Proliferative Effect of Food Plant Species from Brazil's Cerrado on Cultured Fibroblasts

Chemical and cytotoxicity profiles of 11 pink pepper (Schinus spp.) samples via non-targeted hyphenated high-performance thin-layer chromatography

“…The search for cytotoxic compounds is interesting in such samples in the context of discovering novel anti-cancer or anti-tumor agents, to improve selectivity towards tumor cells as well as to avoid resistance to commonly used therapies. For both Schinus species, previous works have shown that non-polar to mid-polar extracts obtained from the different plant parts (Garzoli et al, 2019 ; Mügge et al, 2021 ; Oliveira et al, 2018 ; Ovidi et al, 2021 ) and the essential oil obtained from the leaves (Díaz et al, 2008 ; Garzoli et al, 2019 ; Mahmoud et al, 2011 ; Santana et al, 2012 ) or fruits (Aboalhaija et al, 2019 ; Bendaoud et al, 2010 ; Guzzo da Silva et al, 2019 ; Matsuo et al, 2011 ; Oliveira et al, 2018 ) are active against different cancer cell lines. Most cytostatic or cytotoxic compounds used today in cancer treatment are derived from plants (Beutler, 2019 ; Davison & Brimble, 2019 ), but the advances in this field are slow due to the difficulty in applying high-throughput methods, which are useful for screening synthetic molecule libraries, to complex mixtures obtained from plant parts (Beutler, 2019 ; Davison & Brimble, 2019 ; Hackman et al, 2020 ; Huo et al, 2022 ; Mazumder et al, 2018 ; Najmi et al, 2022 ).…”