2011
DOI: 10.1007/s12031-011-9691-3
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Proliferative Enteropathy (PE)—Induced Changes in the Calbindin-Immunoreactive (CB-IR) Neurons of Inferior Mesenteric Ganglion Supplying the Descending Colon in the Pig

Abstract: A subpopulation of the pig inferior mesenteric ganglia (IMG) neurons projecting to the colon exhibit calbindin-like immunoreactivity. It is not known if there are any changes in the chemical coding patterns of these neurons during porcine proliferative enteropathy (PE). To answer this question, juvenile Large White Polish pigs with clinically diagnosed Lawsonia intracellularis infection (PE; n = 3) and a group of uninfected controls (C; n = 3) were compared. The retrograde tracer fast blue (FB) was injected in… Show more

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Cited by 17 publications
(26 citation statements)
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“…Two facts confirm this supposition. Firstly, it is well known that the expression of neuroprotective factors in the ENS increases during pathological processes [5,6,42,43], and the growth of CGRP-like immunoreactivity has been observed during both the present study and in previous investigations on other fragments of the digestive tract [44]. Secondly, CGRP affects the release of nitric oxide, whose neuroprotective activity is relatively well surveyed [45,46,47].…”
Section: Discussionsupporting
confidence: 66%
“…Two facts confirm this supposition. Firstly, it is well known that the expression of neuroprotective factors in the ENS increases during pathological processes [5,6,42,43], and the growth of CGRP-like immunoreactivity has been observed during both the present study and in previous investigations on other fragments of the digestive tract [44]. Secondly, CGRP affects the release of nitric oxide, whose neuroprotective activity is relatively well surveyed [45,46,47].…”
Section: Discussionsupporting
confidence: 66%
“…One not fully elucidated problem is the participation of neuronal substances in pathological processes. Contrary to the stomach and intestine, where reactions of the ENS to various diseases are relatively well known (Gonkowski, Burlinski et al., ; Wojtkiewicz et al., , ), the knowledge of the contribution of oesophageal neurons in adaptive and/or neuroprotective processes under pathological factors is rather scanty. As acknowledged, previous studies have described changes in the expression of various neuronal active substances within oesophageal nervous structures during different diseases, including reflux disease (Xu et al., ), meso‐oesophagus (Nascimento et al., ), as well as oesophageal stenosis (Singaram, Sweet, Gaumnitz, Cameron, & Camilleri, ) and atresia (Cheng, Bishop, Spitz, & Polak, ), but the exact mechanisms of these changes remain unknown.…”
Section: Discussionmentioning
confidence: 99%
“…Enteric neurons are involved in all aspects of the GI tract physiology, such as intestinal motility, blood flow, nutrient absorption and the exudation of digestive enzymes (Furness et al., ). Moreover, it is relatively well established that they also take part in the intestinal and extraintestinal pathological processes by participating in neuroprotective and adaptive reactions in response to disturbances in homeostasis (Gonkowski, ; Vasina et al., ; Wojtkiewicz et al., ). Neurons innervating the GI tract exhibit significant differentiation in morphology, physiology and electrophysiological properties (Dong, Jiang, Srinivasan, & Mittal, ).…”
Section: Introductionmentioning
confidence: 99%
“…The number of PACAP-containing perikarya also increased in all cases in the myenteric and submucosal plexus, except for the outer submucosal plexus in case of axotomy-induced pathology. In another study, Wojtkiewicz et al [ 83 ] described infl ammation-induced changes in the neurochemical composition of the inferior mesenteric ganglia supplying the lower portion of the colon in pigs. Although PACAP was not investigated, they found that the number of VIP immunoreactive neurons was reduced in proliferative enteropathy.…”
Section: Effects Of Pacap In Large Intestinal Infl Ammationmentioning
confidence: 99%