Proliferative, lymphocytic, infundibular mural folliculitis and dermatitis with prominent follicular apoptosis and parakeratotic casts in four Labrador retrievers: preliminary description and response to therapy

Abstract

The cause of the lesions is unknown; the presence of intraepithelial CD3+ lymphocytes and cleaved caspase-3-positive apoptotic keratinocytes and the positive response to immunosuppressive therapy suggest an immune response directed towards unidentified antigens expressed on the surface of keratinocytes.

Erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis: a comparative review

“…Clinical response after 6 weeks of oral vitamin A treatment. Dog 1 was also illustrated in the report by Hargis et al . Dog 2 was also illustrated in a report by Parker et al…”

“…Immunosuppressive drugs have been used successfully in treating hyperkeratotic disorders with underlying lesions of epidermal cytotoxicity. Ciclosporin was efficacious in PLIMFD; however, the dosage required and the duration of therapy varied from dog to dog. Topical tacrolimus (0.1%) is effective in feline PNOE …”

“…These conditions include the ciclosporin-responsive 'proliferative, lymphocytic, infundibular mural folliculitis and dermatitis with prominent follicular apoptosis and parakeratotic casts' (PLIMFD), typically in young Labrador retrievers. 127 (Figure 9a,c,e). A very similar case, also in a Labrador retriever puppy, was reported in 1983 (Figure 9b,d,f).…”

“…Additionally, lesions have a distinctly follicular bias. These conditions include the ciclosporin‐responsive ‘proliferative, lymphocytic, infundibular mural folliculitis and dermatitis with prominent follicular apoptosis and parakeratotic casts’ (PLIMFD), typically in young Labrador retrievers . (Figure a,c,e).…”

Localized parakeratotic hyperkeratosis in sixteen Boston terrier dogs

“…More severe congenital follicular parakeratosis has been reported in Labrador retrievers, Rottweilers and a Siberian husky with multifocal adherent plaques of frond‐like keratin in conjunction with stunted growth and other birth defects . An acquired form of follicular apoptosis and parakeratotic casts that may respond to immunosuppressive therapy has been described in adult Labrador retrievers …”