Proliferative potential in pituitary adenomas: Measurement by monoclonal antibody MIB-1

Abe, Takumi; Sanno, Naoko; Osamura, Yoshiyuki; Matsumoto, Kiyoshi

doi:10.1007/bf01411995

Cited by 42 publications

(22 citation statements)

References 23 publications

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“…On the other hand, some other studies did not show any significant correlation between MIB-1 index and CS invasion. 1,5,14,22,28,33) Whether invasive potential affects progression remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…8,18) Various attempts have been made to establish markers that correlate with the clinical behavior of pituitary adenomas, such as invasion, recurrence, or malignancy. 1,2,5,[7][8][9][10][12][13][14][15]17,[19][20][21][22][23][24][27][28][29][30][31][32][33] Among the available methods of growth fraction determination, Ki-67 is a reliable marker for growth fraction determination of various specific cell cycle antigens. 1,12,32) Ki-67 is a protein which reacts with a …”

Section: Introductionmentioning

confidence: 99%

“…1,12,33) Several studies suggest that high Ki-67 values predict more aggressive behavior, [1][2][3]8,9,12,20,21) but no firm consensus has been reached regarding a precise cutoff value. The present study investigated the use of MIB-1 proliferating cell index to predict re-growth of residual pituitary adenomas after surgery and the correlations between various clinical variables and MIB-1 index in patients with pituitary adenomas with and without rapid re-growth after initial surgery.…”

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confidence: 99%

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Ki-67 Expression for Predicting Progression of Postoperative Residual Pituitary Adenomas: Correlations With Clinical Variables

Matsuyama

2012

Neurol. Med. Chir.(Tokyo)

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Reliable prognostic parameters indicating progression in residual pituitary adenoma after surgery are necessary. The World Health Organization classification of tumors of endocrine organs defines atypical pituitary adenomas as tumor with Ki-67 labeling index higher than 3%, excessive p53 immunoreactivity, and increased pleomorphism. The real value of Ki-67 labeling index correlating with tumor progression is controversial. We investigated the relationship between positive labeling for MIB-1 and clinical features of 39 patients with pituitary adenomas with and without rapid re-growth after initial surgery. Ki-67 expression revealed pituitary adenomas with progression (re-growth within 5 years after initial surgery) had a mean proliferation index of 3.66 ± 3.00% (mean ± standard deviation [SD], n ＝ 12), which was significantly higher than in tumors without progression of 1.89 ± 1.25% (mean ± SD, n ＝ 27) (p º 0.05, Mann-Whitney test). Receiver operating characteristic analysis showed a threshold level of Ki-67 expression greater than 2.0% predicts progression with high specificity. Younger patients had higher MIB-1 index and more progression (p º 0.05). Adenomas with cavernous sinus invasion, functioning adenomas, and giant adenomas had higher MIB-1 index (p º 0.05). There was no significant correlation between tumor size or cavernous sinus invasion and progression. More completely removed tumors were less progressive. A threshold of 2% for the MIB-1 labeling index predicts higher risk of progression of residual adenomas after surgery, so shorter interval of follow-up neuroimaging, and early initiation of adjuvant therapy might be required.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Ki-67 Expression for Predicting Progression of Postoperative Residual Pituitary Adenomas: Correlations With Clinical Variables

Matsuyama

2012

Neurol. Med. Chir.(Tokyo)

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“…The MIB-1 antibody permits detection of Ki-67 antigen in formalin-fixed, paraffin-embedded tissues. In pituitary adenomas, several reports suggested that MIB-1 labeling index concords with cell proliferation (18,19).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Analysis of RCAS1 in Human Pituitary Adenomas

et al. 2001

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“…O tumor no qual se observou apenas invasão era não-secretor e media l,84xl,84cm à tomografia computadorizada (TC). Foi demonstrado que adenomas recorrentes têm taxa proliferativa significativamente mais alta que os tumores iniciais (28). Além disso, adenomas pequenos têm potencial de crescimento limitado quando comparados com macroadenomas invasivos (17).…”

Section: Discussionunclassified

Avaliação da atividade secretora, proliferação celular e expressão da proteína p27 em tumores hipofisários

Lima

Rios

Oliveira

et al. 2000

Arq Bras Endocrinol Metab

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A finalidade deste estudo foi avaliar a atividade secretora, proliferação celular e inibição do ciclo celular das neoplasias hipofisárias. Os tecidos foram obtidos de 13 pacientes incluindo acromegalia (n=5), adenomas não-secretores (n=4), hiperprolactinemia (n=3) e doença de Cushing (n=1). Os espécimes foram examinados por técnica imuno-histoquímica com anticorpos anti-ACTH, anti-TSH, anti-LH, anti-FSH, anti-PRL, anti-hGH, anti-MIB-1 (análise da proliferação celular) e anti-p27 (análise da inibição do ciclo celular). A expressão imuno-histoquímica quanto à atividade secretora nos tumores hipofisários demonstrou que todos produziam mais que um hormônio. As células positivas para o marcador de proliferação celular MIB-1 mostraram-se presentes em aproximadamente 46% dos casos. A maior taxa proliferativa foi encontrada nos tumores com quadro clínico de acromegalia (80% dos casos). A taxa de positividade para a proteína p27 foi de aproximadamente 38%, sendo, em média, maior no tumor responsável pela doença de Cushing. Esses resultados demonstram que os adenomas multisecretores são relativamente comuns. Os índices de proliferação celular baixos e os níveis de p27 próximos àqueles observados em tecidos normais expressam o baixo nível de proliferação celular destes tumores. ABSTRACTThe aim of this study was to evaluate the secretory activity, cell proliferation and inhibition of the cell cycle of pituitary neoplasm. Tissues were obtained from 13 patients presenting with acromegaly (n=5), non-secreting adenomas (n=4), hyperprolactinemia (n=3) and Cushing's disease (n=1). Specimens were examined by an immunohistochemical technique using anti-ACTH, anti-TSH, anti-LH, anti-FSH, anti-PRL, anti-hGH, anti-MIB-1 (analysis of cell proliferation) and anti-p27 (analysis of cell cycle inhibition) antibodies. Regarding secretory activity all tumors produced more than one hormone. Cells positive for MIB-1 were present in approximately 46% of the cases. The highest incidence of proliferation was found in those presenting acromegaly (80% of the cases). Expression of the p27 protein was positive in approximately 38%, being on an average, highest in Cushing's disease. These results demonstrate the presence of multisecretory pituitary adenomas, a relative common finding. The relatively low cell proliferation indexes and the near normal tissue levels of p27 confirm that these tumors grow at a rather slow rate.

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Proliferative potential in pituitary adenomas: Measurement by monoclonal antibody MIB-1

Cited by 42 publications

References 23 publications

Ki-67 Expression for Predicting Progression of Postoperative Residual Pituitary Adenomas: Correlations With Clinical Variables

Ki-67 Expression for Predicting Progression of Postoperative Residual Pituitary Adenomas: Correlations With Clinical Variables

Immunohistochemical Analysis of RCAS1 in Human Pituitary Adenomas

Avaliação da atividade secretora, proliferação celular e expressão da proteína p27 em tumores hipofisários

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