Proliferation of resting B cells is modulated by CR2 and CR1

Fingeroth, Joyce D.; Heath, Margo E.; Ambrosino, Donna M.

doi:10.1016/0165-2478(89)90022-9

Cited by 53 publications

(35 citation statements)

References 49 publications

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“…In contrast to CR2, the intracytoplasmic of human CR1 does not seem to have the ability of transducing signals. Yet data obtained earlier with antireceptor Abs (28,29) suggest that CR1 has signal-mediating capacity, either itself or via associated molecules. This is clearly supported by the results of our experiments, since BCRinduced elevation of [Ca 2ϩ ] i is inhibited, and tyrosine phosphorylation of certain cytoplasmic proteins is strongly reduced upon clustering CR1 (Figs.…”

Section: Discussionmentioning

confidence: 91%

“…Tedder et al (24) showed no effect of CR1-specific Ab on the anti--induced proliferation and on Ig production of PWM-stimulated blood B cells, while other groups reported both CR1-mediated enhancement (22,23) and inhibition (25,26) of Ig synthesis. Using receptor-specific Abs, Fingeroth et al (29) reported that cocross-linking of sIg and CR1 on resting splenic B cells results in inhibition of the antiIgM-induced proliferation. Carter et al (28) obtained similar results with blood B cells.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding proliferation of human B cells, data are controversial as well. An inhibitory effect of CR1-sIg cross-linking was shown on peripheral blood B cells (28) and on resting splenic B cells (29), while others reported no role of CR1 in the anti--induced B cell proliferation (23,24,27). The controversy found in literature regarding the function of CR1 on human B cells is most probably due to the different experimental conditions, the use of mixed cell populations and Abs that react with various epitopes of CR1.…”

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confidence: 99%

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Complement Receptor Type 1 (CD35) Mediates Inhibitory Signals in Human B Lymphocytes

Józsi¹,

Prechl

Bajtay

et al. 2002

The Journal of Immunology

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The complement system—particularly component C3—has been demonstrated to be a key link between innate and adaptive immunity. The trimolecular complex of complement receptor type 2 (CR2), CD19, and CD81 is known to promote B cell activation when coligated with the B cell Ag receptor. In the present study, we aimed to elucidate the role of human complement receptor type 1 (CR1), the other C3-receptor on B cells. As ligand, aggregated C3 and aggregated C3(H2O), i.e., multimeric “C3b-like C3”, are used, which bind to CR1, but not to CR2. In experiments studying the functional consequences of CR1-clustering, the multimeric ligand is shown to inhibit the proliferation of tonsil B cells activated with a suboptimal dose of anti-IgM F(ab′)2. Importantly, this inhibitory activity also occurs in the presence of the costimulatory cytokines IL-2 and IL-15. The anti-IgM-induced transient increase in the concentration of intracellular free Ca2+ and phosphorylation of several cytoplasmic proteins are strongly reduced in the presence of the CR1 ligand. Data presented indicate that CR1 has a negative regulatory role in the B cell Ag receptor mediated activation of human B lymphocytes.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Complement Receptor Type 1 (CD35) Mediates Inhibitory Signals in Human B Lymphocytes

Józsi¹,

Prechl

Bajtay

et al. 2002

The Journal of Immunology

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“…We have hypothesized that CD21 may be important in regulating autoimmune responses by lowering the threshold for induction of B cell tolerance, just as it lowers the threshold for B cell activation (16,23,24). In addition, it may be involved in the targeting of self-Ags to follicular dendritic cells in secondary lymphoid organs (25,26), which may be required for the maintenance of peripheral B cell tolerance.…”

Section: Discussionmentioning

confidence: 99%

Augmentation of NZB Autoimmune Phenotypes by the Sle1c Murine Lupus Susceptibility Interval

Giles

Tchepeleva

Kachinski

et al. 2007

The Journal of Immunology

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The Sle1c lupus susceptibility interval spans a 7-Mb region on distal murine chromosome 1. Cr2 is the strongest candidate gene for lupus susceptibility in this interval, as its protein products are structurally and functionally altered. B6.Sle1c congenic mice develop Abs to chromatin by 9 mo of age with a 30% penetrance and do not develop GN. To determine whether the New Zealand White (NZW)-derived Sle1c interval would interact with New Zealand Black (NZB) genes to result in enhanced autoimmune phenotypes, NZB mice were bred with B6 or B6.Sle1c congenic mice and ∼20 female offspring were selected from each breeding for longitudinal study. These mice differ only at the Sle1c locus at which they have either a NZB/B6 or NZB/NZW genotype. NZB × B6.Sle1c mice had an accelerated onset of anti-chromatin Abs (100 vs 68% at 6 mo, p = 0.006) and anti-dsDNA Abs (45 vs 5% at 9 mo, p = 0.0048). Furthermore, median titers of anti-chromatin and anti-dsDNA Abs were significantly higher in the NZB × B6.Sle1c group compared with the NZB × B6 group. This corresponded with a higher prevalence of proliferative GN at 12 mo (55 vs 16%, p = 0.0214) as well as increased glomerular deposition of C3 (p = 0.0272) and IgG (p = 0.032), although blood urea nitrogen remained normal and significant proteinuria was not identified in either group. These data show that the Sle1c interval accelerates and augments the loss of tolerance to chromatin and dsDNA induced by NZB genes and induces significantly greater end-organ damage.

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“…It controls the proliferation of B-cells and plays roles in T-cell mediated immune regulation (Fingeroth et al, 1989). CR1 also exerts the function of cleaving various immune complexes and particles (Nicholson-Weller et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Complement Receptor 1 Expression in Peripheral Blood Mononuclear Cells and the Association with Clinicopathological Features And Prognosis of Nasopharyngeal Carcinoma

He¹,

Xi²,

Ren³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Proliferation of resting B cells is modulated by CR2 and CR1

Cited by 53 publications

References 49 publications

Complement Receptor Type 1 (CD35) Mediates Inhibitory Signals in Human B Lymphocytes

Complement Receptor Type 1 (CD35) Mediates Inhibitory Signals in Human B Lymphocytes

Augmentation of NZB Autoimmune Phenotypes by the Sle1c Murine Lupus Susceptibility Interval

Complement Receptor 1 Expression in Peripheral Blood Mononuclear Cells and the Association with Clinicopathological Features And Prognosis of Nasopharyngeal Carcinoma

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