ki-67 positive cells and percentages, which indicates the value of one variable increases, the other also increases. The overall conclusion is that Ki-67 expression can be used as a prognostic marker in Ameloblastoma.