Proliferative Activity, Apoptosis and Expression of Oestrogen Receptor and Bcl-2 Oncoprotein in Canine Mammary Gland Tumours

Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours

“…PI scores of simple solid carcinomas were higher than the other carcinomas (23). On the contrary, in another study (32), PI scores of simple tubulopapillary carcinomas were found to be higher than those of solid carcinomas, yet with complex carcinomas showing the highest PI values. In this study, PI scores of mammary carcinomas of epithelial origin, such as simple solid carcinomas and spindle cell carcinomas, were higher than those of carcinosarcomas, complex carcinomas, and osteosarcomas which consist of both epithelial and myoepithelial tissues, as well as cells of mesenchymal origin.…”

Sequence and partial functional analysis of canine Bcl-2 family proteins

“…Bcl-2 family proteins have been assigned a central importance in the pathogenesis of various human cancer syndromes (Kelly and Strasser, 2011;Nys and Agostinis, 2012). Likewise, they have been implicated in the pathogenesis of diverse canine tumors including for instance hemangiosarcoma, mammary tumors, tumors of neural and hematopoetic origin (Sano et al, 2003;Kumaraguruparan et al, 2006a;Kumaraguruparan et al, 2006b;Yan et al, 2006;Murakami et al, 2008;Ide et al, 2010;Strefezzi et al, 2012;Dettwiler et al, 2013).…”

486 From the 1 Department of Pathology, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia, 2 Department of Surgery, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia, 3 Department of Anatomy, Faculty of Medicine, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia Received: Jan. 18, 2011; Accept: Mar. 8, 2012 Correspondence to: Dr. Siti Aishah Md Ali, Department of Pathology, Faculty of Medicine, University

“…[1,[6][7][8] Apoptosis is one of the factors that play a key role in the development and growth regulation of normal and neoplastic mammary tissues. [9,10] Bcl2 is an oncoprotein that plays a role in apoptosis; by blocking programmed cell death, discourages the promotion of cellular proliferation and induces tumor development. [10,11] The expression of Bcl2 is associated with cells that are protected from apoptosis such as stem cells or epithelia that undergo hyperplasia; including breast and prostate and its expression is related to steroid hormone receptor.…”

“…[9,10] Bcl2 is an oncoprotein that plays a role in apoptosis; by blocking programmed cell death, discourages the promotion of cellular proliferation and induces tumor development. [10,11] The expression of Bcl2 is associated with cells that are protected from apoptosis such as stem cells or epithelia that undergo hyperplasia; including breast and prostate and its expression is related to steroid hormone receptor. [10,12] The estrogen receptor (ER), is ligand-activated transcription factors that normally present in normal and benign lesions of the breast.…”

“…[10,11] The expression of Bcl2 is associated with cells that are protected from apoptosis such as stem cells or epithelia that undergo hyperplasia; including breast and prostate and its expression is related to steroid hormone receptor. [10,12] The estrogen receptor (ER), is ligand-activated transcription factors that normally present in normal and benign lesions of the breast. [10,13] Generally, ER has been implicated in both normal and neoplastic mammary tissue as a DNA binding transcription factor and induces cell proliferation.…”