Proliferative Effects of Bovine and Porcine Thyroglobulins on Thyroid Epithelial Cells

Hayashi, Masanori; Shimonaka, Motoyuki; Matsui, Kozo; Hayashi, Takayuki; Ochiai, Daisuke; Emoto, Naoya

doi:10.1507/endocrj.k08e-345

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Thyroid hormones reach their target organs via the bloodstream. Thyroglobulin has been reported to regulate some thyroid genes and the growth of epithelial cells [9,10]. It acts as both a hormone and an iodine reservoir [11].…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic analysis of the human thyroglobulin regions

et al. 2012

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Thyroglobulin is a large protein present in all vertebrates. It is synthesized in the thyrocytes and exported to lumen of the thyroid follicle, where its tyrosine residues are iodinated . The iodinated thyroglobulin is reintegrated into the cell and processed (cleaved to free its two extremities) for thyroid hormone synthesis. Thyroglobulin sequence analysis has identified four regions of the molecule: Tg1, Tg2, Tg3 and ChEL. Structural abnormalities and mutations result in different pathological consequences, depending on the thyroglobulin region affected. We carried out a bioinformatic analysis of thyroglobulin, determining the origin and the function of each region. Our results suggest that the Tg1 region acts as a binding protein on the apical membrane, the Tg2 region is involved in protein adhesion and the Tg3 region is involved in determining the three-dimensional structure of the protein. The ChEL domain is involved in thyroglobulin transport, dimerization and adhesion. The presence of repetitive domains in the Tg1, Tg2 and Tg3 regions suggests that these domains may have arisen through duplication.

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Section: Introductionmentioning

confidence: 99%

Phylogenetic analysis of the human thyroglobulin regions

et al. 2012

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“…Biosynthesis of thyroid hormones is critically dependent upon the native three-dimensional structure of TG. The TG has been proposed as a transcriptional regulator on thyroid-specific genes (Suzuki et al, 1998) and more recently, as a direct growth regulator of thyroid epithelial cells (Hayashi et al, 2009). The study of TG is of great relevance to thyroid pathophysiology.…”

Section: Introductionmentioning

confidence: 99%

Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations

Targovnik

Esperante

Rivolta

2010

Molecular and Cellular Endocrinology

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An Evolutionary Genomic Perspective on the Breeding of Dwarf Chickens

Wang

Otecko

Wang

et al. 2017

Molecular Biology and Evolution

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The evolutionary history for dwarfism in chickens remains an enigma. Herein, we explore the evolution of the Serama, the smallest breed of chicken. Leveraging comparative population genomics, analyses identify several genes that are potentially associated with the growth and development of bones and muscles. These genes, and in particular both POU1F1 and IGF1, are under strong positive selection. Three allopatric dwarf bantams (Serama, Yuanbao, and Daweishan) with different breeding-histories, form distinct clusters and exhibit unique population structures. Parallel genetic mechanisms underlay their variation in body size. These findings provide insights into the multiple and complex pathways, depending on genomic variation, that chicken can take in response to aviculture selection for dwarfism.

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Proliferative Effects of Bovine and Porcine Thyroglobulins on Thyroid Epithelial Cells

Cited by 3 publications

References 34 publications

Phylogenetic analysis of the human thyroglobulin regions

Phylogenetic analysis of the human thyroglobulin regions

Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations

An Evolutionary Genomic Perspective on the Breeding of Dwarf Chickens

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